Associated Leukocyte Responses in the Lethal Aspects of E. coli Shock

Hinshaw, Lerner B.; Beller, B. K.; Archer, L. T.; White, G L

doi:10.3181/00379727-155-39769

Cited by 4 publications

(2 citation statements)

References 1 publication

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“…(1) Live bacteria were introduced by continuous, relatively low-dose intravenous infusion (~ 107 organisms/kg/min) as opposed to a larger, more rapid bolus of organisms (~ 1010/kg) or toxin [11,12,17,18]. As the rate of fall of CO was proportional to the rate of infusion of GBS organisms (cf.…”

Section: Discussionmentioning

confidence: 99%

Nonhomogeneous Redistribution of Mesenteric Blood Flow after Tolazoline during Group B Streptococcal Sepsis in Piglets

Meadow¹,

Meus²

1985

Dev Pharmacol Ther

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The effect of tolazoline (Tz) on mesenteric blood flow was evaluated in a piglet model of group B streptococcal (GBS) sepsis. GBS infusion decreased cardiac output and mesenteric blood flow equivalently, while increasing systemic and mesenteric vascular resistance. At three doses between 2 and 25 mg/kg, Tz increased cardiac output and decreased systemic vascular resistance. However, at no dose did Tz improve the diminished mesenteric artery blood flow which accompanied GBS sepsis. The potential use of Tz in neonatal sepsis may be limited by its nonhomogeneous redistribution of blood flow.

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Section: Discussionmentioning

confidence: 99%

Nonhomogeneous Redistribution of Mesenteric Blood Flow after Tolazoline during Group B Streptococcal Sepsis in Piglets

Meadow¹,

Meus²

1985

Dev Pharmacol Ther

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“…24,[37][38][39][40][41][42][82][83][84][85][86] Hepatic lesions appear concomitantly during the development of hypoglycemia. [88][89][90][91] Glucose utilization is accelerated during the progression of endotoxin shock, [91][92][93] and glycogen stores are rapidly depleted. [94][95][96][97] The net effect of these actions is an imbalance between the formation of glucose and the demand for it as a fuel, and hypoglycemia results.…”

Section: Metabolic-endocrinologic Actionsmentioning

confidence: 99%