Association among interleukin‐6 gene polymorphisms, type 2 diabetes mellitus, and chronic periodontitis: a pilot study

Kavitha, Loganathan; Priyadharsini, J. Vijayashree; Sivapathasundharam, B

doi:10.1111/jicd.12230

Cited by 10 publications

(6 citation statements)

References 28 publications

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“…The associations between this type of polymorphism and PD have been confirmed in studies and meta-analyses [75][76][77][78][79][80]. In 2009, Shao et al presented the relationship between the IL-6 174 G/C polymorphism and periodontitis as initial meta-analysis results and proved that the GG genotype is related to a high risk of periodontitis, which was confirmed by numerous other reports.…”

Section: Interleukin-6-174g/c Polymorphism In Periodontitismentioning

confidence: 72%

The Role of Interleukin 6 in Periodontitis and Its Complications

Mazurek-Mochol,

Bonsmann,

Mochol

et al. 2024

IJMS

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Interleukin 6 (IL-6) is a pleomorphic pro-inflammatory cytokine that is strongly associated with local as well as systemic inflammatory processes. Its role in physiological and pathogenic processes throughout the human body has been the subject of numerous studies in recent years. Measurements of the IL-6 levels in gingival crevicular fluid (GFC), as well as in serum, can be important diagnostic and prognostic factors in periodontal diseases (PD) and in assessing their impact on a range of related inflammatory diseases. This narrative review explores the significant role of IL-6 in patients with periodontitis and its association with other widespread inflammatory pathologies.

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Section: Interleukin-6-174g/c Polymorphism In Periodontitismentioning

confidence: 72%

The Role of Interleukin 6 in Periodontitis and Its Complications

Mazurek-Mochol,

Bonsmann,

Mochol

et al. 2024

IJMS

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“…Já foi demonstrado que pacientes com DM2 apresentam concentrações plasmáticas elevadas de IL-6, particularmente aqueles com características da síndrome de RI. Uma interpretação para esse dado é que, no DM2 e na RI, há uma resposta de fase aguda devido ao aumento de IL-6 derivada da secreção imune ou do tecido adiposo, que não sofre restrição e que atua em adipócitos hipersensíveis 30 . De fato, há dados mostrando que as concentrações plasmáticas de marcadores de fase aguda estão aumentadas nessas condições, como PCR, proteína amiloide sérica A, alfa 1 glicoproteína ácida, ácido siálico e cortisol 31 .…”

Section: Discussionunclassified

Correlação entre a concentração sérica de interleucina-6 (IL-6) e biomarcadores de resistência insulínica em adultos jovens obesos

Oliboni¹,

Casarin²,

Chielle³

2016

cbr

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RESUMOIntrodução: O tecido adiposo é um importante órgão endócrino secretor de adipocinas como a interleucina-6 (IL-6), que estimula a produção de proteínas de fase aguda no fígado, conduzindo a um estado inflamatório subclínico associado ao surgimento de comorbidades presentes na obesidade, como a resistência à insulina (RI). O objetivo deste estudo foi avaliar a concentração de IL-6 em jovens obesos, com sobrepeso e de peso normal, correlacionando as concentrações dessa citocina com biomarcadores de RI. Métodos:Foi conduzido um estudo transversal que envolveu 149 indivíduos: 54 saudáveis (32 mulheres e 22 homens), 27 com sobrepeso (17 mulheres e 10 homens) e 68 obesos (41 mulheres e 27 homens). As medidas antropométricas e as concentrações de IL-6, insulina, hemoglobina glicada e glicose foram determinadas, assim como os cálculos do Modelo de Avaliação da Homeostase (HOMA) e da sensibilidade insulínica (SI).Resultados: Pacientes obesos mostraram níveis de IL-6, glicose, insulina e HOMA significativamente superiores e redução da SI quando comparados com pacientes de peso normal. Correlações positivas foram observadas entre IL-6, glicose, insulina e HOMA. Conclusão:Este estudo sugere que a IL-6 pode ter um papel-chave no desenvolvimento da RI em obesos e que o aumento de sua produção pode contribuir para a inflamação do tecido adiposo e interferir significativamente na atividade da insulina. Embora mais estudos clínicos sejam necessários para elucidar os reais mecanismos de interferência da IL-6 sobre a SI, sugere-se que essa citocina poderá ser, no futuro, uma determinação importante para avaliar e monitorar a RI em obesos jovens. Palavras-chave: Citocina; obesidade; diabetes; insulina ABSTRACTIntroduction: Adipose tissue is a major endocrine organ responsible for secretion of adipokines, such as interleukin-6 (IL-6), which stimulates the production of acute phase proteins in the liver, leading to a proinflammatory condition associated with the development of comorbidities in obesity, such as insulin resistance (IR). The aim of this study was to evaluate the IL-6 concentration in obese, overweight, and normal-weight young adults, correlating the concentrations of this cytokine with IR biomarkers.

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“…According to the study flowchart (Figure 1), a total of 147 articles were included in the final meta-analysis on genetic polymorphism in the 12 cytokine genes (Th1 (IL-2, IFN-g, and TNF-a), Th2 (IL-4 and IL-13), Th17 (IL-1a, IL-1b, IL-6, TGF-b, and IL-17), and Treg cytokines (IL-10 and TGF-b)), including IL-1a (12-28), IL-1b (12,16,18,24,, IL-2 (56-60), IL-4 (61-73), IL-6 (74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)145), 42,[84][85][86][88][89][90][91][92][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107]109,110,118,146,147), IL-13 (66,…”

Section: Study Selectionmentioning

confidence: 99%

“…Many studies have proven gene polymorphisms in cytokines such as IL-1a (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28), IL-1b (12,16,18,24,, IL-2 (56)(57)(58)(59)(60), IL-4 (61-73), IL-6 (74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86), IL-23 (87), 42,[84][85][86], IL-13 (66,111,112), IL-17 (60,73,87,(113)(114)…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review and Meta-Analysis on Multiple Cytokine Gene Polymorphisms in the Pathogenesis of Periodontitis

Liu

2022

Front. Immunol.

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AimPeriodontitis is an inflammatory disease that destroys both soft and hard periodontal tissues. However, a complex periodontal cytokine network remains unclear. This systematic review explored multiple cytokine gene polymorphisms in the pathogenesis of periodontitis.Material and MethodsA systematic search was performed using the databases from previous publications, which indicated the association between cytokine polymorphisms and periodontitis pathogenesis. Meta-analysis was conducted using fixed or randomized models to calculate the significance of multiple cytokine polymorphisms. A total of 147 articles were analyzed with polymorphisms in 12 interleukins [Th1 (IL-2, IFN-γ, and TNF-α), Th2 (IL-4 and IL-13), Th17 (IL-1α, IL-1β, IL-6, and IL-17), and Treg cytokines (IL-10 and TGF-β)]. Doi plot was used to probe the occurrence of publication bias.ResultsThe polymorphisms of IL-2 and TNF-α of Th1 cytokine family may be associated with the pathogenesis or the prevention of periodontitis risk, while the polymorphism of IFN-γ is not related to periodontitis risk. The polymorphisms for IL-4 and IL-13 of Th2 cytokine family are not found to be associated with the pathogenesis of periodontitis. For the polymorphisms of the members of Th17 cytokine family, different IL-1α polymorphisms may have inverse actions in the pathogenesis of periodontitis. IL-1β is a noteworthy cytokine biomarker in periodontitis development and progression. IL-6 may have a protective function in the inflammatory responses of periodontitis, and IL-17 has a weak relationship the inflammatory responses. The polymorphisms for the members of Treg cell cytokines may have a protective function against periodontitis risk. LFK indexes show the major asymmetry due to publication bias.ConclusionIL-1β is a notable cytokine biomarker in periodontitis risk. Treg cytokines favor an anti-inflammatory and protective environment. Further data are needed to confirm the present conclusion due to publication bias.

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Association among interleukin‐6 gene polymorphisms, type 2 diabetes mellitus, and chronic periodontitis: a pilot study

Abstract: The GC genotype was found to be the risk genotype and the C allele was found to be the risk allele for the development of CP.

Cited by 10 publications

References 28 publications

The Role of Interleukin 6 in Periodontitis and Its Complications

The Role of Interleukin 6 in Periodontitis and Its Complications

Correlação entre a concentração sérica de interleucina-6 (IL-6) e biomarcadores de resistência insulínica em adultos jovens obesos

A Systematic Review and Meta-Analysis on Multiple Cytokine Gene Polymorphisms in the Pathogenesis of Periodontitis

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