Associated Factors for Mortality in a COVID-19 Colombian Cohort by Epidemic Wave: Is the Predominance of Mu Variant Relevant?

Álvarez-Moreno, Carlos; Valderrama-Beltrán, Sandra; Silva, Ronaldo; Siegler, Ilich Herbert De La Hoz; Vega, Fabio Andrés Varón; Martínez-Vernaza, Samuel; Blanco, Tatiana Ordoñez-; Padilla, Mónica; Mesa-Rubio, María Lucía; Pascagaza, Laura Carmenza Castañeda; Rojas, José Antonio; Ojeda, Juan Sebastián Bravo; Villa, Jaime; Sarmiento, Julio Alberto Chacón; Yomayusa, Nancy; Patiño, S.; Gómez-Nieto, Katherine; Pinzón, Viviana Lorena Martínez; Cogollo, Angélica María Ramírez; Toloza, Carlos; Díaz, Melissa; Cañas-Arboleda, Alejandra; Manrique-Andrade, Margarita; Ayub, Roberto Tarud; Mora, María José López; Espinosa, María Julieta Pachón; Cortés, Jorge Alberto; Sánchez, Laura Catalina; Acevedo, Kelly; Rengifo, Paola; Tambini, Ginna; Bertagnolio, Silvia; Dı́az, Janet; Thwin, Soe Soe; Revéiz, Ludovic

doi:10.2139/ssrn.4330287

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“…During this same period, we observed a decline in mortality rates in Colombia and Argentina, aligning with previous findings reported by Calonico and Álvarez [27,28]. This decrease is likely attributed to a better understanding of the disease as well as increased adherence to global evidence-based guidelines [27]. This observation highlights the importance of monitoring and studying the impact of different variants on healthcare systems and the importance of ongoing research into the dynamics of SARS-CoV-2 variants and their impacts on public health.…”

Section: Discussionsupporting

confidence: 90%

Severe COVID-19 Outcomes in Five Latin American Countries in the Postvaccination Era

Silva Julian,

Spinardi,

Diaz-Puentes

et al. 2024

Viruses

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We conducted a multicountry retrospective study using data from COVID-19 national surveillance databases to analyze clinical profiles, hospitalization rates, intensive care unit (ICU) admissions, utilization of ventilatory support, and mortality rates in five Latin American countries in the context of COVID-19 vaccination implementation. We analyzed the sociodemographic characteristics, comorbidities, clinical outcomes, and vaccination status of laboratory-confirmed COVID-19 cases from January 2021 to December 2022. We calculated the yearly and quarterly hospitalization rates per 1000 confirmed COVID-19 cases and ICU admissions, use of mechanical ventilators, and mortality rates per 1000 hospitalized cases, with their corresponding 95% confidence interval (CI) of 38,852,831 confirmed COVID-19 cases. Rates of hospitalization, ICU admission, ventilatory support, and death were higher among males than among females (38.2 vs. 32.4, 148.4 vs. 117.7, 282.9 vs. 236.2, and 346.9 vs. 320.1 per 1000, respectively); higher in 2021 than in 2022 (50.7 vs. 19.9, 207.8 vs. 58.2, 441.5 vs. 114.9, and 352.5 vs. 285.2 per 1000, respectively); and in the >50 age group (range: 5.7–18.6, 20.1–71.5, 12.2–67.9, and 353.1–577.4, per 1000) than the <50 age group (range: 2.2–9.3, 5.4–33.2, 41.4–135.8, and 22–243.5 per 1000). Hypertension and diabetes mellitus were the most common comorbidities in Mexico and Colombia. Prevention and treatment strategies for these case profiles could bring benefits from a public health perspective.

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Section: Discussionsupporting

confidence: 90%