Association analysis between the MIC-A and HLA-B alleles in Japanese patients with Beh�et's disease

Mizuki, Nobuhisa; Ôta, Masao; Katsuyama, Yoshihiko; Yabuki, Kazuro; Ando, Hitoshi; Goto, Kaori; Nakamura, Satoshi; Bahram, Seiamak; Ohno, Shigeaki; Inoko, Hidetoshi

doi:10.1002/1529-0131(199909)42:9<1961::aid-anr23>3.0.co;2-7

Cited by 87 publications

(64 citation statements)

References 15 publications

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“…HLA-B51 antigen has been well-known genetic factor associated with BD. The prevalence of this antigen in BD appears to be higher in countries adjacent to the ancient silk road including Korea (10,34,35). In the present series, the frequency of HLA-B51 in BD group was significantly higher than that in SpA group.…”

Section: Discussioncontrasting

confidence: 40%

The Comparison Between Behcet's Disease and Spondyloarthritides: Does Behcet's Disease Belong to the Spondyloarthropathy Complex?

et al. 2002

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This study was to clarify whether Beh et's disease (BD) could be classified into the spondyloarthropathy (SpA) complex. It was undertaken on 58 patients with BD (BD group), 56 patients with SpA (SpA group), and 3 patients who concurrently satisfied the criteria for BD and SpA (BDSpA group). The clinical parameters and known susceptible HLA antigens were compared between BD group and SpA group. In addition, 3 patients in BDSpA group were reviewed. The prevalence of definitive sacroiliitis (SI) in BD group and SpA group was 46.4% and 5.2%, respectively. However, none had a definitive SI in healthy controls. Enthesitis was observed in 3.4% of BD group and in 50% of SpA group. The patterns of eye involvement were different between these two groups. HLA-B27 was negative in all 49 patients of BD group, whereas it was positive in 67.9% of SpA group. The prevalence of HLA-B51 was 51.7% in BD group, and that in SpA group was 21.4%. One patient in BDSpA group was considered to have concurrent BD and ankylosing spondylitis (AS). Another patient was closer to AS, and the third to BD. Conclusively, it seems that BD could not be classified into the SpA complex.

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Section: Discussioncontrasting

confidence: 40%

The Comparison Between Behcet's Disease and Spondyloarthritides: Does Behcet's Disease Belong to the Spondyloarthropathy Complex?

et al. 2002

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“…HLA-B51 may be the strongest indicator that certain genes are directly responsible for BD (11,15). Prominent association of HLA-B51 with BD in many different ethnic groups was reported (3,13,14).…”

Section: Resultsmentioning

confidence: 99%

The Tumor Necrosis Factor-A (TNF-A) Gene -308 G/A Polymorphism and the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (Trail) Gene Polymorphisms in Behcet'S Disease

Isi

Akdeniz

Oral

et al. 2010

Biotechnology & Biotechnological Equipment

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“…[26][27][28] Also, MICA006 (MHC class I chain related gene A) gene, which lies directly beside the HLA-B51 gene on chromosome 6, was found in ABD patients. 29,30 It is unknown whether the gene product has a pathological effect or it enables an autoimmune reaction triggered by a pathogen similar to HLA-B, so that it is not detected and eliminated by the immune system. One example is the retinal S antigen, a retinal protein that is found only after tissue destruction following uveitis and triggers T-cell response.…”

Section: Discussionmentioning

confidence: 99%

Ocular involvement is associated with HLA-B51 in Adamantiades–Behçet's disease

Krause

Altenburg

et al. 2008

Eye

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Purpose To evaluate the association of HLA-B51 and ocular involvement in Adamantiades-Behçet's disease. Methods We retrospectively analysed all patients with Adamantiades-Behçet's disease examined in our Department of Ophthalmology since 1982. All patients fulfilled the criteria of the International Study Group for Behçet's disease. We included 140 patients (63 female and 77 male) with a mean follow-up of 6.4 years. Results The mean age at the first manifestation was 23 years; full disease was noted at 32 years. The mean age at the time of eye involvement was 30 years. Most of the patients were of Turkish (n ¼ 73) or German (n ¼ 34) origin. A total of 56% patients developed eye involvement. Forty-nine out of 76 HLA-B51-positive patients (64.5%) and 26 out of 60 HLA-B51-negative patients (43.3%; P ¼ 0.014) developed ocular involvement. Conclusion More than the half of the patients with Adamantiades-Behçet's disease evaluated in our department developed ocular involvement. There was a statistically significantly higher frequency of HLA-B51 in these patients.

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Association analysis between the MIC-A and HLA-B alleles in Japanese patients with Beh�et's disease

Abstract: These results imply that the real disease susceptibility gene involved in the development of Behçet's disease is the HLA-B51 allele itself and that the significant increase of the MIC-A009 allele in the patient group results secondarily from a strong linkage disequilibrium with HLA-B51.

Cited by 87 publications

References 15 publications

The Comparison Between Behcet's Disease and Spondyloarthritides: Does Behcet's Disease Belong to the Spondyloarthropathy Complex?

The Comparison Between Behcet's Disease and Spondyloarthritides: Does Behcet's Disease Belong to the Spondyloarthropathy Complex?

The Tumor Necrosis Factor-A (TNF-A) Gene -308 G/A Polymorphism and the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (Trail) Gene Polymorphisms in Behcet'S Disease

Ocular involvement is associated with HLA-B51 in Adamantiades–Behçet's disease

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