Association analysis of <i>IGF2</i> gene polymorphisms with growth traits of Dezhou donkey

Chang, Tingjin; Li, Mei; An, Xiaoya; Bai, Fuxia; Wang, Fuwen; Li, Jingling; Lei, Chuzhao; Dang, Ruihua

doi:10.1080/10495398.2021.2013860

Cited by 5 publications

(5 citation statements)

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“…Guo et al [ 28 ] identified a novel transcript of the bovine SPEF2 gene, which may be caused by the SNP g.11043 C > T located in intron 1, and altered the splicing factor binding protein SC35 binding to the target sequence; SNP g.11043 C > T was found to be significantly associated with sperm malformation rate. Chang et al [ 6 ] found that SNPs (g.291322 C > T and g.281766 G > A ) located in the IGF2 intron region were significantly associated with rump height and body length in female Dezhou donkeys ( p < 0.05). Therefore, SNPs located in introns can also be potential molecular markers for donkey breeding.…”

Section: Resultsmentioning

confidence: 99%

“…Body size is a complex trait regulated by various genes and signal pathways. IGF1 [ 5 ], IGF2 [ 6 ], ACSL1 [ 7 ], ACSL3 [ 8 ], CDKL5 [ 9 ] and TBX3 [ 10 ] have been proven to be associated with the body size traits of Dezhou donkeys. For example, the TBX3 gene was found to be significantly associated with body height, body length and chest circumference in donkeys [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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A Novel A > G Polymorphism in the Intron 1 of LCORL Gene Is Significantly Associated with Hide Weight and Body Size in Dezhou Donkey

Wang

Shi

Liu

et al. 2022

Animals

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Several studies have shown the association between the ligand-dependent nuclear receptor compression-like protein (LCORL) gene and body size in horses, pigs and donkeys. Based on previous studies, the LCORL gene was hypothesized to be associated with growth traits and hide weight in Dezhou donkeys. In this study, we aimed to reveal the variation of the LCORL gene in the Dezhou donkey and explore whether the gene is associated with hide weight and body size. In this study, genetic polymorphisms in the LCORL gene of the Dezhou donkey were studied using targeted sequencing technology, and single nucleotide polymorphisms (SNPs) of the LCORL gene were analyzed for association with hide weight and body size in Dezhou donkeys. The results showed that there was an SNP locus situated in intron 1 of the LCORL gene. Association analysis revealed that individuals with the GG genotype had significantly higher body height, body length, chest circumference and hide weight than those with the AA genotype (p < 0.05). Therefore, the g.112558859 A > G locus can be used as a potential candidate marker affecting body size and hide weight. This study provides the foundation for breeding high-quality donkeys with high hide yield.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Novel A > G Polymorphism in the Intron 1 of LCORL Gene Is Significantly Associated with Hide Weight and Body Size in Dezhou Donkey

Wang

Shi

Liu

et al. 2022

Animals

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“…Furthermore, they found two SNPs (g.281766G>A and g.291322C>T) in the IGF2 gene that were significantly correlated with body length and rump height in female Dezhou donkeys. Chang et al [80] found that the expression of the IGF2 gene was higher in various tissues of juvenile donkeys than in adult donkeys, which showed their strong correlation in the growth and development of female Dezhou donkeys. Similarly, another study [81] found three single-nucleotide polymorphisms (SNPs) that were identified in the IGF1 gene of Dezhou donkeys, and the SNP (c.413G>A) was significantly associated with body weight, height, chest circumference, and cannon circumference, which are the best indicators of meat quantity and quality.…”

Section: Genetic Markers Associated With Growth and Meat Production P...mentioning

confidence: 99%

“…Noteworthy research [78,79] underscores the significant associations between the ACSL3 and ACSL1 genes and growth traits, firmly establishing them as influential factors in optimizing meat production performance, a vital aspect of livestock management. In alignment with this theme, another study focused on discerning the relationship between single-nucleotide polymorphisms (SNPs) within the IGF2 gene and body size traits in Chinese Dezhou donkeys [80]. Furthermore, they found two SNPs (g.281766G>A and g.291322C>T) in the IGF2 gene that were significantly correlated with body length and rump height in female Dezhou donkeys.…”

Section: Genetic Markers Associated With Growth and Meat Production P...mentioning

confidence: 99%

Exploring Genetic Markers: Mitochondrial DNA and Genomic Screening for Biodiversity and Production Traits in Donkeys

Huang,

Khan,

Chai

et al. 2023

Animals

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Donkeys (Equus asinus) play a pivotal role as essential livestock in arid and semi-arid regions, serving various purposes such as transportation, agriculture, and milk production. Despite their significance, donkey breeding has often been overlooked in comparison to other livestock species, resulting in limited genetic improvement programs. Preserving donkey genetic resources within each country necessitates the establishment of breed conservation programs, focusing on managing genetic diversity among populations. In recent years, significant strides have been made in sequencing and analyzing complete mitochondrial DNA (mtDNA) molecules in donkeys. Notably, numerous studies have honed in on the mitochondrial D-loop region, renowned for its remarkable variability and higher substitution rate within the mtDNA genome, rendering it an effective genetic marker for assessing genetic diversity in donkeys. Furthermore, genetic markers at the RNA/DNA level have emerged as indispensable tools for enhancing production and reproduction traits in donkeys. Traditional animal breeding approaches based solely on phenotypic traits, such as milk yields, weight, and height, are influenced by both genetic and environmental factors. To overcome these challenges, genetic markers, such as polymorphisms, InDel, or entire gene sequences associated with desirable traits in animals, have achieved widespread usage in animal breeding practices. These markers have proven increasingly valuable for facilitating the selection of productive and reproductive traits in donkeys. This comprehensive review examines the cutting-edge research on mitochondrial DNA as a tool for assessing donkey biodiversity. Additionally, it highlights the role of genetic markers at the DNA/RNA level, enabling the informed selection of optimal production and reproductive traits in donkeys, thereby driving advancements in donkey genetic conservation and breeding programs.

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“…The IGF-2 is expressed in many tissues, in particular the placenta (Forbes et al, 2020 ). The IGF-2 plays an important role in follicular growth and in oocyte and embryonic development (Sirotkin et al, 2000 ; Chang et al, 2021 ), generally considered as a major growth factor involved in the early body development (Chang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Liver fat metabolism of broilers regulated by Bacillus amyloliquefaciens TL via stimulating IGF-1 secretion and regulating the IGF signaling pathway

Chen

Zhou

et al. 2022

Front. Microbiol.

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Bacillus amyloliquefaciens TL (B.A-TL) is well-known for its capability of promoting protein synthesis and lipid metabolism, in particular, the abdominal fat deposition in broilers. However, the underlying molecular mechanism remains unclear. In our study, the regulations of lipid metabolism of broilers by B.A-TL were explored both in vivo and in vitro. The metabolites of B.A-TL were used to simulate in vitro the effect of B.A-TL on liver metabolism based on the chicken hepatocellular carcinoma cell line (i.e., LMH cells). The effects of B.A-TL on lipid metabolism by regulating insulin/IGF signaling pathways were investigated by applying the signal pathway inhibitors in vitro. The results showed that the B.A-TL metabolites enhanced hepatic lipid synthesis and stimulated the secretion of IGF-1. The liver transcriptome analysis revealed the significantly upregulated expressions of four genes (SI, AMY2A, PCK1, and FASN) in the B.A-TL treatment group, mainly involved in carbohydrate digestion and absorption as well as biomacromolecule metabolism, with a particularly prominent effect on fatty acid synthase (FASN). Results of cellular assays showed that B.A-TL metabolites were involved in the insulin/IGF signaling pathway, regulating the expressions of lipid metabolism genes (e.g., FASN, ACCα, LPIN, and ACOX) and the FASN protein, ultimately regulating the lipid metabolism via the IGF/PI3K/FASN pathway in broilers.

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Association analysis of IGF2 gene polymorphisms with growth traits of Dezhou donkey

Cited by 5 publications

References 36 publications

A Novel A > G Polymorphism in the Intron 1 of LCORL Gene Is Significantly Associated with Hide Weight and Body Size in Dezhou Donkey

A Novel A > G Polymorphism in the Intron 1 of LCORL Gene Is Significantly Associated with Hide Weight and Body Size in Dezhou Donkey

Exploring Genetic Markers: Mitochondrial DNA and Genomic Screening for Biodiversity and Production Traits in Donkeys

Liver fat metabolism of broilers regulated by Bacillus amyloliquefaciens TL via stimulating IGF-1 secretion and regulating the IGF signaling pathway

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