Association analysis of the HLA-C gene in Japanese alopecia areata

Haida, Yuko; Ikeda, Shigaku; Takagi, Atsushi; Komiyama, Etsuko; Mabuchi, Tomotaka; Ozawa, A.; Kulski, Jerzy K.; Inoko, Hidetoshi; Oka, Akira

doi:10.1007/s00251-013-0703-z

Cited by 22 publications

(17 citation statements)

References 38 publications

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“…Of great significance for understanding AA susceptibility, subtle changes to MHC structure, encoded by specific gene alleles, can determine increased or reduced presentation of specific antigen epitopes 102 . Consequently, specific alleles for MHC class II, and to a lesser extent MHC class I, can be strongly correlated to various autoimmune diseases, and AA is no exception 35,91,103‐106 . While conflicting evidence has been published on the HLA associations of AA in different populations, large‐scale genome wide association studies implicate HLA‐DR as a key aetiological driver of AA, 103 consistent with an important supporting role for MHC class II mediated antigen presentation to CD4 + T cells.…”

Section: Mechanisms Of Hf Ipmentioning

confidence: 99%

“…While conflicting evidence has been published on the HLA associations of AA in different populations, large‐scale genome wide association studies implicate HLA‐DR as a key aetiological driver of AA, 103 consistent with an important supporting role for MHC class II mediated antigen presentation to CD4 + T cells. Polymorphisms in HLA‐A, 104 HLA‐B (along with MICA) 107 and HLA‐C 105 are also linked to AA risk.…”

Section: Mechanisms Of Hf Ipmentioning

confidence: 99%

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Hair follicle immune privilege and its collapse in alopecia areata

Bertolini

McElwee

Gilhar

et al. 2020

Experimental Dermatology

174

157

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Anagen stage hair follicles (HFs) exhibit “immune privilege (IP)” from the level of the bulge downwards to the bulb. Both passive and active IP mechanisms protect HFs from physiologically undesired immune responses and limit immune surveillance. IP is relative, not absolute, and is primarily based on absent, or greatly reduced, intra‐follicular antigen presentation via MHC class I and II molecules, along with prominent expression of “no danger” signals like CD200 and the creation of an immunoinhibitory signalling milieu generated by the secretory activities of HFs. Perifollicular mast cells, Tregs and other immunocytes may also contribute to HF IP maintenance in healthy human skin. Collapse of anagen hair bulb IP is an essential prerequisite for the development of alopecia areata (AA). In AA, lesional HFs are rapidly infiltrated by NKG2D + T cells and natural killer (NK) cells, while perifollicular mast cells acquire a profoundly pro‐inflammatory phenotype and interact with autoreactive CD8+ T cells. Using animal models, significant functional evidence has accumulated that demonstrates the dominance of the immune system in AA pathogenesis. Purified CD8+T‐cell and NK cell populations alone, which secrete fγ, suffice to induce the AA phenotype, while CD4+T‐cells aggravate it, and Tregs and iNKT cells may provide relative protection against AA development. While IP collapse may be induced by exogenous agents, inherent IP deficiencies might confer increased susceptibility to AA for some individuals. Thus, a key goal for effective AA management is the re‐establishment of a functional HF IP, which will also provide superior protection from disease relapse.

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Section: Mechanisms Of Hf Ipmentioning

confidence: 99%

Section: Mechanisms Of Hf Ipmentioning

confidence: 99%

Hair follicle immune privilege and its collapse in alopecia areata

Bertolini

McElwee

Gilhar

et al. 2020

Experimental Dermatology

174

157

View full text Add to dashboard Cite

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“…18 The significant association of alleles HLA-DQB1*03, HLA-B-18, and HLA-A2 and AA was demonstrated in several different populations. 19,20 Microchimerism might clarify this condition.…”

Section: Discussionmentioning

confidence: 97%

“…A number of studies investigated whether the HLA class alleles of the fetus and mother were related to the occurrence of autoimmune disease . The significant association of alleles HLA‐DQB1*03, HLA‐B‐18, and HLA‐A2 and AA was demonstrated in several different populations . Microchimerism might clarify this condition.…”

Section: Discussionmentioning

confidence: 99%

Microchimerism in alopecia areata

Terzi¹,

Bulut

Türsen

et al. 2015

Int J Dermatology

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“…Recently, in a Japanese population of 157 individuals with AA, a strong association with C*04:01 and C*15:02 was described. 15 The variability concerning class I and class II gene specificities in AA patients of different countries could be attributed to the populations' various genetic predispositions, as well as the influence of different behaviors, environmental and ethnic factors. 10 …”

Section: Discussionmentioning

confidence: 99%

Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population

Barbosa

Prestes-Carneiro

Sobral

et al. 2016

An. Bras. Dermatol.

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BackgroundAlopecia areata (AA) is a common disorder of unknown etiology that affects approximately 0.7% to 3.8% of patients among the general population. Currently, genetic and autoimmune factors are emphasized as etiopathogenic. Studies linking Human Leukocyte Antigens (HLA) to AA have suggested that immunogenetic factors may play a role in the disease's onset/development.ObjectivesTo investigate an association between AA and HLA class I/II in white Brazilians. Methods: Patients and control groups comprised 33 and 112 individuals, respectively. DNA extraction was performed by column method with BioPur kit. Allele's classification was undertaken using the PCR-SSO technique. HLA frequencies were obtained through direct counting and subjected to comparison by means of the chi-square test.ResultsMost patients were aged over 16, with no familial history, and developed partial AA, with no recurrent episodes. Patients showed a higher frequency of HLA-B*40, HLA-B*45, HLA-B*53 and HLA-C*04 compared with controls, although P was not significant after Bonferroni correction. Regarding HLA class II, only HLA-DRB1*07 revealed statistical significance; nevertheless, it featured more prominently in controls than patients (P=0.04; Pc=0.52; OR=0.29; 95%; CI=0.07 to 1.25). P was not significant after Bonferroni correction.ConclusionsThe development of AA does not seem to be associated with HLA in white Brazilians, nor with susceptibility or resistance. The studies were carried out in populations with little or no miscegenation, unlike the Brazilian population in general, which could explain the inconsistency found.

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Association analysis of the HLA-C gene in Japanese alopecia areata

Cited by 22 publications

References 38 publications

Hair follicle immune privilege and its collapse in alopecia areata

Hair follicle immune privilege and its collapse in alopecia areata

Microchimerism in alopecia areata

Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population

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