Association Analysis of 5-HTTLPR Variants, 5-Ht2a Receptor Gene 102t/C Polymorphism and Migraine

Juhász, Gabriella; Zsombók, Terézia; Lászik, András; Gonda, Xénia; Sótonyi, Péter; Faludi, Gábor; Bagdy, György

doi:10.1080/718593241

Cited by 29 publications

(21 citation statements)

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“…Another, whose function is not well known, is a variable number tandem repeats (VNTR) of 17-bp sequence in the second intron, with several alleles . This VNTR polymorphism has been implicated in migraine in two studies [Ogilvie et al, 1998;Yilmaz et al, 2001], while the functional promoter polymorphism has been implicated in a female Hungarian population with a borderline association found between the short allele and migraine [Juhasz et al, 2003]. Another investigation of the same functional promoter polymorphism showed that the frequency of the less active short allele was increased in MA sufferers but not in MO sufferers in comparison with the control population [Marziniak et al, 2005].…”

Section: Neurotransmitter-related Genesmentioning

confidence: 94%

Migraine genetics and prospects for pharmacotherapy

Colson

Fernandez

Griffiths

2007

Drug Development Research

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Migraine is a common complex neurological disorder with a well-known but poorly characterized genetic liability. The search for migraine susceptibility genes has been the focus of intense research. It is now believed that common migraine is not a single gene disorder, but attributable to several potentially interacting genetic variants. These variants may differ in each sufferer and interact with environmental factors to set the individual migraine threshold. This genetic liability may play an important role in the clinical heterogeneity seen in migraine and also in the variability of treatment response. This review will look at genetic loci implicated in migraine to date and consider their current or prospective role in migraine therapy. To elucidate the complex nature of migraine genetic liability, approaches that consider detailed endophenotypic profiles that encompass treatment response may provide much more relevant information than simple end diagnosis. Drug Dev Res 68: 282-293, 2007. r 2007 Wiley-Liss, Inc.

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Section: Neurotransmitter-related Genesmentioning

confidence: 94%

Migraine genetics and prospects for pharmacotherapy

Colson

Fernandez

Griffiths

2007

Drug Development Research

View full text Add to dashboard Cite

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“…Not only the genotypes of 5-HT2A but also the level of estrogen could influence the density and protein of the receptor in female brain. Some studies have indicated that the brain serotonergic system is affected by estrogen, and the hormone can increase the density and mRNA level of 5-HT2A receptors in several brain areas 33,34 . It is generally believed that the level of estrogen is significant higher in females.…”

Section: The Canadian Journal Of Neurological Sciences 306mentioning

confidence: 99%

Variations in5-HT2AInfluence Spatial Cognitive Abilities and Working Memory

Gong

Wang

et al. 2011

Can. J. Neurol. Sci.

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5-hydroxytryptamine (5-HT) was described as a modulator interacting with other neurotransmitter systems. The neurotransmitter exerts diverse physiological and pharmacological effects through acting on its multiple receptors. 5-hydroxytryptamine receptor 2A (5-HT2A), a member of the 5-HT receptors, has received considerable attention for its implications in mental diseases and cognitive abilities 1 . The receptor is one of the G protein-coupled serotonin receptors in cerebral cortex 2 . It is involved in the processes of phosphoinositide hydrolysis, which regulates a variety of intracellular signals and controls the differentiation of cells 3 . 5-hydroxytryptamine receptor 2A is expressed at high levels in cerebral cortical areas and at intermediate levels in the hippocampus, nucleus accumbens and the hypothalamus 4 . The postsynaptic activations of receptor in those brain structures may increase during the process of memory 5,6 . The 5-HT2A gene is located 13q14.2. The gene has been considered as one of the antipsychotic drugs targets. Some studies have demonstrated that the gene is associated with schizophrenia, Alzheimer's disease and personality traits [7][8][9] . Recently, direct genetic analyses have identified some functional variants in the gene. The rs6313 was the one of most ABSTRACT: Background: 5-hydroxytryptamine receptor 2A (5-HT2A) participates in diverse psychiatric disorders by regulating the activity of serotonin. Some previous studies have also suggested that the receptor is involved in cognitive abilities of disease groups. We hypothesize that some functional genetic variants in 5-HT2A have certain specific influences on cognitive abilities in a normal population. Method: To confirm this hypothesis, two polymorphisms (rs6313 and rs4941573) in 5-HT2A were selected, and a population-based study was performed in a young healthy Chinese Han cohort. Results: The results indicated that the rs6313 and rs4941573 were associated with touching blocks and mental rotation-3D error ratio in males, and the rs4941573 was associated with visuo-spatial working memory in the whole cohort. Conclusion: All the findings suggest that 5-HT2A participates in human spatial cognitive abilities and spatial working memory.RÉSUMÉ: Des variations du 5-HT2A influencent les habiletés nécessaires à la cognition spatiale et la mémoire à court terme. Contexte : Le récepteur 2A de la 5-hydroxytryptamine (5-HT2A) est impliqué dans la pathogenèse de différentes maladies psychiatriques à cause de son activité sur la sérotonine. Selon certaines études antérieures, il est possible que le récepteur influence les habiletés cognitives dans certains groupes de maladies. Nous avons émis l'hypothèse que des variantes génétiques fonctionnelles du 5-HT2A aient des influences spécifiques sur les habiletés cognitives dans la population normale. Méthode : Deux polymorphismes situés dans le gène 5-HT2A, rs6313 et rs4941573, ont été choisis. Nous avons effectué une étude de population chez une cohorte de jeunes Chinois Han en bonne santé afin de ...

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“…Different studies investigated the role of genetic variations of 5-HT receptors as risk factors for migraine, their role being still not completely understood [3][4][5]. A recent work suggested a link between 5-HTTLPR polymorphism and migraine with aura [6].…”

Section: Introductionmentioning

confidence: 99%