Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men

Lee, D. M; Tajar, Abdelouahid; Ulubaev, Aslan; Pendleton, Neil; O'Neill, Terence W; O’Connor, Daryl B.; Bártfai, György; Boonen, Steven; Bouillon, Roger; Casanueva, Felipe F.; Finn, Joseph D.; Forti, Gianni; Giwercman, Aleksander; Han, Tae-Kyung; Huhtaniemi, Ilpo; Kula, Krzysztof; Lean, Michael E. J.; Punab, Margus; Silman, Alan J.; Vanderschueren, Dirk; Wu, Fenghui

doi:10.1136/jnnp.2008.165720

Cited by 139 publications

(101 citation statements)

References 42 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Eight cross-sectional and case-control studies, which included data from 2749 participants, contributed to this analysis. Taken together, these studies showed a higher average MMSE score in participants with higher VD concentrations [7,31,32]. The role of VD in skeletal health is well established, but more recent findings have also linked VD deficiency to a range of non-skeletal conditions such as cardiovascular disease, cancer, stroke and metabolic disorders including diabetes.…”

Section: Discussionmentioning

confidence: 73%

Low Vitamin D Serum Levels May Be a Modifiable Risk Factor for Obesity and Cognitive Impairment in Middle-Age Egyptian Women

2014

Maced J Med Sci

View full text Add to dashboard Cite

SUBJECTS AND METHODS:This study included 2 groups, Group-1(cases) consists of 120 obese females and Group-2 (controls) consists of 30 non-obese females. The included females were subjected to full clinical examination, anthropometric measurements and Kendrick Battery for evaluation of cognitive functions (short term memory and attention). Evaluation of serum Vitamin D, Parathyroid hormone, C-peptide and fasting blood glucose were done. The obese group was put on a balanced low caloric diet (900-1000 K Calories/day) for 2 months, where reevaluation was performed. RESULTS:Comparing obese group with non-obese control group revealed significant lower mean level of serum vitamin D associated with significant lower cognitive functions test and higher fasting blood glucose. After 2 months of low caloric diet, a significant increase in the serum level of vitamin D, accompanied with improvement in cognitive functions and decrease in fasting blood glucose and improved insulin resistance was seen. A correlation is found between vitamin D serum level and cognitive functions.CONCLUSION: A lower vitamin D serum level could be a modifiable risk factor for obesity, insulin resistance and cognitive impairment in middle age females.

show abstract

Section: Discussionmentioning

confidence: 73%

Low Vitamin D Serum Levels May Be a Modifiable Risk Factor for Obesity and Cognitive Impairment in Middle-Age Egyptian Women

2014

Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…A study using the data of the National Health and Nutrition Examination Survey (NHANES) conducted from 2005 to 2006 found no relationship between the vitamin D level and depression [6]. However, a study of 3,369 people aged 40~79 in Europe conducted in 2009 and a prospective cohort study in the United States conducted in 2010 reported that the lower the level of vitamin D was, the higher the level of depression was [7,8]. In Korea, the relationship between vitamin D and depression was analyzed by the data of the Korean National Health and Nutrition Examination Survey (KNHANES) conducted from 2008 to 2010, and no association was found [9].…”

Section: The Need For Researchmentioning

confidence: 99%

The Effect of Vitamin D and Calcium on Cognitive Function and Depression in the Elderly Living in a City

Lee

Kim²

2017

J Korean Acad Community Health Nurs

View full text Add to dashboard Cite

Purpose: This study aims to examine the influence of vitamin D and calcium on depression and cognitive function of the elderly living alone in a city. Methods: The participants were registered in eight senior centers in S city and they had lived alone. Data were collected between November 28, 2014 and March 7, 2015. A total of 155 people participated in data collection to measure the serum vitamin D, the serum calcium, depression, and cognitive function. The data were analyzed with t-test, ANOVA, Pearson's correlation and multiple regression analysis. Results: There were significant differences in depression according to gender and perceptions of health status. Depression correlated significantly with the serum calcium and perceptions of health status, and a stepwise regression analysis showed that the perceptions of health status were significant. There were significant differences in cognitive function according to education level and age. Cognitive function correlated significantly with the serum vitamin D and a stepwise regression analysis showed that education level and age were significant. Conclusion: Consequently, elderly people with poor perceptions of their health status need a depressive intervention program and those with a higher age and lower level of education need a cognitive function intervention program.

show abstract

“…Özellikle ileri yaşlarda düşük vitamin D seviyelerinin, demansla ilişkisi oldukça yüksek olan hafıza ve yönetici fonksiyonlarda gerilemeye neden olduğu gösterilmiştir (10)(11)(12). Ancak bu bilginin daha erken yaşlarda doğruluğu ile ilgili veriler yetersizdir (2,13,14). Bu nedenle, vitamin D düzeyi düşük olan erişkin kadınlarda bilişsel fonksiyonları değerlendirmeyi ve vitamin D düzeyi ile bilişsel fonksiyonlar arasında ilişki olup olmadığını araştırmayı amaçladık.…”

Section: Introductionunclassified

Vitamin D Düzeyi Düşük Erişkin Kadınlarda Bilişsel Fonksiyonların Standardize Mini Mental Test ve Montreal Bilişsel Değerlendirme Ölçeği ile Değerlendirilmesi

Can¹,

Çelik²,

Can³

et al. 2017

Tod

View full text Add to dashboard Cite

Objective: The aim of the study was to evaluate cognitive functioning in adult women with low level vitamin D and to investigate the relationship between vitamin D and cognitive functioning. Materials and Methods: Seventy-one women patients aged 18-50 with 25-OH vitamin D 3 level <30 ng/mL referred to outpatient clinic were enrolled in the study. 25-OH vitamin D 3 level, calcium, phosphate, alkaline phosphatase, parathyroid hormone (PTH) blood levels were studied in all the patients. Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MOCA) were used to assess cognitive functioning. The patients were divided into 2 groups according to vitamin D levels: <10 ng/mL (group 1, n=34) and between 11-29 ng/mL (group 2, n=37). Results: There was no significant difference between the group 1 and 2 for demographic and clinical characteristics except for vitamin D and PTH (p>0.05). Patients in group 1 had their vitamin D levels significantly lower and PTH levels higher than group 2 (p<0.05). There was no significant difference in MOCA and MMSE scores between the groups (p>0.05). Although there was a relationship between education and MOCA and MMSE scores, we didn't find any significant relationship between age and vitamin D levels and MOCA and MMSE scores. Conclusion: Although approximately 50% of adult women whose vitamin D levels were low had reduced cognitive function, there was no relationship between vitamin D levels and cognitive functions.

show abstract

Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men

Abstract: In this study, lower 25(OH)D levels were associated with poorer performance on the DSST. Further research is warranted to determine whether vitamin D sufficiency might have a role in preserving cognitive function in older adults.

Cited by 139 publications

References 42 publications

Low Vitamin D Serum Levels May Be a Modifiable Risk Factor for Obesity and Cognitive Impairment in Middle-Age Egyptian Women

Low Vitamin D Serum Levels May Be a Modifiable Risk Factor for Obesity and Cognitive Impairment in Middle-Age Egyptian Women

The Effect of Vitamin D and Calcium on Cognitive Function and Depression in the Elderly Living in a City

Vitamin D Düzeyi Düşük Erişkin Kadınlarda Bilişsel Fonksiyonların Standardize Mini Mental Test ve Montreal Bilişsel Değerlendirme Ölçeği ile Değerlendirilmesi

Contact Info

Product

Resources

About