Associated factors with psychological distress in Moroccan breast cancer patients: A cross-sectional study

Berhili, Soufiane; Kadiri, Selma El; Bouziane, Amal; Aissa, Abdallah; Marnouche, El Amin; Ogandaga, Etienne; Echchikhi, Yassine; Touil, Asmae; Loughlimi, Hasna; Lahdiri, I.; Majjaoui, Sanae El; Kacemi, H. El; Kebdani, Tayeb; Benjaafar, Noureddine

doi:10.1016/j.breast.2016.10.015

Cited by 50 publications

(44 citation statements)

References 65 publications

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“…In another paper studying 2776 patients with cancer visiting a tertiary cancer center in Canada, significant gender differences were found; female patients reported depressive symptoms more frequently than male patients and were more likely to receive psychosocial support [19]. Contrary to our results, they also found younger patients to be at a higher risk of PD [19], as did a recent study among breast cancer patients in Morocco [25]. This might be related to the study populations, namely patients with all stages of cancer, where the disruption of social life might be different compared to patients in the palliative phase.…”

Section: Discussioncontrasting

confidence: 99%

“…It is therefore important to identify patients with high levels of PD early, to increase awareness of both patients and health care professionals on this topic and if wanted, to offer interventions. Most of the current literature on PD was acquired in patients with cancer treated with a curative intent [19,[24][25][26][27][28]. To our knowledge, no studies were performed so far specifically in patients with bone metastases.…”

Section: Introductionmentioning

confidence: 99%

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Screening for psychological distress before radiotherapy for painful bone metastases may be useful to identify patients with high levels of distress

et al. 2017

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Background: Psychological distress (PD) has a major impact on quality of life. We studied the incidence of PD before and after radiotherapy for painful bone metastases. Furthermore, we aimed to identify factors predictive for PD. Methods: Between 1996 and 1998, the Dutch Bone Metastasis Study included 1157 patients with painful bone metastases. Patients were randomized between two fractionation schedules. The study showed a pain response of 74% in both groups. Patients filled out weekly questionnaires for 13 weeks, then monthly for two years. The questionnaires included a subscale for PD on the Rotterdam Symptom Checklist. We used generalized estimating equations and multivariable logistic regression analyses. Results: At baseline, 290 patients (27%) had a high level of PD. For the entire group, the level of PD remained constant over time. The majority of patients with a low level of PD at baseline remained at a low level during follow-up. In patients with a high level of PD at baseline, the mean level of PD decreased after treatment and stabilized around the cutoff level. Female patients, higher age, worse performance, lower pain score and worse self-reported QoL were associated with an increased chance of PD, although the model showed moderate discriminative power. Conclusions: A substantial proportion of patients had a high level of PD before and after radiotherapy for painful bone metastases. Most patients who reported high levels of PD when referred for palliative radiotherapy remained at high levels thereafter. Therefore, screening of PD prior to treatment seems appropriate, in order to select patients requiring intervention.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Screening for psychological distress before radiotherapy for painful bone metastases may be useful to identify patients with high levels of distress

et al. 2017

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“…All these factors seem to be interrelated as patients with metastasis have many physical and psychosocial problems associated with the disease, its progression, and treatment that compromises their QOL [42]. In particular, patients with metastasis express more pain, anxiety, and depression [43,44] and many studies have suggested a bidirectional relationship between anxiety/depression and insomnia [45,46]. Moreover, insomnia is a major public health issue affecting the QOL of a large number of people all over the world with deleterious consequences such as long-term physical and mental exhaustion with altered mood, concentration, and memory.…”

Section: Discussionmentioning

confidence: 99%

“…These results are accurate, as with age, the economic impact on the disease is less important than in younger patients and consequently, the financial difficulties are less pronounced. In addition, the impact of cancer, especially in end-of-life settings, on the social role of patients would be more problematic when the patient is young because of the increased prevalence of depression and anxiety [43]. …”

Section: Discussionmentioning

confidence: 99%

OPRM1 c.118A>G Polymorphism and Duration of Morphine Treatment Associated with Morphine Doses and Quality-of-Life in Palliative Cancer Pain Settings

Hajj

Halepian

Osta

et al. 2017

IJMS

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Despite increased attention on assessment and management, pain remains the most persistent symptom in patients with cancer, in particular in end-of-life settings, with detrimental impact on their quality-of-life (QOL). We conducted this study to evaluate the added value of determining some genetic and non-genetic factors to optimize cancer pain treatment. Eighty-nine patients were included in the study for the evaluation of palliative cancer pain management. The regression analysis showed that age, OPRM1 single nucleotide polymorphism (SNP), as well as the duration of morphine treatment were significantly associated with morphine doses at 24 h (given by infusion pump; p = 0.043, 0.029, and <0.001, respectively). The mean doses of morphine decreased with age but increased with the duration of morphine treatment. In addition, patients with AG genotype c.118A>G OPRM1 needed a higher dose of morphine than AA patients. Moreover, metastases, OPRM1 SNP, age, and gender were significantly associated with the QOL in our population. In particular, AA patients for OPRM1 SNP had significantly lower cognitive function than AG patients, a result not previously reported in the literature. These findings could help increase the effectiveness of morphine treatment and enhance the QOL of patients in regards to personalized medicine.

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“…It can be generated by genetic, epigenetic, nutritional, environmental and physiological perturbations [75][76][77]. Cancer presents several pathologies that are distinguished from one to another according to the cellular tropism.…”

Section: Anticancer Propertiesmentioning

confidence: 99%

Pharmacological activities and medicinal properties of endemic Moroccan medicinal plant Origanum compactum (Benth) and their main compounds

Bouyahya¹,

Guaouguaou²,

Dakka³

et al. 2017

APJTD

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Associated factors with psychological distress in Moroccan breast cancer patients: A cross-sectional study

Cited by 50 publications

References 65 publications

Screening for psychological distress before radiotherapy for painful bone metastases may be useful to identify patients with high levels of distress

Screening for psychological distress before radiotherapy for painful bone metastases may be useful to identify patients with high levels of distress

OPRM1 c.118A>G Polymorphism and Duration of Morphine Treatment Associated with Morphine Doses and Quality-of-Life in Palliative Cancer Pain Settings

Pharmacological activities and medicinal properties of endemic Moroccan medicinal plant Origanum compactum (Benth) and their main compounds

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