Association analysis of the constructed linkage maps covering TLR2 and TLR4 with clinical mastitis in Norwegian Red cattle

Opsal, M.A.; Lien, Sigbjørn; Brenna-Hansen, S.; Olsen, Harald; Våge, Dag Inge

doi:10.1111/j.1439-0388.2007.00704.x

Cited by 16 publications

(8 citation statements)

References 20 publications

(23 reference statements)

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“…One gene complex which has been long recognised as being associated with mastitis susceptibility or resistance is the Major Histocompatibility Complex, where Class I [156] were found to be associated with health traits including measurements of somatic cell counts [161] and Class II [139] genes have been demonstrated as playing an important role in presenting antigen to cells of the immune system and in response of lymphocytes to mastitis pathogens [123]. More recently, other genes and gene complexes have been shown to play a role in the pathogenesis of mastitis, including Toll-like receptors [121]. …”

Section: Trends At Host Levelmentioning

confidence: 99%

Changing trends in mastitis

Zadoks

Fitzpatrick

2009

Ir Vet J

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The global dairy industry, the predominant pathogens causing mastitis, our understanding of mastitis pathogens and the host response to intramammary infection are changing rapidly. This paper aims to discuss changes in each of these aspects. Globalisation, energy demands, human population growth and climate change all affect the dairy industry. In many western countries, control programs for contagious mastitis have been in place for decades, resulting in a decrease in occurrence of Streptococcus agalactiae and Staphylococcus aureus mastitis and an increase in the relative impact of Streptococcus uberis and Escherichia coli mastitis. In some countries, Klebsiella spp. or Streptococcus dysgalactiae are appearing as important causes of mastitis. Differences between countries in legislation, veterinary and laboratory services and farmers' management practices affect the distribution and impact of mastitis pathogens. For pathogens that have traditionally been categorised as contagious, strain adaptation to human and bovine hosts has been recognised. For pathogens that are often categorised as environmental, strains causing transient and chronic infections are distinguished. The genetic basis underlying host adaptation and mechanisms of infection is being unravelled. Genomic information on pathogens and their hosts and improved knowledge of the host's innate and acquired immune responses to intramammary infections provide opportunities to expand our understanding of bovine mastitis. These developments will undoubtedly contribute to novel approaches to mastitis diagnostics and control.

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Section: Trends At Host Levelmentioning

confidence: 99%

Changing trends in mastitis

Zadoks

Fitzpatrick

2009

Ir Vet J

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“…Bovine TLR4 is highly polymorphic with more than 40 SNPs (single nucleotide polymorphisms) of the bovine TLR4 gene have been found to date, which means an average of 1 SNP per 90 bp (Wang et al, 2007). TLR4 gene discovered across 14 breeds of cattle (Sharma et al, 2006;Wang et al, 2007;Opsal et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

The influence of TLR4 gene polymorphisms on milk quality and composition of Lithuanian Holstein cows

et al. 2020

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This study investigated bovine TRL4 gene c.9421C>T, c.2021C>T and c.-10C>T polymorphisms and their relationship with somatic cell count and indicators of milk composition. Blood samples were collected from 152 Lithuanian Holstein dairy cows. The method of polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) was used to genotype TLR4 gene polymorphisms. The data concerning somatic cell count and milk composition indicators (fat, protein, lactose) were analysed. The influence of genes and statistical significance of differences between different genotypes was evaluated by the one-factor dispersion analysis (ANOVA). Results showed that c.9421C>T was significantly associated with somatic cell count in milk. Also a significant association between the genotypes of c.9421C>T and somatic cell count was found (P<0.05). Cattle with the TT genotype showed the lowest somatic cell count. TLR4 gene polymorphisms c.2021C>T and c.-10C>T have no significant effect on mastitis resistance and milk composition. Analysis of the combined genotypes TC/CC of c.2021C>T and c.9421C>T allowed us to determine the possible association of SNPs with the somatic cell count and lactose content. The study showed a significant association between the somatic cell count (SCC) and TLR4 polymorphism c.9421C>T in Lithuanian Holstein cows. SCS of cows with a TT genotype was significantly lower and indicated the association of TT genotype with resistance to mastitis in c.9421C>T and allele T might be the beneficial allele for mastitis resistance.

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“…Portanto, a variação genética da expressão desses fatores pode influenciar a suscetibilidade à mastite (OPSAL et al, 2008).…”

Section: Barreiras Celularesunclassified