2007
DOI: 10.1007/s00774-007-0769-5
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Association analysis of the polymorphisms of the VDR gene with bone mineral density and the occurrence of fractures

Abstract: Associations of the FokI, BsmI, ApaI, and TaqI polymorphisms of the vitamin D receptor (VDR) gene with the bone mineral density (BMD) of the lumbar part of the spinal column (BMD LS) and the neck of the femur (BMD FN), and with the occurrence of fractures, were studied using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis on DNA isolated from peripheral blood of 239 women and 40 men from the region of western Poland. Three polymorphisms of the 3' end of the VDR … Show more

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Cited by 28 publications
(18 citation statements)
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“…Among these studies, 21 studies concerned the association of the Fok1 polymorphism with osteoporosis [9,72-91], while 26 studies investigated the association between Bsm1polymorphism and osteoporosis risk [92-117]. Also 14 articles evaluated both polymorphism associations with osteoporosis [118-131]. All of these 61 studies provided sufficient data to calculate the possible relationship between the two polymorphisms of the VDR gene and osteoporosis risk.…”
Section: Resultsmentioning
confidence: 99%
“…Among these studies, 21 studies concerned the association of the Fok1 polymorphism with osteoporosis [9,72-91], while 26 studies investigated the association between Bsm1polymorphism and osteoporosis risk [92-117]. Also 14 articles evaluated both polymorphism associations with osteoporosis [118-131]. All of these 61 studies provided sufficient data to calculate the possible relationship between the two polymorphisms of the VDR gene and osteoporosis risk.…”
Section: Resultsmentioning
confidence: 99%
“…Among a group of prepubertal American girls of Mexican descent, Sainz et al [158] found that girls with the aa and bb genotypes had 2 to 3% higher femoral bone density and an 8 to 10% higher vertebral bone density than girls with AA and BB genotypes. Horst-Sikorska et al [159] also observed a statistically significant association of the VDR gene polymorphisms and haplotypes with the BMD and with the occurrence of fractures. However, several other studies found no association between VDR genotype and BMD [160; 161].…”
Section: Genes Containing Known Bmd-associated Polymorphismsmentioning
confidence: 97%
“…Large-scale studies, functional studies and studies of other VDR polymorphisms are necessary to understand the interaction of VDR and other ocular pathway proteins in the development of myopia. [34]…”
Section: Resultsmentioning
confidence: 99%