Association and predictive value of soluble thrombomodulin with mortality in patients with acute respiratory distress syndrome: systematic review and meta-analysis

Liu, Zhenjun; Li, Yang; Zhao, Qian; Kang, Yan

doi:10.21037/atm-23-432

Cited by 1 publication

(1 citation statement)

References 33 publications

(39 reference statements)

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“…Evidence from a study on rats with septic peritonitis suggests that recombinant human thrombomodulin (rhTM) can reduce mortality and lessen the severity of ALI, likely due to its anti-inflammatory and anticoagulant properties [79]. A systematic review and metaanalysis, involving a total of 13 studies, was conducted to assess the association and predictive value of soluble thrombomodulin (sTM) levels for mortality in ARDS patients; the results showed that elevated sTM levels were linked to a higher mortality risk [80]. The results of another study that included children with acute respiratory failure who were receiving mechanical ventilation showed that higher thrombomodulin levels were linked to higher mortality and organ dysfunction [81].…”

Section: Thrombomodulinmentioning

confidence: 99%

Advances in Biomarkers for Diagnosis and Treatment of ARDS

Ge,

Wang,

Peng

2023

Diagnostics

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Acute respiratory distress syndrome (ARDS) is a common and fatal disease, characterized by lung inflammation, edema, poor oxygenation, and the need for mechanical ventilation, or even extracorporeal membrane oxygenation if the patient is unresponsive to routine treatment. In this review, we aim to explore advances in biomarkers for the diagnosis and treatment of ARDS. In viewing the distinct characteristics of each biomarker, we classified the biomarkers into the following six categories: inflammatory, alveolar epithelial injury, endothelial injury, coagulation/fibrinolysis, extracellular matrix turnover, and oxidative stress biomarkers. In addition, we discussed the potential role of machine learning in identifying and utilizing these biomarkers and reviewed its clinical application. Despite the tremendous progress in biomarker research, there remain nonnegligible gaps between biomarker discovery and clinical utility. The challenges and future directions in ARDS research concern investigators as well as clinicians, underscoring the essentiality of continued investigation to improve diagnosis and treatment.

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Section: Thrombomodulinmentioning

confidence: 99%