Association Analysis Between 12 Genetic Variants of Ten Genes and Personality Traits in a Young Chinese Han Population

Gong, Pingyuan; Zheng, Anyun; Zhang, Kejin; Liu, Xu; Li, Fengchao; Chen, Dongmei; Chi, Wen‐Rong; Xue-li, Tong; Zheng, Zijian; Gao, Xiaocai; Zhang, Fuchang

doi:10.1007/s12031-010-9373-6

Cited by 9 publications

(10 citation statements)

References 41 publications

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“…The allele frequencies of COMT and TPH2 in this study (COMT Met allele: 25.0%; TPH2 G allele: 47.3%) were similar to those in other Asian populations (Chen et al, 2011, Gong et al, 2010, Kim et al, 2009, Lin et al, 2007, Zhang et al, 2011 but different from Caucasian populations (COMT Met allele: 52.0%; TPH2 G allele: 71.3%) (Drabant et al, 2006, Osinsky et al, 2009. The allele frequency of COMT was in accordance with Hardy-Weinberg Equilibrium (P = 0.870), but not for TPH2 (P = 0.015).…”

Section: Clinical Characteristics and Genotypessupporting

confidence: 86%

Synergistic Effects of COMT and TPH2 on Social Cognition

Lin¹,

Tseng²,

Huang³

et al. 2013

Psychiatry: Interpersonal and Biological Processes

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Whether genetic factors affect social cognition, particularly emotion management, requires elucidation. This study investigates whether social cognition varies with genetic variations of COMT and tryptophan hydroxylase-2 (TPH2), which modulate dopamine and serotonin neurotransmissions respectively, and thereby emotion regulation. NIMH-recommended "managing emotions branch and 2 subtasks" of MSCEIT and six neurocognition domains, and genotypes of COMT Val158Met and TPH2 G703T were measured in 150 Han-Chinese healthy adults. Subjects carrying the M allele (M group) of COMT exceeded Val/Val homozygotes (V group) in managing emotions branch (p = 0.032) and emotional relation subtask (p = 0.037). TPH2 T/T homozygotes (T group) excelled those with the G allele (G group) in emotional management subtask (p = 0.025). Subjects with M+T variation surpassed the other 3 groups (M+G, V+T and V+G) in managing emotion branch (p = 0.002), emotional relation subtask (p = 0.023), and emotional management subtask (p = 0.002). The findings remained after control for gender, age, education, and neurocognitive functions. Synergistically, the effect size of COMT-TPH2 combination surmounted the sum of separate effect sizes of COMT and TPH2. The findings suggest that genetic variations of COMT and TPH2 have synergistic effects on social cognition in the general population.

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Section: Clinical Characteristics and Genotypessupporting

confidence: 86%

Synergistic Effects of COMT and TPH2 on Social Cognition

Lin¹,

Tseng²,

Huang³

et al. 2013

Psychiatry: Interpersonal and Biological Processes

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“…These motivated researchers to search for genes for personality traits. Till now, several candidate genes/loci may be associated with personality traits, including COMT, CPY, DA, DARPP-32, DRD2, DRD3, DRD4, 5-HT, 5-HTTLPR, FYN, HTR2A, MAOA, SERT, TH, and TPH (Benjamin et al 2002;Reif and Lesch 2003;Savitz and Ramesar 2004;Ebstein 2006;Heck et al 2009;Gong et al 2010;Li et al 2011a, b).…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in ABLIM1 are Associated with Personality Traits and Alcohol Dependence

Wang

Aragam

et al. 2011

J Mol Neurosci

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Personality traits like novelty seeking (NS), harm avoidance (HA), and reward dependence (RD) are known to be moderately heritable (30-60%). These personality traits and their comorbidities, such as alcohol dependence (AD), may share genetic components. We examined 11,120 single nucleotide polymorphisms (SNPs) genotyped in 292 nuclear families from the Genetic Analysis Workshop 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). A family-based association analysis was performed using the FBAT program. NS, HA, and RD were treated as quantitative traits and AD as a binary trait. Based on a multivariate association test of three quantitative traits in FBAT, we observed 20 SNPs with p < 10(-3). Interestingly, several genes (TESK2, TIPARP, THEMIS, ABLIM1, RFX4, STON2 and LILRA1) are associated with three personality traits with p < 10(-3) using single trait analysis and AD. Especially, SNP rs727532 within ABLIM1 gene at 10q25 showed the most significant association (p = 6.4 × 10(-5)) in the multivariate test and strong associations with NS, HA, RD, and AD (p = 4.48 × 10(-4), 1.2 × 10(-5), 5.6 × 10(-5), 3.12 × 10(-4), respectively) in the COGA sample. In addition, the association of rs727532 with AD was confirmed in a replication study. This study reports some newly recognized associations between several genetic loci and both AD and three personality traits.

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“…The gene has been considered as one of the antipsychotic drugs targets. Some studies have demonstrated that the gene is associated with schizophrenia, Alzheimer's disease and personality traits [7][8][9] . Recently, direct genetic analyses have identified some functional variants in the gene.…”

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confidence: 99%

Variations in5-HT2AInfluence Spatial Cognitive Abilities and Working Memory

Gong

Wang

et al. 2011

Can. J. Neurol. Sci.

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5-hydroxytryptamine (5-HT) was described as a modulator interacting with other neurotransmitter systems. The neurotransmitter exerts diverse physiological and pharmacological effects through acting on its multiple receptors. 5-hydroxytryptamine receptor 2A (5-HT2A), a member of the 5-HT receptors, has received considerable attention for its implications in mental diseases and cognitive abilities 1 . The receptor is one of the G protein-coupled serotonin receptors in cerebral cortex 2 . It is involved in the processes of phosphoinositide hydrolysis, which regulates a variety of intracellular signals and controls the differentiation of cells 3 . 5-hydroxytryptamine receptor 2A is expressed at high levels in cerebral cortical areas and at intermediate levels in the hippocampus, nucleus accumbens and the hypothalamus 4 . The postsynaptic activations of receptor in those brain structures may increase during the process of memory 5,6 . The 5-HT2A gene is located 13q14.2. The gene has been considered as one of the antipsychotic drugs targets. Some studies have demonstrated that the gene is associated with schizophrenia, Alzheimer's disease and personality traits [7][8][9] . Recently, direct genetic analyses have identified some functional variants in the gene. The rs6313 was the one of most ABSTRACT: Background: 5-hydroxytryptamine receptor 2A (5-HT2A) participates in diverse psychiatric disorders by regulating the activity of serotonin. Some previous studies have also suggested that the receptor is involved in cognitive abilities of disease groups. We hypothesize that some functional genetic variants in 5-HT2A have certain specific influences on cognitive abilities in a normal population. Method: To confirm this hypothesis, two polymorphisms (rs6313 and rs4941573) in 5-HT2A were selected, and a population-based study was performed in a young healthy Chinese Han cohort. Results: The results indicated that the rs6313 and rs4941573 were associated with touching blocks and mental rotation-3D error ratio in males, and the rs4941573 was associated with visuo-spatial working memory in the whole cohort. Conclusion: All the findings suggest that 5-HT2A participates in human spatial cognitive abilities and spatial working memory.RÉSUMÉ: Des variations du 5-HT2A influencent les habiletés nécessaires à la cognition spatiale et la mémoire à court terme. Contexte : Le récepteur 2A de la 5-hydroxytryptamine (5-HT2A) est impliqué dans la pathogenèse de différentes maladies psychiatriques à cause de son activité sur la sérotonine. Selon certaines études antérieures, il est possible que le récepteur influence les habiletés cognitives dans certains groupes de maladies. Nous avons émis l'hypothèse que des variantes génétiques fonctionnelles du 5-HT2A aient des influences spécifiques sur les habiletés cognitives dans la population normale. Méthode : Deux polymorphismes situés dans le gène 5-HT2A, rs6313 et rs4941573, ont été choisis. Nous avons effectué une étude de population chez une cohorte de jeunes Chinois Han en bonne santé afin de ...

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Association Analysis Between 12 Genetic Variants of Ten Genes and Personality Traits in a Young Chinese Han Population

Cited by 9 publications

References 41 publications

Synergistic Effects of COMT and TPH2 on Social Cognition

Synergistic Effects of COMT and TPH2 on Social Cognition

Polymorphisms in ABLIM1 are Associated with Personality Traits and Alcohol Dependence

Variations in5-HT2AInfluence Spatial Cognitive Abilities and Working Memory

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