Association between 25-hydroxyvitamin D levels and diabetes

Papadakis, Georgios; Kakava, Kassiani; Παππά, Θεοδώρα; Dogkas, Nikolaos; Villiotou, Vassiliki; Pappas, Anastasios

doi:10.1530/endoabs.41.ep419

Cited by 1 publication

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“…Many studies have indicated that patients with type 2 diabetes have a high prevalence of vitamin D deficiency. [1][2][3] In our study, the prevalence of vitamin D deficiency and insufficiency was found to be 51.8%, and the percentage of patients with an ideal level of 25(OH)D was 48.2%. The prevalence of vitamin D deficiency and insufficiency found in our study is lower than that found in other geographical areas.…”

Section: Discussionmentioning

confidence: 85%

“…The prevalence of vitamin D deficiency and insufficiency found in our study is lower than that found in other geographical areas. 1,3 This difference can be attributed to the differences in living and eating habits of people in Vietnam compared to those of other countries reported in studies. Out results are similar to others study conducted in Vietnam.…”

Section: Discussionmentioning

confidence: 96%

“…Many studies have indicated that patients with type 2 diabetes have a lower level of vitamin D and a higher prevalence of vitamin D deficiency than healthy people. [1][2][3] Results of studies on the relationship between vitamin D deficiency and type 2 diabetes include the following: In vitro studies have shown that 1.25(OH)2 D may simultaneously increase the expression of insulin receptor mRNA in U-937 human cells and the glucose uptake ability of insulin receptors. 4 Supplementation of 1.25(OH)2 D may significantly improve glucose absorption capacity of muscle cells.…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between Vitamin D Status and the Relevant Parameters of Glucose in Patients with Type 2 Diabetes

Huu¹,

Trần²,

Tran³

et al. 2021

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Introduction Clarifying the prevalence of vitamin D deficiency in diabetic patients, and the relationship between vitamin D concentration and insulin resistance, fasting plasma glucose, and HbA1C in patients in Hue City, Vietnam. Methods A cross-sectional study on 110 diabetic patients examined at Hue Central Hospital and Hue University of Medicine and Pharmacy Hospital. These patients were collected venous blood sampling, and the 25(OH)D test, fasting plasma glucose test, fasting insulin test, HOMA-IR and QUICKI calculation. Results Vitamin D deficiency and insufficiency prevalence were 51.8%. The average concentration of 25(OH)D (ng/mL) was 30.67 ± 8.55; this concentration in fasting glucose level ≤8 mmol/l group and >8 mmol/l group was 32.08 ± 9.26 and 28.55±6.91 (p = 0.033); it was 32.95 ± 8.58 and 28.97 ± 8.17 in HOMA-IR ≤3.5 and HOMA-IR >3.5 group, (p = 0.015); in QUICKI ≤0.32 group, it was 29.16 ± 8.12; in QUICKI >0.32 group, it was 32.85 ± 8.76 (p = 0.025). Patients with an ideal exercise level have higher average levels of 25(OH)D (32.11±8.62 vs 26.83±7.16, p=0.003). The average levels of 25(OH)D in male patients are higher than in female patients (33.47±0.08 vs 29.01±8.43, p=0.008). Vitamin D deficiency and insufficiency prevalence in patients with HOMA-IR ≤3.5 and QUICKI >0.32 were 36.2% and 37.8%, whereas in those with HOMA-IR >3.5 and QUICKI ≤0.32 they were 63.5% and 61.5% (p = 0.007 and 0.02, respectively). 25(OH)D is negative correlation with fasting glucose level and HOMA-IR, with r = −0.229 and −0.192, respectively (p = 0.016 and 0.045); 25(OH)D was positively correlated with QUICKI, with r = 0.235, p = 0.008. Conclusion Patients who have better glucose-related parameters, such as fasting blood sugar, HOMA-IR and QUICKI, have a better vitamin D status. Some blood sugar-related factors, such as exercise level and sex, are related to vitamin D status.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 96%