Association among β2‐adrenergic receptor autoantibodies and proximal left anterior descending artery lesions in patients with initial ST‐segment elevation myocardial infarction

Abstract

Backgroundβ2‐adrenergic receptor autoantibody (β2‐AA) are widely present in patients with many different types of cardiovascular diseases. Proximal left anterior descending (LAD) artery lesions are associated with adverse prognostic events in patients with ST‐segment elevation myocardial infarction (STEMI).Hypothesisβ2‐AA is associated with the presence of proximal LAD lesions in patients with STEMI.MethodsA cohort of 153 patients with STEMI who underwent primary percutaneous coronary intervention (PPCI) was enrolled in the study. Baseline characteristics were compared between the proximal LAD group (n = 62) and the nonproximal LAD group (n = 91). Admission serum of patients was collected to detect the level of β2‐AA. Data for echocardiogram within 24 hours after PPCI and at the 6‐month follow‐up were recorded.ResultsThe optical density values and positive rates of β2‐AA in the proximal LAD group were higher than those in the nonproximal LAD group (p < 0.05). β2‐AA positively correlated with high sensitivity C‐reactive protein and peak N‐terminal pro‐B type natriuretic peptide levels in the proximal LAD group, but those were not relevant in the nonproximal LAD group. Multivariate logistic regression analysis revealed that high β2‐AA levels was independently associated with the presence of proximal LAD lesions in patients with STEMI. Furthermore, a receiver operating characteristic curve was used to show the efficiency of β2‐AA levels to detect proximal LAD lesions, and the AUC of the β2‐AA OD value was 0.658 (95% confidence interval 0.568−0.749; p = 0.001).ConclusionsThe STEMI patients with high β2‐AA levels had a greater possibility having proximal LAD lesions.