Associated deficits in mismatch negativity generation and tone matching in schizophrenia

Javitt, Daniel C.; Shelley, Anne-Marie; Ritter, Walter

doi:10.1016/s1388-2457(00)00377-1

Cited by 232 publications

(142 citation statements)

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“…Sweet et al 49 suggested that the abnormalities observed from postmortem studies may give rise to impaired precision of early auditory processing. 51 Deficits in auditory processing, such as reduced tone matching abilities or abnormalities in electroencephalographic activity during early phases of auditory processing are evident in schizophrenia, and may contribute to mechanisms leading to AH. 9 An alternative explanation for cortical thinning measured by MRI, is cerebral blood flow alterations in relation to hallucination status.…”

Section: Discussionmentioning

confidence: 99%

Auditory Cortex Characteristics in Schizophrenia: Associations With Auditory Hallucinations

Mørch-Johnsen

Nesvåg

Jørgensen

et al. 2016

Schizophrenia Bulletin

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There were no significant differences between AH+ and AH− patients in cortical thickness in the PT or STG, or in auditory cortex surface area in any of the regions investigated. Group differences in cortical thickness in the left HG was not affected by duration of illness or current antipsychotic medication. Conclusions: AH in schizophrenia patients were related to thinner cortex, but not smaller surface area of the left HG, a region which includes the primary auditory cortex. The results support that structural abnormalities of the auditory cortex underlie AH in schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Auditory Cortex Characteristics in Schizophrenia: Associations With Auditory Hallucinations

Mørch-Johnsen

Nesvåg

Jørgensen

et al. 2016

Schizophrenia Bulletin

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“…In subjects with schizophrenia, the rapid initial phases of transfer and processing of sensory information within the auditory cortex are impaired (McCarley et al, 1991;Javitt et al, 1994Javitt et al, , 1995Javitt et al, , 1997bJavitt et al, , 2000Rabinowicz et al, 2000). These impairments are manifest as the reduced ability to discriminate tones Strous et al, 1995;Wexler et al, 1998) and as deficits in recognition of prosody (Leitman et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Reduced Dendritic Spine Density in Auditory Cortex of Subjects with Schizophrenia

Sweet

Henteleff

Zhang

et al. 2008

Neuropsychopharmacol

252

216

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We have previously identified reductions in mean pyramidal cell somal volume in deep layer 3 of BA 41 and 42 and reduced axon terminal density in deep layer 3 of BA 41. In other brain regions demonstrating similar deficits, reduced dendritic spine density has also been identified, leading us to hypothesize that dendritic spine density would also be reduced in BA 41 and 42. Because dendritic spines and their excitatory inputs are regulated in tandem, we further hypothesized that spine density would be correlated with axon terminal density. We used stereologic methods to quantify a marker of dendritic spines, spinophilin-immunoreactive (SP-IR) puncta, in deep layer 3 of BA 41 and 42 of 15 subjects with schizophrenia, each matched to a normal comparison subject. The effect of long-term haloperidol exposure on SP-IR puncta density was evaluated in nonhuman primates. SP-IR puncta density was significantly lower by 27.2% in deep layer 3 of BA 41 in the schizophrenia subjects, and by 22.2% in deep layer 3 of BA 42. In both BA 41 and 42, SP-IR puncta density was correlated with a marker of axon terminal density, but not with pyramidal cell somal volume. SP-IR puncta density did not differ between haloperidol-exposed and control monkeys. Lower SP-IR puncta density in deep layer 3 of BA 41 and 42 of subjects with schizophrenia may reflect concurrent reductions in excitatory afferent input. This may contribute to impairments in auditory sensory processing that are present in subjects with schizophrenia.

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“…Deficits in early auditory sensory processing, including N1, MMN, and P300, have been shown using ERP in schizophrenic subjects (Baldeweg et al, 2004;Kasai et al, 2002;Salisbury et al, 1998;Javitt et al, 2000;Javitt et al, 1995;Elvevag et al, 2004), in prodromal subjects (Brockhaus-Dumke et al, 2005), and in SPD subjects (Salisbury et al, 1996;Niznikiewicz et al, 2000;Liu et al, 2007). Moreover, progressive changes in schizophrenic subjects can be indexed using a MMN paradigm in the ERP environment (Salisbury et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…However, as SPD has demonstrated less severe abnormalities than schizophrenia on electrophysiological measures (Trestman et al, 1996), more extreme differences in terms of pitch and duration between the standard and deviant tones were selected to amplify the fMRI signal. Moreover, a larger differentiation between standard and deviant tones would help to compensate for any potential deficit in tone discrimination processing described in the schizophrenia literature (Javitt et al, 2000;Leitman et al, 2005). Although a lower percentage of deviant tones would have similarly increased an electrophysiological signal (Javitt et al, 2000), in order to achieve enough trials for an adequate hemodynamic response, a higher percentage of deviant tones was selected.…”

Section: Discussionmentioning

confidence: 99%

“…Auditory sensory processing has been found to be impaired in schizophrenia (Salisbury et al, 1998;Javitt et al, 2000) and correlate with clinical features, particularly negative symptoms (Javitt et al, 2000), (Kasai et al, 2002) (Leitman et al, 2005) and cognitive impairment (Baldeweg et al, 2004). Abnormalities in the superior temporal gyrus (STG) have been implicated in the processing of pure tones, a fundamental element of complex sounds and language, using fMRI (Wible et al, 2001) and event-related potentials (Salisbury et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

Dickey

Mórocz

Niznikiewicz

et al. 2008

Schizophrenia Research

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Background-One of the cardinal features of schizotypal personality disorder (SPD) is language abnormalities. The focus of this study was to determine whether or not there are also processing abnormalities of pure tones differing in pitch and duration in SPD.Methods-Thirteen neuroleptic-naïve male subjects met full criteria for SPD and were groupmatched on age and parental socioeconomic status to 13 comparison subjects. Verbal learning was measured with the California Verbal Learning Test. Heschl's gyrus volumes were measured using structural MRI. Whole-brain fMRI activation patterns in an auditory task of listening to tones including pitch and duration deviants were compared between SPD and control subjects. In a Contributors Dickey: designed the study, collected the fMRI data, analyzed the clinical and fMRI data, and wrote the manuscript. Morocz: analyzed the fMRI data. Niznikiewicz: collected and analyzed the ERP data, and contributed to the manuscript. Voglmaier: collected and analyzed CVLT data, and performed SCID interview. Dreusicke: analyzed the fMRI data. Toner: aided in fMRI data collection. Yoo: aided in initial fMRI data collection. Khan: aided in final fMRI data presentation. Shenton: reviewed the manuscript. McCarley: reviewed the manuscript. Conflict of interestAll authors declare that they have no conflict of interest. Results-In the region of the STG, SPD subjects demonstrated more activation to pitch deviants bilaterally (p<0.001); and to duration deviants in the left hemisphere (p=0.005) (two-sample t). SPD subjects also showed more bilateral parietal cortex activation to duration deviants. In no region did comparison subjects activate more than SPD subjects in either experiment. Exploratory correlations for SPD subjects suggest a relationship between peak activation on the right for deviant tones in the pitch experiment with odd speech and impaired verbal learning. There was no difference between groups on Heschl's gyrus volume. NIH Public AccessConclusions-These data suggest that SPD subjects have inefficient or hyper-responsive processing of pure tones both in terms of pitch and duration deviance that is not attributable to smaller Heschl's gyrus volumes. Finally, these auditory processing abnormalities may have significance for the odd speech heard in some SPD subjects and downstream language and verbal learning deficits.

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Associated deficits in mismatch negativity generation and tone matching in schizophrenia

Cited by 232 publications

References 14 publications

Auditory Cortex Characteristics in Schizophrenia: Associations With Auditory Hallucinations

Auditory Cortex Characteristics in Schizophrenia: Associations With Auditory Hallucinations

Reduced Dendritic Spine Density in Auditory Cortex of Subjects with Schizophrenia

Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

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