Association between a History of herpes zoster and the risk of Sjögren’s syndrome: a nationwide, population-based, case–control study

Huang, Pei Ju; Lin, Shih‐Ping; Wu, Chun Yi; Liu, Yen-Tze; Chen, Hsin‐Hua

doi:10.1136/bmjopen-2022-061962

Cited by 3 publications

(3 citation statements)

References 48 publications

(68 reference statements)

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“…A recent nation-wide, population-based, case–control study including 5751 SS patients and 28,755 matched controls showed a significant correlation between herpes zoster exposure and SS risk, which was greater when the interval between the last visit for herpes zoster infection and the index date was <3 months (OR adjusted for comorbidities = 3.13, 95%CI = 2.20–4.45) [ 234 ].…”

Section: Autoimmune Diseasesmentioning

confidence: 99%

Herpesviridae, Neurodegenerative Disorders and Autoimmune Diseases: What Is the Relationship between Them?

De Francesco

2024

Viruses

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Alzheimer’s disease and Parkinson’s disease represent the most common forms of cognitive impairment. Multiple sclerosis is a chronic inflammatory disease of the central nervous system responsible for severe disability. An aberrant immune response is the cause of myelin destruction that covers axons in the brain, spinal cord, and optic nerves. Systemic lupus erythematosus is an autoimmune disease characterized by alteration of B cell activation, while Sjögren’s syndrome is a heterogeneous autoimmune disease characterized by altered immune responses. The etiology of all these diseases is very complex, including an interrelationship between genetic factors, principally immune associated genes, and environmental factors such as infectious agents. However, neurodegenerative and autoimmune diseases share proinflammatory signatures and a perturbation of adaptive immunity that might be influenced by herpesviruses. Therefore, they might play a critical role in the disease pathogenesis. The aim of this review was to summarize the principal findings that link herpesviruses to both neurodegenerative and autoimmune diseases; moreover, briefly underlining the potential therapeutic approach of virus vaccination and antivirals.

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Section: Autoimmune Diseasesmentioning

confidence: 99%

Herpesviridae, Neurodegenerative Disorders and Autoimmune Diseases: What Is the Relationship between Them?

De Francesco

2024

Viruses

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“…16 More recently Huang et al suggested in a nationwide population based study, an association between recently raised antimuscarinic burden and acute cardiovascular events in older adults. 17 Consequently, whilst the use of antimuscarinic medication may not be contraindicated, it is important to be aware of comorbidities and the risk of polypharmacy resulting in an unacceptable anticholinergic load, particularly in the elderly. Alternatively, avoiding antimuscarinic therapy in those patients at a higher risk of cognitive decline may offer a rationale for improving drug adherence whilst maintaining efficacy and safety.…”

Section: Anticholinergic Burden-the Long Term Effects Of Antimuscarin...mentioning

confidence: 99%

What is the best first choice oral drug therapy for OAB?

Sahai,

Robinson,

Abrams

et al. 2024

Neurourology and Urodynamics

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AimsThe management of overactive bladder (OAB) involves lifestyle changes and conservative measures in the first instance with the use of liquid/dietary advice, weight loss, and bladder training. Thereafter oral pharmacotherapy is instigated in symptomatic patients. Antimuscarinics and beta 3 agonists form the main classes of drug therapy in this field. Views on what is the best first line OAB treatment is changing based on recent evidence and adverse event profiles of these medications.MethodsAt the ICI‐RS meeting 2023, Bristol, UK this topic was discussed and debated as a proposal. The following article summarizes the concepts presented that day as well as the interactive discussion that took place thereafter.ResultsOAB guidelines are moving in many circumstances to an either antimuscarinic or beta 3 agonist approach based on patient factors. Several studies have raised concerns on the long‐term impact of antimuscarinics, in relation to cognition, dementia, cardiovascular events, and mortality all related to antimuscarinic load. Neither antimuscarinics nor beta 3 agonists have good persistence and adherence rates in the medium to long term. Several barriers also exist to prescribing including guidelines recommending utilizing drugs with the lowest acquisition cost and “step therapy.” A newer approach to managing OAB is personalized therapy in view of the many possible etiological factors and phenotypes. These concepts are highlighted in this article.ConclusionsCurrent oral pharmacotherapy in managing OAB is limited by adverse events, adherence and persistence problems. Both antimuscarinics and beta 3 agonists are efficacious but most clinical trials demonstrate significant placebo effects in this field. Personalizing treatment to the individual seems a logical approach to OAB. There is a need for better treatments and further studies are required of existing treatments with high quality longer term outcomes.

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“…Varicella is the main clinical feature after first infection with varicella zoster virus (VZV). The disease manifests as a painful vesicular rash and may present with herpes zoster (HZ) neuralgia due to occurrence of VZV from the latency of sensory root ganglia 1 . Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by excessive activation of inflammatory immune cells and accumulation of a large number of proinflammatory cytokines.…”

Section: Introductionmentioning

confidence: 99%

Exploring machine learning methods for predicting systemic lupus erythematosus with herpes

Wang

Tang

et al. 2023

Int J of Rheum Dis

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ObjectivesTo investigate whether machine learning, which is widely used in disease prediction and diagnosis based on demographic data and serological markers, can predict herpes occurrence in patients with systemic lupus erythematosus (SLE).MethodsA total of 286 SLE patients were included in this study, including 200 SLE patients without herpes and 86 SLE patients with herpes. SLE patients were randomly divided into a training group and a test group, and 18 demographic characteristics and serological indicators were compared between the two groups.ResultsWe selected basophil, monocyte, white blood cell, age, immunoglobulin E, SLE Disease Activity Index, complement 4, neutrophil, and immunoglobulin G as the basic features of modeling. A random forest model had the best performance, but logistic and decision tree analyses had better clinical decision‐making benefits. Random forest had a good consistency between feature importance judgment and feature selection. The 10‐fold cross‐validation showed the optimization of five model parameters.ConclusionThe random forest model may be an excellently performing model, which may help clinicians to identify SLE patients whose disease is complicated by herpes early.

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Association between a History of herpes zoster and the risk of Sjögren’s syndrome: a nationwide, population-based, case–control study

Cited by 3 publications

References 48 publications

Herpesviridae, Neurodegenerative Disorders and Autoimmune Diseases: What Is the Relationship between Them?

Herpesviridae, Neurodegenerative Disorders and Autoimmune Diseases: What Is the Relationship between Them?

What is the best first choice oral drug therapy for OAB?

Exploring machine learning methods for predicting systemic lupus erythematosus with herpes

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