Association analysis of GSTT1, GSTM1 genotype polymorphisms and serum total GST activity with ischemic stroke risk

Türkanoğlu, Aysun; Demirdöğen, Birsen Can; Demirkaya, Şeref; Bek, Semai; Adalı, Orhan

doi:10.1007/s10072-010-0330-5

Cited by 34 publications

(18 citation statements)

References 39 publications

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“…Stroke patients who present lower GST activity might be a susceptibility factor for oxidative stress injury [13] [14,15,16]. In Caucasians GSTT1 and GSTM1 null genotype incidence are 13-26 and 42-60 %, respectively [17,18]. Our results are in concordance with previous studies.…”

Section: Discussionsupporting

confidence: 95%

“…Polonikov et al [20] showed that no differences were observed with GSTM1 and GSTP1 gene polymorphisms and a significant difference was observed in GSTT1 null genotypes (OR 1.51, 95 % CI 1.09-2.07, p \ 0.001). However, Polonikov et al's data were inconsistent with the results of a recent association study, which did not find any significant associations between the GSTM1 and GSTT1 null genotypes and ischemic cerebrovascular disease in a large cohort of Danish patients [21] and other studies [11,13,17,19,22]. Shyu et al investigated the association between DNA gene-repair gene polymorphism and LAA stroke risk.…”

Section: Discussionmentioning

confidence: 94%

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The impact of detoxifying and repair gene polymorphisms on oxidative stress in ischemic stroke

et al. 2016

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Stroke is a multifactorial disease caused by the combination of certain risk factors and genetic factors. There are possible risk factors having important role in the pathogenesis of stroke. The most important environmental factors are cigarette smoking and oxidative stress which have different sources. GST (M1, T1, P1) have major roles in detoxification of the products of oxidative stress and they are polymorphic. DNA damages can also be repaired by repair enzymes such as OGG1 and XRCC1 which are highly polymorphic and have pivotal roles in repair systems. In the present study, we investigated that polymorphisms in genes involved in detoxification and DNA-repair pathways might modify the individual's risk for ischemic stroke. Furthermore, the products of oxidative stress and antioxidant capacity were measured and the impact of gene polymorphism on them was evaluated. Our data showed that OGG1 Ser326Cys and XRCC1 Arg399Gln gene polymorphisms had impacts on the development of stroke.

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Section: Discussionsupporting

confidence: 95%

Section: Discussionmentioning

confidence: 94%

The impact of detoxifying and repair gene polymorphisms on oxidative stress in ischemic stroke

et al. 2016

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“…(catalyzing the conversion of H 2 O 2 to water and oxygen), while GST catalyzes a variety of reactions that detoxify endogenous compounds, including peroxidized lipids (Das and Bishayi 2010;Turkanoglu et al 2010). We found that both CAT activity and cat expression decreased with oxygen depletion.…”

Section: Discussionmentioning

confidence: 79%

Expressions of oxidative stress-related genes and antioxidant enzyme activities in Mytilus galloprovincialis (Bivalvia, Mollusca) exposed to hypoxia

et al. 2013

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Background: In this study, we investigated transcription and enzyme level responses of mussels Mytilus galloprovincialis exposed to hypoxic conditions. Genes for catalase (CAT), cytochrome P450, glutathione Stransferase (GST), metallothionein, superoxide dismutase (SOD), cytochrome c oxidase subunit 1 (COX-1), and NADH dehydrogenase subunit 2 were selected for study. Transcriptional changes were investigated in mussels exposed to hypoxia for 24 and 48 h and were compared to changes in control mussels maintained at normal oxygen levels. Activities of CAT, GST, and SOD enzymes, and lipid peroxidation (LPO) were also investigated in mussels following exposure to hypoxia for 24, 48, and 72 h. Results: Relative to the control group, the CAT activity decreased in all hypoxia treatments, while the activity of GST significantly increased in mussels exposed to hypoxia for 24 and 48 h, but decreased in those exposed for 72 h. The LPO levels were significantly higher in mussels in the 24-and 48-h hypoxia treatments than those in the control mussels, but there was no significant change in the SOD activities among all hypoxia treatments. Messenger RNA levels for the CAT, cytochrome P450, GST, metallothionein, and SOD genes were not significantly affected by hypoxic conditions for 48 h, but the expressions of the COX-1 and NADH dehydrogenase subunit 2 genes were significantly repressed in mussels in both the 24-and 48-h exposure treatments.

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“…In contrast, the case group was composed of Caucasian individuals who had suffered from ischemic stroke in the study by Türkanoğlu et al (2010), who found an overall lower prevalence of the GSTM1 present genotype (49.4% (N = 172) and 43.8% (N = 105) for the case and control groups, respectively). In addition, there was no significant differences between case and control groups.…”

Section: Discussionmentioning

confidence: 89%

GSTM1 polymorphism in patients with clinical manifestations of atherosclerosis

et al. 2017

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ABSTRACT. Atherosclerosis is characterized by lesions, called atheroma or atheromatous plaques, in the inner layer of blood vessels, which block the vascular lumen and weaken the underlying tunica media. Several modifiable and non-modifiable risk factors for the development of atherosclerosis exist. The modifiable risk factors include hypertension, smoking, obesity, high LDL and low HDL cholesterol levels, sedentary lifestyle, and stress; the non-modifiable factors include diabetes mellitus, family history of hypertension and heart disease, thrombophilia, sex, age, and genetic factors. The association of polymorphisms in GST with coronary artery disease has been studied since the polymorphisms can affect enzyme activity and contribute to the onset of atherosclerosis. We analyzed polymorphisms in GSTM1 in individuals diagnosed with atherosclerosis as well as in healthy individuals (control group). The frequency of the GSTM1 present genotype in the atherosclerosis group was 1.2 times higher than that observed in the control group. We found no sex-or alcoholconsumption-dependent differences between the occurrences of the present and null genotypes. However, the GSTM1 present genotype occurred in 52

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Association analysis of GSTT1, GSTM1 genotype polymorphisms and serum total GST activity with ischemic stroke risk

Cited by 34 publications

References 39 publications

The impact of detoxifying and repair gene polymorphisms on oxidative stress in ischemic stroke

The impact of detoxifying and repair gene polymorphisms on oxidative stress in ischemic stroke

Expressions of oxidative stress-related genes and antioxidant enzyme activities in Mytilus galloprovincialis (Bivalvia, Mollusca) exposed to hypoxia

GSTM1 polymorphism in patients with clinical manifestations of atherosclerosis

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