Association analysis of 3p21 with Crohn's disease in a New Zealand population

Autophagy and inflammatory bowel disease: Association between variants of the autophagy-related IRGM gene and susceptibility to Crohn's disease

“…Therefore, similarly to IRGM, reduced function and/or activity of the ULK1 gene could lead to the persistence of intracellular bacteria, resulting in tissue damage and chronic intestinal inflammation. Two studies have already provided evidence for the involvement of ULK1 in the pathogenesis and phenotypes of CD [18,47]. However, in our study we failed to replicate this association.…”

“…Located on chromosome 12q24.3, ULK1 is a serine/threonine kinase, relevant for recruitment and membrane trafficking of Atg proteins and regulatory molecules and subsequent autophagosome formation [47]. Therefore, similarly to IRGM, reduced function and/or activity of the ULK1 gene could lead to the persistence of intracellular bacteria, resulting in tissue damage and chronic intestinal inflammation.…”

Comparative Genetic Analysis of Type 1 Diabetes and Inflammatory Bowel Disease

“…Latiano et al, 2010 confirmed the association of variants (BSN and MST1) at the 3p21 locus influence susceptibility and phenotype both in adults and early-onset patients with IBD. Morgan et al, 2010 replicated the reported association in the 3p21 region with CD in New Zealand population. Metaanalysis by Umeno et al, 2011 confirmed the association of BSN-MST as common susceptibility loci between UC and CD.…”

Phenotype and genotype relationship of glutathione peroxidase1 (GPx1) and rs 1800668 variant: The homozygote effect on kinetic parameters

“…In agreement with our results, several studies have also reported the association between the rs 1800668 genotype distribution and some diseases without the consideration of phenotypes. Morgan et al reported the polymorphic association among patients with Crohn's disease (Morgan et al, 2010). Furthermore, Bhatti et al and Rajaraman et al reported the association of polymorphic site with adult brain tumors (Bhatti et al, 2009;Rajaraman et al, 2008).…”