Association among ACE, ESR1 polymorphisms and preeclampsia in Brazilian pregnant women

Lopes, Ana Cristina dos Santos; Perucci, Luíza Oliveira; Evangelista, Fernanda Cristina Gontijo; Godói, Lara Carvalho; Sabino, Adriano de Paula; Gomes, Karina Braga; Talvani, André; Dusse, Luci Maria Sant’Ana; Alpoim, Patrícia Nessralla

doi:10.1016/j.mcp.2019.04.004

Cited by 10 publications

(13 citation statements)

References 39 publications

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“…A total of 30 articles 15–44 were included in this study, among which 10 studies were conducted in the Asian population, 19 in the Caucasian population and 1 in the African population. The results showed that polymorphism of ACE I/D gene was associated with Pre‐eclampsia susceptibility, and allele D and genotype DD increased the risk of Pre‐eclampsia in pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Meta‐analysis of angiotensin‐converting enzyme insersion/delection polymorphism and pre‐eclampsia susceptibility

Liu

2020

J of Obstet and Gynaecol

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Aim In recent years, there were many studies on angiotensin‐converting enzyme insersion/delection (ACE I/D) polymorphism and pre‐eclampsia susceptibility, but the conclusion was still inconclusive. Our study is to explore the relationship between the ACE I/D polymorphism and the risk of pre‐eclampsia. Methods The literature on the relationship between ACE I/D gene polymorphism and Pre‐eclampsia susceptibility was obtained by searching the databases of Wanfang, VIP, Medline, CNKI, Embase, Pubmed and Springerlink, which was published from the establishment of the databases to October 2019. Taking the odds ratio (OR) value and its 95% confidence interval (CI) as the effect size, the Meta‐analysis was carried out by using stata 15.0 software. Results Thirty articles, consisting of 3184 patients and 3912 controls, were included. The results showed that allele D was compared with allele I, with the OR value of 1.29 (95% CI: 1.12 ~ 1.50, P < 0.05). Subgroup analysis showed that in Caucasians, allele D was associated with OR of 1.28 (95% CI: 1.08 ~ 1.53, P < 0.05). There was no significant difference in Asians. There was statistical significance in recessive gene model and homozygous gene model, as well as in that of Asian and Caucasian. In homozygous model, there was statistical significance, but subgroup analysis showed there was no statistical significance in Asian and Caucasian. There was no statistical significance in dominant model and heterozygous model. Conclusion The polymorphism of ACE I/D gene was associated with the risk of pre‐eclampsia. Allele D and genotype DD may increase the risk of Pre‐eclampsia in pregnant women.

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Section: Discussionmentioning

confidence: 99%

Meta‐analysis of angiotensin‐converting enzyme insersion/delection polymorphism and pre‐eclampsia susceptibility

Liu

2020

J of Obstet and Gynaecol

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“…10 An array of reactions take place in RAS, through which renin catalyzes AGT and converts it to ANG I, which can be further processed by ACE into ANG II, and ANG II interacts with either AT1R or AT2R to become involved in vasoconstriction, sympathetic activity, cell viability, and aldosterone release. 14,15 Among them, ANG I and II levels depend on renin and ACE activity to a large extent. In addition, ANG I itself is less active and has a weak ability to constrict blood vessels and regulate blood pressure, and its regulation of blood pressure is mainly achieved through conversion to ANG II.…”

Section: Genetic Polymorphisms In Rasmentioning

confidence: 99%

The genetic risk factors for pregnancy‐induced hypertension: Evidence from genetic polymorphisms

et al. 2022

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Pregnancy‐induced hypertension (PIH) is a multifactorial and severe pregnancy complication including preeclampsia/eclampsia, gestational hypertension, chronic (pre‐existing) hypertension, and preeclampsia/eclampsia variants superimposed on chronic hypertension. PIH‐induced maternal mortality accounts for approximately 9% of all maternal deaths over the world. A large number of case‐control studies have established the importance of various genetic factors in the occurrence and development of PIH. In this narrative review, we summarized the genetic risk factors involved in the renin‐angiotensin system, endothelin system, inflammatory factors, oxidative stress, and other functional networks, with the aim of sorting out the genetic factors that may play a potential role in PIH and providing new ideas to elucidate the pathogenesis of PIH.

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“…PE is a primary cause of fetal and maternal morbidity, since it occurs in about 10% of pregnancies (33,34). Depending on blood pressure levels, PE can be classified as mild or severe and by the onset-time of clinical symptoms as early (<34 weeks) or late (≥34 weeks) (35). Early PE includes abnormal placentation and maternal complications, while late PE is often milder and is related to pre-existing conditions of the mother's health, like diabetes mellitus (35).…”

Section: The Ace I/d Polymorphism In Pre-eclampsiamentioning

confidence: 99%

“…Depending on blood pressure levels, PE can be classified as mild or severe and by the onset-time of clinical symptoms as early (<34 weeks) or late (≥34 weeks) (35). Early PE includes abnormal placentation and maternal complications, while late PE is often milder and is related to pre-existing conditions of the mother's health, like diabetes mellitus (35). Having experienced PE, mothers are in a greater risk of developing cardiovascular and renal diseases or diabetes during later stages of life, with the same risk level applying to the newborns, too (32).…”

Section: The Ace I/d Polymorphism In Pre-eclampsiamentioning

confidence: 99%

“…Other factors that might contribute to PE pathogenesis, when coupled with the I/D polymorphism, are body mass index (BMI) and oxidative damage (36). In contrast, two other studies have failed to show the combined effect of ACE I/D with polymorphisms in G protein subunit Beta 3 (GNB3) and estrogen receptor 1 (ESR1) genes in the occurrence of PE (35,39).…”

Section: The Ace I/d Polymorphism In Pre-eclampsiamentioning

confidence: 99%

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The Angiotensin-converting Enzyme Insertion/Deletion Polymorphism as a Common Risk Factor for Major Pregnancy Complications

Gintoni

Αδαμοπούλου

Yapijakis

2021

In Vivo

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Association among ACE, ESR1 polymorphisms and preeclampsia in Brazilian pregnant women

Cited by 10 publications

References 39 publications

Meta‐analysis of angiotensin‐converting enzyme insersion/delection polymorphism and pre‐eclampsia susceptibility

Meta‐analysis of angiotensin‐converting enzyme insersion/delection polymorphism and pre‐eclampsia susceptibility

The genetic risk factors for pregnancy‐induced hypertension: Evidence from genetic polymorphisms

The Angiotensin-converting Enzyme Insertion/Deletion Polymorphism as a Common Risk Factor for Major Pregnancy Complications

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