Association Among Complete Blood Count Parameters, Bone Mineral Density, and Cobb Angle in Cases of Adolescent Idiopathic Scoliosis

Bala, Mehmet Murat; Bala, Keziban Aslı

doi:10.12659/msm.940355

Cited by 2 publications

(3 citation statements)

References 59 publications

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“…Scoliosis was defined as a spinal curvature with a Cobb angle of 10° or greater. Measurements were made using the classical vertebra endplate method using erect and bending radiographs [ 1 ].…”

Section: Methodsmentioning

confidence: 99%

“…Adolescent idiopathic scoliosis (AIS) represents a complex 3-dimensional structural disorder affecting the spine. It appears in children, predominantly between the age of 10 years and the end of their skeletal maturity [ 1 ]. A myriad of factors, including genetic, intrinsic, and environmental elements, play a critical role in the onset and progression of AIS.…”

Section: Introductionmentioning

confidence: 99%

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Pubertal Stage-Dependent Anthropometric Variations in Turkish Children with Adolescent Idiopathic Scoliosis: An In-Depth Analysis

Bala

2023

Med Sci Monit

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Background Identifying predictive factors for anthropometric changes during puberty in adolescent idiopathic scoliosis (AIS) is critical for prognosis and management. This study aimed to discern these factors in the Turkish AIS population, by analyzing variations against female breast development stages and male testicular volume, benchmarked against national standards. Material/Methods A cross-sectional study was conducted between 2018 and 2022, involving children aged 10 to 18 years from the Orthopedics and Pediatrics Clinics. AIS patients and controls were assessed concerning pubertal status (Tanner stage), chronological age, skeletal maturation (Tanner-Whitehouse), and anthropometric parameters (height, weight, and body mass index). Results AIS patients were compared to controls, stratified by pubertal stages. In girls across all stages, significant differences emerged in bone age, BMI, and weight between AIS and controls ( p <0.01). In boys, AIS patients significantly differed in bone age from controls across all stages ( p <0.001). At stage V, controls demonstrated higher BMI than AIS boys ( p <0.001), while at stage I, AIS boys had significantly higher height and weight compared to controls ( p <0.001). Conclusions AIS patients demonstrate distinctive pubertal growth abnormalities, with males and females presenting divergent patterns. Understanding these variations could inform better management of AIS during the critical pubertal growth period.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pubertal Stage-Dependent Anthropometric Variations in Turkish Children with Adolescent Idiopathic Scoliosis: An In-Depth Analysis

Bala

2023

Med Sci Monit

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“…The findings revealed a significant correlation between PLR and the Cobb angle, as well as an association between vitamin D deficiency and low BMD. Additionally, the authors reported that complete blood count parameters can serve as predictors for BMD in adolescents ( 27 ). In contrast to their findings, our study did not identify a significant relationship between these biochemical markers and BMD.…”

Section: Discussionmentioning

confidence: 99%

Quantitative computed tomography assessment of bone mineral density in adolescent idiopathic scoliosis: correlations with Cobb angle, vertebral rotation, and Risser sign

Li,

Gao,

Zhao

et al. 2024

Transl Pediatr

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Background Adolescent idiopathic scoliosis (AIS) is a prevalent spinal disorder that can potentially influence bone mineral density (BMD), thereby increasing the susceptibility to osteoporosis and fractures. Early identification of reduced bone mass in AIS patients is crucial for clinicians to develop effective preventive strategies against fractures. This study aims to elucidate the correlation between BMD, as measured by quantitative computed tomography (QCT), and various clinical parameters in AIS, including the Cobb angle, vertebral rotation, and the Risser sign. By revealing the potential influences of these factors on BMD, our findings aim to assist clinicians in making informed and timely decisions regarding AIS management, particularly in situations where QCT is unavailable. Methods A cross-sectional study was conducted on 129 adolescents with AIS who were enrolled at The Third People’s Hospital of Chengdu, Sichuan, China, between 2021 and 2023. QCT was employed to assess BMD and vertebral rotation. The Cobb angle and Risser sign were determined through radiographic evaluation, while anthropometric and biochemical data were also collected. Statistical analyses, including Pearson and Spearman rank correlation and regression models, were used to investigate the associations between BMD and clinical measures. Results A significant negative correlation was found between BMD and Cobb angle (coefficient =−0.663; P<0.001), as well as between BMD and vertebral rotation angle (coefficient =−0.442; P<0.001) in patients with AIS. BMD was positively correlated with increased height (coefficient =0.355; P<0.001) and BMI (coefficient =0.199; P=0.02). A significant association was detected between BMD and the Risser sign (P=0.002). No significant sex-based differences in BMD were observed (P=0.052). No significant correlations were observed between BMD and levels of potassium (K), calcium (Ca), inorganic phosphate (P), and iron (Fe) (P>0.05 all). The binary logistic regression analysis identified Cobb angle as a risk factor of lower BMD presence in AIS patients (coefficient =0.072; OR=1.075; P<0.001). Furthermore, the receiver operating characteristic (ROC) analysis of the combined model for predicting low BMD in AIS patients yielded an area under the curve (AUC) value of 0.900, with an optimal threshold determined as 0.398. The sensitivity and specificity were calculated as 0.816 and 0.900, respectively, indicating a robust predictive capacity. Conclusions This study highlights the significant inverse correlation observed between BMD measured by QCT and both Cobb angle and vertebral rotation angle in patients with AIS. Furthermore, a notable variation in BMD was found across different Risser sign categories, with BMD values generally increasing as Risser sign levels increased. Additionally, our findings indicate that Cobb angle serves as a risk factor for low BMD presence. Moreover, a combined model was developed to...

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Association Among Complete Blood Count Parameters, Bone Mineral Density, and Cobb Angle in Cases of Adolescent Idiopathic Scoliosis

Cited by 2 publications

References 59 publications

Pubertal Stage-Dependent Anthropometric Variations in Turkish Children with Adolescent Idiopathic Scoliosis: An In-Depth Analysis

Pubertal Stage-Dependent Anthropometric Variations in Turkish Children with Adolescent Idiopathic Scoliosis: An In-Depth Analysis

Quantitative computed tomography assessment of bone mineral density in adolescent idiopathic scoliosis: correlations with Cobb angle, vertebral rotation, and Risser sign

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