Association Analysis Of 5-httlpr Variants, 5-ht2a Receptor Gene 102t/c Polymorphism And Migraine

Juhász, Gabriella; Zsombók, Terézia; Lászik, András; Gonda, Xénia; Sótonyi, Péter; Faludi, Gábor; Bagdy, György

doi:10.1080/714049416

Cited by 28 publications

(52 citation statements)

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“…The shorter allele is associated with slower clearing of serotonin from the synaptic cleft (Schurks et al 2010d). Early studies provided evidence of an association with migraine or MA (Juhasz et al 2003;Marziniak et al 2005). In contrast, Todt et al (Todt et al 2006) conducted a study including this variation and a number of SNPs across the gene and found no association to MA and a recent study by Corominas et al (2010) also confirmed this finding.…”

Section: Neurological Candidate Genesmentioning

confidence: 82%

Identification of molecular genetic factors that influence migraine

Maher

Griffiths

2011

Mol Genet Genomics

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Migraine is a common neurological disorder with a strong genetic basis. However, the complex nature of the disorder has meant that few genes or susceptibility loci have been identified and replicated consistently to confirm their involvement in migraine. Approaches to genetic studies of the disorder have included analysis of the rare migraine subtype, familial hemiplegic migraine with several causal genes identified for this severe subtype. However, the exact genetic contributors to the more common migraine subtypes are still to be deciphered. Genome-wide studies such as genome-wide association studies and linkage analysis as well as candidate genes studies have been employed to investigate genes involved in common migraine. Neurological, hormonal and vascular genes are all considered key factors in the pathophysiology of migraine and are a focus of many of these studies. It is clear that the influence of individual genes on the expression of this disorder will vary. Furthermore, the disorder may be dependent on gene--gene and gene--environment interactions that have not yet been considered. In addition, identifying susceptibility genes may require phenotyping methods outside of the International Classification of Headache Disorders II criteria, such as trait component analysis and latent class analysis to better define the ambit of migraine expression.

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Section: Neurological Candidate Genesmentioning

confidence: 82%

Identification of molecular genetic factors that influence migraine

Maher

Griffiths

2011

Mol Genet Genomics

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“…Yilmaz and colleagues (2001) have also reported that the presence of STin 2.10 allele in this marker may increase the risk of migraine, although the specific differences tended to be contradictory to the results of Ogilvie and colleagues [104]. Juhasz et al (2003) investigated a functional polymorphism in the upstream regulatory region of the serotonin transporter gene in the Hungarian female population. This marker was analysed in 126 migraine sufferers and 101 unrelated healthy controls.…”

Section: Neurotransmitter Functionmentioning

confidence: 88%

“…In a 1996 study at our laboratory Nyholt et al tested two markers in the 5-HT2A by linkage and association analysis and found no evidence for a role of these loci in migraine [117]. A positive association with the 102T/C polymorphism of 5-HT2A and MA was reported by Erdal et al (2001) in a small study group (n = 105) [118]; however, Juhasz et al (2003) found no association with migraine of this particular locus in a larger study sample [105].…”

Section: Neurotransmitter Functionmentioning

confidence: 88%

“…This marker was analysed in 126 migraine sufferers and 101 unrelated healthy controls. A borderline association between the short allele and migraine was found [105]. Marziniak et al (2005) performed an association study in 197 migraineurs and 115 controls investigating the same functional serotonin transporter gene promoter polymorphism.…”

Section: Neurotransmitter Functionmentioning

confidence: 98%

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The search for migraine genes: an overview of current knowledge

Colson

Fernandez

Lea

et al. 2006

Cell. Mol. Life Sci.

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Migraine is a complex familial condition that imparts a significant burden on society. There is evidence for a role of genetic factors in migraine, and elucidating the genetic basis of this disabling condition remains the focus of much research. In this review we discuss results of genetic studies to date, from the discovery of the role of neural ion channel gene mutations in familial hemiplegic migraine (FHM) to linkage analyses and candidate gene studies in the more common forms of migraine. The success of FHM regarding discovery of genetic defects associated with the disorder remains elusive in common migraine, and causative genes have not yet been identified. Thus we suggest additional approaches for analysing the genetic basis of this disorder. The continuing search for migraine genes may aid in a greater understanding of the mechanisms that underlie the disorder and potentially lead to significant diagnostic and therapeutic applications.

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“…Finally, it was suggested that the genetic susceptibility of migraine may be associated with a locus at or near the 5-HT transporter gene [29].…”

Section: Polymorphism Of Genes In the Serotoninergic And Catecholaminmentioning

confidence: 99%

Genetics of fibromyalgia

Buskila

Neumann²

2005

Current Science Inc

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The pathogenesis of fibromyalgia (FM) and related conditions is not entirely understood. Recent evidence suggests that these syndromes may share heritable pathophysiologic features. Familial studies suggest that genetic and familial factors may play a role in the etiopathogenesis of these conditions. There is evidence that polymorphisms of genes in the serotoninergic and catecholaminergic systems are linked to the pathophysiology of FM and related conditions and are associated with personality traits. The precise role of genetic factors in the etiopathology of FM remains unknown, but it is likely that several genes are operating together to initiate this syndrome. Larger longitudinal studies are needed to better clarify the role of genetics in the development of FM.

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Association Analysis Of 5-httlpr Variants, 5-ht2a Receptor Gene 102t/c Polymorphism And Migraine

Cited by 28 publications

References 0 publications

Identification of molecular genetic factors that influence migraine

Identification of molecular genetic factors that influence migraine

The search for migraine genes: an overview of current knowledge

Genetics of fibromyalgia

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