Associated autoimmunity in Type 1 Diabetes and latent autoimmune diabetes of adults: The role of glutamic-acid decarboxylase autoantibodies

Gougourelas, Dimitrios; Tsentidis, Charalampos; Koufadaki, Athina Maria; Koutsovasilis, Anastasios; Gougourela, Eupraxia; Karanasios, Spyridon; Sotiropoulos, Alexios; Bousboulas, Stavros; Karavanaki, Kyriaki

doi:10.1016/j.diabres.2021.108847

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…During the follow-up of several longitudinal cohorts of T1D patients, GADA titers are shown to be associated with various persistent autoimmunity activity levels and disease development (5,6). Patients who are GADA positive are more likely to have multiple autoimmune diseases, such as Hashimoto's thyroiditis and gastritis (7,8). However, the underlying biological mechanisms of T1D patients with different GADA phenotypes is not completely understood.…”

Section: Introductionmentioning

confidence: 99%

Gut microbiome and metabolic activity in type 1 diabetes: An analysis based on the presence of GADA

Luo

Tong²,

Liu³

et al. 2022

Front. Endocrinol.

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ObjectiveType 1 diabetes (T1D) progression is affected by circulating glutamic acid decarboxylase antibody (GADA) that persist for many years. This study aimed at investigating whether and how the gut microbiome and its correlated metabolites change in T1D with the presence of GADA.MethodsWe used a radiobinding assay to measure GADA titers and identify the 49 T1D patients with GADA+ and 52 T1D patients with GADA-. The fresh feces and serum were analyzed using 16S rRNA gene sequencing and GC/MS. Then gut microbiome and serum metabolites were compared between the GADA+ patients and the GADA- patients. The association between gut microbial community and metabolites was assessed using the Spearman’s rank correlation.ResultsThe gut microbiome in diversity, composition, and function differed between these two groups. The abundance of genus Alistipes, Ruminococcus significantly increased in patients with GADA+ compared to that observed in the samples of GADA-. There were 54 significantly altered serum metabolites associated with tryptophan metabolism, phenylalanine, and tyrosine biosynthesis in individuals with GADA+ compared with those of GADA-For the serum metabolites, compared with those of GADA-, there were 54 significantly different metabolites with tryptophan metabolism, phenylalanine, and tyrosine and tryptophan biosynthesis decreased in individuals with GADA+. The abundance of Alistipes was positively correlated with altered metabolites involved in tryptophan metabolism.ConclusionWe demonstrate that T1D patients with GADA+ are characterised by aberrant profiles of gut microbiota and serum metabolites. The abundance of Alistipes disturbances may participate in the development of T1D patients with GADA by modulating the host’s tryptophan metabolism. These findings extend our insights into the association between the gut microbiota and tryptophan metabolism and GADA and might be targeted for preventing the development of T1D.

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Section: Introductionmentioning

confidence: 99%

Gut microbiome and metabolic activity in type 1 diabetes: An analysis based on the presence of GADA

Luo

Tong²,

Liu³

et al. 2022

Front. Endocrinol.

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Advances in the use of electrospinning as a promising technique for obtaining nanofibers to guide epithelial wound healing in diabetics—Mini‐review

Costa

Menezes

Dias

et al. 2022

Polymers for Advanced Techs

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Diabetes is one of the chronic diseases that most affect the world population, and it is estimated that in a few years it will progressively increase. It can appear at any stage of life, being Type I most common in childhood and Type II in adulthood, but both are related to hyperglycemia. Studies show that physical inactivity, obesity, and poor eating habits can influence the onset and/or worsening of Type II diabetes. Among the complications that diabetics may develop are amputations, these are caused due to the neuropathy that the diabetic develops and ends up losing sensitivity when injured. Consequently, the wounds often become infected ulcers and the tissue dies, leading the patient to undergo surgical procedures for tissue removal. To try to prevent wounds from becoming ulcers and/or to reduce the percentage of amputations, researchers have been using the electro‐spinning technique to form nanofibers. The fibers when electrospun have nanofiber morphology and one of the characteristics of these is the volume/area ratio in which positively increases the properties of the fibers. These are being widely used in tissue engineering as they have been shown to be effective in tissue regeneration. In addition, they prove to be promising in the biomedical area for modified drug release. Polymers such as poly (ε‐caprolactone), poly (lactic‐co‐glycolic acid), gum tragacanth, among others, are gaining ground in the scientific field to produce nanofibers incorporating some antioxidant, antimicrobial, and anti‐inflammatory agent. For treating diabetic wounds, preventing amputation processes and an improvement in the quality of life. The aim of this paper is to review the use of the electrospinning technique to aid the healing of diabetic wounds in the scientific literature.

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The ethyl acetate extract from Abutilon fruticosum Guill and Perr. as a potential diabetes–cancer prophylactic: A cytotoxic, α-glucosidase, and in-silico study

Gouda

Morsy

Youssef

et al. 2023

South African Journal of Botany

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Associated autoimmunity in Type 1 Diabetes and latent autoimmune diabetes of adults: The role of glutamic-acid decarboxylase autoantibodies

Cited by 3 publications

References 42 publications

Gut microbiome and metabolic activity in type 1 diabetes: An analysis based on the presence of GADA

Gut microbiome and metabolic activity in type 1 diabetes: An analysis based on the presence of GADA

Advances in the use of electrospinning as a promising technique for obtaining nanofibers to guide epithelial wound healing in diabetics—Mini‐review

The ethyl acetate extract from Abutilon fruticosum Guill and Perr. as a potential diabetes–cancer prophylactic: A cytotoxic, α-glucosidase, and in-silico study

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