Associated risk factors for urinary tract infection among pregnant women at Puskesmas Kenangan, Deli Serdang district

Laily, F; Lutan, Delfi; Amelia, Sri; Tala, M; Nasution, Tetty Aman

doi:10.1088/1755-1315/125/1/012035

Cited by 8 publications

(9 citation statements)

References 6 publications

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“…Other factors; gestational age, maternal age, marital status, gravidity, frequency of coitus, direction of cleaning of genitalia, and occupation were not signi cantly associated with the prevalence of symptomatic UTI in pregnant women in our study. This was in agreement with studies conducted in Ethiopia, Sudan (22), and Tanzania, but it was not in agreement with a study conducted in Kenya and Nigeria, where the gestational age was signi cantly associated with the prevalence of UTI in pregnant women. A systematic review by Guido Schmiemann 2010 also found a history of UTI and living with a chronic medical condition (diabetes) to be signi cantly associated UTI in pregnancy (1)…”

Section: Discussionsupporting

confidence: 69%

Prevalence and Bacteriology of Symptomatic Urinary Tract Infection among Pregnant women at Mbarara Regional Referral Hospital, South-western Uganda

Johnson

Stephen

Ngonzi

et al. 2020

Preprint

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Background: Urinary tract infections (UTIs) in pregnant women contribute about 25% of all infections and are among the most frequent clinical bacterial infections. Pregnancy changes in women that include anatomical, physiological and hormonal make them susceptible to develop UTI. Left untreated, UTI in pregnancy is associated with grave complications to the mother and fetus. These complications can be decreased by prompt and proper diagnosis and appropriate treatment that also reduces the emergency of drug resistance. Antimicrobial resistance is a major health problem in the treatment of UTI. We determined the prevalence, bacteriology and antimicrobial susceptibility of symptomatic urinary tract infection among pregnant women at Mbarara Regional Referral Hospital.Methods: We conducted a cross-sectional study from November 2019 to February 2020 involving 400 pregnant women with symptomatic UTI. Patient information was obtained using a structured questionnaire. We collected clean-catch midstream urine specimens for culture and performed antimicrobial susceptibility testing following Clinical and Laboratory Standards Institute standards. Data was entered into RED-cap Version 8.2 software and then exported to Stata Version 14.1 for analysis.Results: The proportion of culture-positive UTI was 140/400 (35%). Gram-negative bacteria were more prevalent (73%): Klebsiella pneumoniae 52(37.41%), Escherichia coli 40(28.78%), Pseudomonas aeruginosa and Proteus mirabilis 7(5.04% each), Citrobacter freundii 1(1%). Staphylococcus aureus 33(23.57%) was the only gram-positive isolate. All the isolates were resistant to ampicillin, amoxicillin, amoxicillin/clavulanic acid and ceftazidime/clavulanic acid (95.7%, 95.0%, 72.9% and 50.7% respectively). Prevalence of extended-spectrum beta-lactamases producing Enterobacteriaceae was 29.0% while that of methicillin-resistant Staphylococcus aureus was 33.3%. Multi-drug resistance (resistance in >2 drugs) was seen in 100% of the isolated bacteria. Majority of the bacterial isolates were sensitive to ciprofloxacin, ceftriaxone, nitrofurantoin, cefotaxime and gentamicin at 82.9%, 81.4%, 79.3%, 78.6%, 66.4% and 65.7% respectivelyConclusions: Klebsiella pneumoniae was the most prevalent isolate followed by E. coli. These two organisms were highly resistant to the commonly used antibiotics. Our study recorded a higher prevalence of culture-positive UTI in pregnancy than all the studies in Uganda. Empirical treatment of UTI should be minimized as sensitivity varies for each organism, for each drug and over time.

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Section: Discussionsupporting

confidence: 69%

Prevalence and Bacteriology of Symptomatic Urinary Tract Infection among Pregnant women at Mbarara Regional Referral Hospital, South-western Uganda

Johnson

Stephen

Ngonzi

et al. 2020

Preprint

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“…Previous diagnosis of UTI was also reported by Behailu Derese et al 2016 in Eastern Ethiopia to be significantly associated with UTI in pregnancy. This might be due to the presence of resistance strains from those who had the previous history of UTI [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and bacteriology of culture-positive urinary tract infection among pregnant women with suspected urinary tract infection at Mbarara regional referral hospital, South-Western Uganda

Johnson

Stephen

Ngonzi

et al. 2021

BMC Pregnancy Childbirth

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Background Urinary tract infections (UTIs) in pregnant women contribute about 25% of all infections and are among the most frequent clinical bacterial infections. Pregnancy changes in women that include anatomical, physiological and hormonal make them susceptible to develop UTI. Left untreated, UTI in pregnancy is associated with grave complications to the mother and fetus. These complications can be decreased by prompt and proper diagnosis and appropriate treatment that also reduces the emergency of drug resistance. Antimicrobial resistance is a major health problem in the treatment of UTI. We determined the prevalence, bacteriology and antimicrobial susceptibility of symptomatic urinary tract infection among pregnant women at Mbarara Regional Referral Hospital. Methods We conducted a cross-sectional study from November 2019 to February 2020 involving 400 pregnant women with symptomatic UTI. Patient information was obtained using a structured questionnaire. We collected clean-catch midstream urine specimens for culture and performed antimicrobial susceptibility testing following Clinical and Laboratory Standards Institute standards. Data was entered into RED-cap Version 8.2 software and then exported to Stata Version 14.1 for analysis. Results The proportion of culture-positive UTI was 140/400 (35%). Gram-negative bacteria were more prevalent (73%): Klebsiella pneumoniae 52(37.41%), Escherichia coli 40(28.78%), Pseudomonas aeruginosa and Proteus mirabilis 7(5.04% each), Citrobacter freundii 1(1%). Staphylococcus aureus 33(23.57%) was the only gram-positive isolate. All the isolates were resistant to ampicillin, amoxicillin, amoxicillin/clavulanic acid and ceftazidime/clavulanic acid (95.7, 95.0, 72.9 and 50.7% respectively). Prevalence of extended-spectrum beta-lactamases producing Enterobacteriaceae was 29.0% while that of methicillin-resistant Staphylococcus aureus was 33.3%. All cultures demonstrated resistance to more than one drug. Majority of the bacterial isolates were sensitive to ciprofloxacin, ceftriaxone, nitrofurantoin, cefotaxime and gentamicin at 82.9, 81.4, 79.3, 78.6, 66.4 and 65.7% respectively. Conclusions Klebsiella pneumoniae was the most prevalent isolate followed by E. coli. These two organisms were highly resistant to the commonly used antibiotics. Our study recorded a higher prevalence of culture-positive UTI in pregnancy than all the studies in Uganda. Empirical treatment of UTI should be minimized as sensitivity varies for each organism, for each drug and over time.

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“…This could be due to the relation of low socioeconomic status with nutrition and immunity especially in pregnant women. In contrast studies were done in Jigjiga, Ethiopia, Medan, Indonesia, and Northeastern Ethiopia 33,45,59 .…”

Section: Variablesmentioning

confidence: 99%

“…The non-formal education was agreed with study done in Goba and Sinana Woredas, Bale Zone, Southeast Ethiopia [AOR = 6.617; CI = 1.87-9.94] 36 . in contract with low level education the studies done in Medan, Indonesia, and Uyo, Nigeria 48,59 . Low-income status was another factor that was related with high prevalence of UTI among pregnant women.…”

Section: Variablesmentioning

confidence: 99%

Prevalence and Antimicrobial Susceptibility Pattern of Urinary Tract Infection among Pregnant Women Attending Hargeisa Group Hospital, Hargeisa, Somaliland

Ali

Reda

Ormago

2021

Preprint

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The aim of this study was to determine the prevalence, antimicrobial susceptibility pattern and associated factors of urinary tract infection (UTI) among pregnant women attending Hargeisa Group Hospital (HGH), Hargeisa, Somaliland. A cross-sectional study was conducted at HGH, Hargeisa, Somaliland and participants were selected by systematic random sampling technique. Clean catch midstream urine samples were collected from 422 participants and cultured and antimicrobial susceptibility pattern was determined for the isolates. Univariable and multivariable logistic regression analyses were utilized to identify the independent risk factors for UTI The prevalence of UTI was 16.4 % (95% CI: 13.3–19.9). The predominant bacteria isolate was E. coli (43.5%). Gram negative bacteria were resistant to ampicillin (96%) and tetracycline (71.4%) and Gram-positive bacteria were also resistant to ampicillin (90%), tetracycline (55%). Multidrug resistance was observed in 89.9% of bacterial isolated. No formal education participants were 3.18 times, previous history of catheterization had 3.22 times and previous history of UTI had 3.73 times more likely to develop UTI than their counterparts respectively. Culture and susceptibility test is vital for appropriate management of UTI in the study area.

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Associated risk factors for urinary tract infection among pregnant women at Puskesmas Kenangan, Deli Serdang district

Cited by 8 publications

References 6 publications

Prevalence and Bacteriology of Symptomatic Urinary Tract Infection among Pregnant women at Mbarara Regional Referral Hospital, South-western Uganda

Prevalence and Bacteriology of Symptomatic Urinary Tract Infection among Pregnant women at Mbarara Regional Referral Hospital, South-western Uganda

Prevalence and bacteriology of culture-positive urinary tract infection among pregnant women with suspected urinary tract infection at Mbarara regional referral hospital, South-Western Uganda

Prevalence and Antimicrobial Susceptibility Pattern of Urinary Tract Infection among Pregnant Women Attending Hargeisa Group Hospital, Hargeisa, Somaliland

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