Association among mild cognitive impairment, social frailty, and clinical events in elderly patients with cardiovascular disease

Adachi, Takuji; Tsunekawa, Yuki; Tanimura, Daisuke

doi:10.1016/j.hrtlng.2022.04.011

Cited by 15 publications

(7 citation statements)

References 35 publications

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“… 8 Ono et al 26 * 2021 Prospect 53 months Japan 181/Patients with GC; 139 males and 42 females; age, 72.0 years The risk of mortality in patients with GC was higher in those experiencing SF after adjusting for confounding factors (HR, 3.23). 7 Adachi et al 27 * 2022 Retro 12 months Japan 184/Hospitalized elderly patients with CVD; 122 males and 62 females; age, 75.0 years The risk of all-cause clinical events, including all-cause mortality was not significantly higher in those experiencing SF (HR: 1.41). 7 All-cause mortality or functional disability Yamada and Arai 28 2018 Prospect 72 months Japan 6603/2911 males and 3692 females; age, 75.2 ± 6.6 years The risk of incident disability and all-cause mortality was higher in those experiencing SF (HR: 1.28).…”

Section: Resultsmentioning

confidence: 98%

“…Participants in these studies were community-dwelling older individuals. Jujo et al 25 and Ono et al 26 studied patients with heart failure and gastrointestinal cancer, respectively, whereas Adachi et al 27 studied hospitalized patients with cardiovascular disease. Considering the impact of social frailty on all-cause mortality, four of the six articles reported a significant association, whereas two articles concluded that there was no significant association.…”

Section: Resultsmentioning

confidence: 99%

“…2 A. Since all six reports 22 – 27 that were qualitatively integrated in all-cause mortality had hazard ratios, we attempted to integrate the meta-analyses of these reports quantitatively. Considering the impact of social frailty on all-cause mortality, the hazard ratio was 1.96 (95% CI 1.20–3.19), indicating a significant association between the two but high heterogeneity (I 2 = 88%, p < 0.05).…”

Section: Resultsmentioning

confidence: 99%

“…High heterogeneity could weaken the evidence for the results obtained in the meta-analysis, and caution should be exercised when interpreting these results. This high heterogeneity can be explained by the fact that four of the six reports on all-cause mortality showed significant associations, while two reports, those of Gobbens et al 24 and Adachi et al 27 , did not show significant associations; the results were inconsistent. This inconsistency could be attributed to the variation in the assessment tools for social frailty in the studies: three of the six reports used the Makizako index, and one report each used the TFI, Garre-Olmo's index, and the HALFT scale.…”

Section: Discussionmentioning

confidence: 98%

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Social frailty as a predictor of all-cause mortality and functional disability: a systematic review and meta-analysis

Goto,

Kishimoto,

Fujiwara

et al. 2024

Sci Rep

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The association between social frailty and adverse health outcomes, especially mortality and functional disability, which are essential health outcomes, has not been systematically summarized or meta-analyzed. In this study, we conducted a systematic review and meta-analysis of the impact of social frailty on all-cause mortality and functional disability, while addressing the components of social frailty. In this study, social frailty was operationally defined in alignment with the previous literature, as follows: “a state of increased vulnerability to the interactive back-and-forth of the community, including general resources, social resources, social behaviors, and needs.” Hazard ratios or odds ratios described in each selected literature were used as the meta-analytic results. Considering the impact of social frailty on all-cause mortality, the hazard ratio was 1.96 (95% CI 1.20–3.19), indicating a significant association between the two but high heterogeneity. The hazard and odds ratios for the impact of social frailty on functional disability were 1.43 (95% CI 1.20–1.69) and 2.06 (95% CI 1.55–2.74), respectively. A significant association was found between social frailty and functional disability; both hazard and odds ratios were found, and low heterogeneity between these articles was observed. These results highlight the importance of assessing social frailty using more standardized methods and examining its effects on various health outcomes.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

See 2 more Smart Citations

Social frailty as a predictor of all-cause mortality and functional disability: a systematic review and meta-analysis

Goto,

Kishimoto,

Fujiwara

et al. 2024

Sci Rep

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“…A prediction model ( 16) for NSCLC after radiotherapy has been proposed and predicts patient survival at 6 months, 1 year, As people continue to age, changes in the physiology and pathology of the elderly patient's organism are influenced by a number of factors, particularly physiological changes in the cardiovascular and respiratory systems (20,21). This is mainly reflected in the reduced catecholamine response to stress, significantly reduced cardiac output, reduced lung tissue compliance, reduced expiratory effort and reduced pulmonary ventilation-perfusion capacity in elderly patients (22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

Construction of a mortality risk prediction model for elderly people at risk of lobectomy for NSCLC

Zhang

Ren²,

Cheng

et al. 2023

Front. Surg.

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BackgroundAn increasing number of lung cancer patients are opting for lobectomy for oncological treatment. However, due to the unique organismal condition of elderly patients, their short-term postoperative mortality is significantly higher than that of non-elderly patients. Therefore, there is a need to develop a personalised predictive tool to assess the risk of postoperative mortality in elderly patients.MethodsInformation on the diagnosis and survival of 35,411 older patients with confirmed lobectomy NSCLC from 2009 to 2019 was screened from the SEER database. The surgical group was divided into a high-risk mortality population group (≤90 days) and a non-high-risk mortality population group using a 90-day criterion. Survival curves were plotted using the Kaplan-Meier method to compare the differences in overall survival (OS) and lung cancer-specific survival (LCSS) between the two groups. The data set was split into modelling and validation groups in a ratio of 7.5:2.5, and model risk predictors of postoperative death in elderly patients with NSCLC were screened using univariate and multifactorial logistic regression. Columnar plots were constructed for model visualisation, and the area under the subject operating characteristic curve (AUC), DCA decision curve and clinical impact curve were used to assess model predictiveness and clinical utility.ResultsMulti-factor logistic regression results showed that sex, age, race, histology and grade were independent predictors of the risk of postoperative death in elderly patients with NSCLC. The above factors were imported into R software to construct a line graph model for predicting the risk of postoperative death in elderly patients with NSCLC. The AUCs of the modelling and validation groups were 0.711 and 0.713 respectively, indicating that the model performed well in terms of predictive performance. The DCA decision curve and clinical impact curve showed that the model had a high net clinical benefit and was of clinical application.ConclusionThe construction and validation of a predictive model for death within 90 days of lobectomy in elderly patients with lung cancer will help the clinic to identify high-risk groups and give timely intervention or adjust treatment decisions.

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Older Adults with Cardiovascular Disease: Linking in Cognitive Impairments

Adachi

2024

Handbook of the Behavior and Psychology of Disease

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Association among mild cognitive impairment, social frailty, and clinical events in elderly patients with cardiovascular disease

Cited by 15 publications

References 35 publications

Social frailty as a predictor of all-cause mortality and functional disability: a systematic review and meta-analysis

Social frailty as a predictor of all-cause mortality and functional disability: a systematic review and meta-analysis

Construction of a mortality risk prediction model for elderly people at risk of lobectomy for NSCLC

Older Adults with Cardiovascular Disease: Linking in Cognitive Impairments

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