Association analysis betweenMDR1gene polymorphisms and risk of hepatocellular carcinoma in Chinese population

Abstract

The objective of this study was to evaluate the association between MDR1 gene polymorphisms and hepatocellular carcinoma (HCC) risk. Genomic DNA of 1431 subjects was extracted from peripheral blood and genotyping was performed using the created restriction site-polymerase chain reaction (CRS-PCR). We found that the c.1465C > T single nucleotide polymorphisms (SNP) increased HCC risk in all genetic models (p < 0.05) and the allele-T of c.1465C > T may contribute to the risk of HCC. No significantly increased HCC risk was detected in c.159G > T SNP. Our data indicated that the genetic variants of MDR1 gene may be a valuable molecular marker for HCC.

Association Between the c.3751G>A Genetic Variant of MDR1 and Hepatocellular Carcinoma Risk in a Chinese Han Population

“…Therefore, Chen et al, indicated that the C3435T polymorphism may be a positive candidate molecular marker for the prognosis of HCC (Chen et al, 2011). Yang et al (2013) found that the c.1465C>T polymorphism may contribute to the risk of HCC, while no significantly increased HCC risk was detected in c.159G>T polymorphism (Yang et al, 2013). However, results from these observations remain conflicting rather than conclusive.…”

“…It has been reported that the MDR1 gene is regarded as one of the most important candidate genes for influencing on the susceptibility to HCC. The potential associations between several MDR1 genetic polymorphisms and HCC susceptibility have been assessed (Wu et al, 2007;Chen et al, 2009;Chen et al, 2011;Ren et al, 2012;Gao, 2013;Yang et al, 2013). Wu and his colleagues reported that the MDR1 gene polymorphisms (such as C1236T, G2677A/T, and C3435T) could be valuable molecular markers for HCC recurrence after liver transplantation (Wu et al, 2007).…”

“…MDR1 is a polymorphic gene and several genetic variants, such as G159T, T335C, C1236T, C1465T, G2677A/T, C3435T, A3073C, and A4125C, have been reported to have potential association with the risk of HCC (Cavaco et al, 2003;Pechandova et al, 2006;Wu et al, 2007;Vander Borght et al, 2008;Chen et al, 2009;Chen et al, 2011;Yu et al, 2011;Ren et al, 2012;Gao, 2013;Yang et al, 2013). Among of these studies, several MDR1 genetic polymorphisms have been approved to play an important genetic affection on HCC risk (Wu et al, 2007;Chen et al, 2009;Chen et al, 2011;Ren et al, 2012;Gao, 2013;Yang et al, 2013). Up to now, there are no similar studies which reported the association between c.3751G>A genetic variant of MDR1 gene and HCC risk.…”

“…Previous studies indicated that the multidrug resistance 1 gene (MDR1) is one of the most important candidate genes which have potentially influence on HCC risk (Wu et al, 2007;Vander Borght et al, 2008;Chen et al, 2009;Chen et al, 2011;Yu et al, 2011;Ren et al, 2012;Gao, 2013;Yang et al, 2013). MDR1 is a polymorphic gene and several genetic variants, such as G159T, T335C, C1236T, C1465T, G2677A/T, C3435T, A3073C, and A4125C, have been reported to have potential association with the risk of HCC (Cavaco et al, 2003;Pechandova et al, 2006;Wu et al, 2007;Vander Borght et al, 2008;Chen et al, 2009;Chen et al, 2011;Yu et al, 2011;Ren et al, 2012;Gao, 2013;Yang et al, 2013). Among of these studies, several MDR1 genetic polymorphisms have been approved to play an important genetic affection on HCC risk (Wu et al, 2007;Chen et al, 2009;Chen et al, 2011;Ren et al, 2012;Gao, 2013;Yang et al, 2013).…”

Association between the c.1564A>T genetic polymorphism of the MDR1 gene and hepatocellular carcinoma in Chinese population

“…Previous studies reported that the multidrug resistance 1 gene (MDR1) is an important candidate gene influencing HCC (Wu et al, 2007;Vander Borght et al, 2008;Chaijaroenkul et al, 2011;Chen et al, 2009Chen et al, , 2011Geng et al, 2011;Yu et al, 2011;Ren et al, 2012;Sun et al, 2012;Gao, 2013;Li et al, 2013;Yang et al, 2013). MDR1 is a polygenetic gene and many genetic polymorphisms, such as G159T, T335C, C1236T, C1465T, G2677A/T, C3435T, A3073C, and A4125C, have been reported to have possible associations with the risk of HCC (Cavaco et al, 2003;Pechandova et al, 2006;Wu et al, 2007;Vander Borght et al, 2008;Chen et al, 2009Chen et al, , 2011Yu et al, 2011;Ren et al, 2012;Gao, 2013;Yang et al, 2013). Several studies suggested that MDR1 genetic polymorphisms influenced HCC risk (Wu et al, 2007;Chen et al, 2009Chen et al, , 2011Ren et al, 2012;Gao, 2013;Yang et al, 2013).…”