Associated factors for acute kidney injury in preterm infants

Abstract

Objective: to analyze the prevalence and factors associated with acute kidney injury in preterm newborns. Method: a cross-sectional study based on records data of preterm newborns hospitalized in two neonatal units in northwest Paraná State in 2015. For data analysis, the logistic regression model was used by the stepwise forward method and Fisher's Exact Test. Results: 132 preterm newborns, with a prevalence of 7.5% of acute kidney injury, were hospitalized. Majority of males, extremely preterm and very low birth weight. Associated factors were the use of non-nephrotoxic antibiotics and the presence of mechanical pulmonary ventilation, increasing the chance of developing acute kidney damage by 2.98 and 1.33/day, respectively. Hospitalization days constituted a protection factor. Conclusion: this study was able to identify the prevalence, and outline the variables associated with acute kidney injury in preterm newborns in a particular care situation. RESUMOObjetivo: analisar a prevalência e fatores associados à lesão renal aguda em recém-nascidos prematuros. Método: estudo transversal realizado a partir de dados de prontuários de recémnascidos prematuros internados em duas unidades neonatais do noroeste paranaense em 2015. Para análise dos dados, utilizou-se o modelo de regressão logística pelo método stepwise forward e Teste Exato de Fisher. Resultados: foram internados 132 prematuros, com prevalência de 7,5% de lesão renal aguda. Maioria do sexo masculino, prematuros extremos e com muito baixo peso ao nascer. Os fatores associados foram o uso de antibióticos não nefrotóxicos e a presença de ventilação pulmonar mecânica, aumentando em 2,98 e 1,33/dia a chance do desenvolvimento de lesão renal aguda, respectivamente. Os dias de hospitalização constituíram fator de proteção. Conclusão: este estudo foi capaz de identificar a prevalência e delinear as variáveis associadas à ocorrência de lesão renal aguda em recém-nascidos prematuros numa determinada realidade assistencial. RESUMENObjetivo: analizar la prevalencia y factores asociados a la lesión renal aguda en recién nacidos prematuros. Método: estudio transversal realizado a partir de datos de prontuarios de recién nacidos prematuros internados en 2 unidades neonatales del noroeste del estado de Paraná en 2015. Para el análisis de los datos, se utilizó el modelo de regresión logística por el método stepwise forward y Test Exacto de Fisher. Resultados: fueron internados 132 prematuros, con prevalencia del 7,5% de lesión renal aguda. La mayoría era del sexo masculino, prematuros extremos y con muy bajo peso al nacer. Los factores asociados fueron el uso de antibióticos no nefrotóxicos y la presencia de ventilación pulmonar mecánica, aumentando en 2,98 y 1,33/día la posibilidad del desarrollo de lesión renal aguda, respectivamente. Los días de hospitalización constituyeron un factor de protección. Conclusión: este estudio fue capaz de identificar la prevalencia y delinear las variables asociadas a la ocurrencia de lesión renal aguda en recién nacidos prematuros en un...

Does Caffeine Citrate Administration Decrease Risk of Acute Kidney Injury in Hospitalized Preterm Neonates?

“…In Felipin et al [13], who observed that the prevalence of AKI was more present in extreme preterm infants, that is, less than 28 weeks of gestational age and in PTNB less than 1500 grams like our study results.…”

Magnitude and associated factors of acute kidney injury among preterm neonates admitted to public hospitals in Bahir Dar city, Ethiopia 2022: cross-sectional study

“…This could be due to the diagnosis of AKI in that study was defined by SCr greater than 1.5 mg/dl while in this study defined AKI an absolute serum creatinine rise ≥ 0.3 mg/dL or SCr rise ≥ 1.5–1.9 × baseline SCr within 48 h and there was also differences in included study populations. Also, this study finding is higher than studies conducted in northwest Parana state (7.5%), Iran (10.68%), India (12%), and United Arab Emirates (11.6%) [ 22 , 37 – 39 ]. This may probably be due to study setting (institutional level) differences.…”

Clinical profile and outcome of acute kidney injury in preterm neonates in a level three neonatal intensive care unit

“…In a case control study done by Cataldi et al with 81 neonates, it was found that 48% of babies were extreme preterm babies whereas in a retrospective study done by Felipin et al it was found that percentage of extreme preterm babies was 60%. 6,20 In the current study, it was found that 40% of the babies were having birth weight less than 1000grams, 40% of babies were having birth weight between 1000-1500 grams, and 20% were having birth weight between 1500-2500 grams.…”

“…In a retrospective study done by Felipin et al it was found that 60% of the babies were having birth weight of less than 1000 grams, 30% of babies were having birth weight between 1000-1500 grams; 10% of babies were having birth weight between 1500-2500 grams. 20 In this study, it was found that 31% of babies were small for gestational age (SGA). In a study done by Viswananthan et al in 2011, 41% of babies were SGA and in study done by Bolat et al it was found that 33.3% of babies were SGA.…”