Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM)

Kakleas, Kostas; Soldatou, Alexandra; Karachaliou, Feneli; Karavanaki, Kyriaki

doi:10.1016/j.autrev.2015.05.002

Cited by 108 publications

(105 citation statements)

References 337 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Type 1 diabetes is an autoimmune disease characterized by the complete loss of insulin (INS) due to the destruction of β cells, and its treatment is solely dependent on INS administration1. Although islet transplantation is a promising therapy for type 1 diabetes, difficulties in obtaining sufficient islets and immunosuppression problems point to the need for alternative cell sources for the generation of INS-expressing β cells2.…”

mentioning

confidence: 99%

An inhibitor of fibroblast growth factor receptor-1 (FGFR1) promotes late-stage terminal differentiation from NGN3+ pancreatic endocrine progenitors

Yamashita‐Sugahara

Matsumoto

Ohtaka

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Human induced pluripotent stem cells (hiPSCs) provide a potential resource for regenerative medicine. To identify the signalling pathway(s) contributing to the development of functional β cells, we established a tracing model consisting of dual knock-in hiPSCs (INS-Venus/NGN3-mCherry) (hIveNry) expressing the fluorescent proteins Venus and mCherry under the control of intrinsic insulin (INS) and neurogenin 3 (NGN3) promoters, respectively. hIveNry iPSCs differentiated into NGN3- and mCherry-positive endocrine progenitors and then into Venus-positive β cells expressing INS, PDX1, NKX6.1, and glucokinase (GCK). Using these cells, we conducted high-throughput screening of chemicals and identified a specific kinase inhibitor of fibroblast growth factor receptor 1 (FGFR1) that acted in a stage-dependent manner to promote the terminal differentiation of pancreatic endocrine cells, including β cells, from the intermediate stage of pancreatic endocrine progenitors while blocking the early development of pancreatic progenitors. This FGFR1 inhibitor augmented the expression of functional β cell markers (SLC30A8 and ABCC8) and improved glucose-stimulated INS secretion. Our findings indicate that the hIveNry model could provide further insights into the mechanisms of hiPS-derived β cell differentiation controlled by FGFR1-mediated regulatory pathways in a temporal-dependent fashion.

show abstract

mentioning

confidence: 99%

An inhibitor of fibroblast growth factor receptor-1 (FGFR1) promotes late-stage terminal differentiation from NGN3+ pancreatic endocrine progenitors

Yamashita‐Sugahara

Matsumoto

Ohtaka

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…APS is distinguished by age of presentation, characteristic patterns of disease combinations and different modes of inheritance. Based on clinical criteria, in 1980, Neufeld and Blizzard published a classification of the APS describing four main types 15. APS 1, most commonly characterised by mucocutaneous candidiasis, hypoparathyroidism and primary adrenal insufficiency, is an autosomal recessive disorder caused by mutations in the AIRE gene (autoimmune regulator gene) found on chromosome 21 14 16 17.…”

Section: Discussionmentioning

confidence: 99%

“…Examples of associated ADs include type 1 diabetes mellitus, pernicious anaemia, coeliac disease, atrophic gastritis and vitiligo 15. Women are more often affected than men.…”

Section: Discussionmentioning

confidence: 99%

Unusual case of anti-N-methyl-D-aspartic acid-receptor (NMDA-R) encephalitis and autoimmune polyglandular syndrome (APS)

Frunza-Stefan¹,

Whitlatch

Rao

et al. 2018

BMJ Case Reports

View full text Add to dashboard Cite

Anti-N-methyl-D-aspartic acid-receptor (NMDA-R) encephalitis is a novel disease discovered within the past 10 years. It is an autoimmune disease (AD) that has been associated with other ADs, such as Graves' disease. However, association with autoimmune polyglandular syndromes (APS) has not been previously described. A 58-year-old woman presented with altered mental status and an 8-month history of weight loss, apathy and somnolence. Laboratory evaluation confirmed Graves' disease with thyrotoxicosis and type 1 diabetes mellitus. Despite treatment, she continued to have a fluctuating mental status. Further diagnostic evaluation included an abdominal MRI that showed a cystic lobular left adnexal mass. Serum anti-NMDA-R antibodies were positive, raising concern for NMDA-R encephalitis. Bilateral salpingo-oophorectomy was performed, with pathology consistent with cystadenofibroma. She had a favourable recovery with marked clinical improvement. Anti-NMDA-R antibodies were negative 2 months following surgery. The concomitant occurrence of APS and anti-NMDA-R encephalitis suggests a shared mechanism of autoimmune pathophysiology.

show abstract

“…Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disorder caused by destruction of beta cells of the pancreas lead to the clinical form of the disease and is associated with autoantibodies targeting components of insulin-producing cells: Anti-islet cell (ICA), anti-glutamic acid decarboxylase (anti-GAD), anti-tyrosine phosphatase (anti-IA2), and anti-zinc transporter 8 protein (ZnT8) 2 .However the prevalence in Saudi Arabia is higher in compare to other communities that may due to the majority of the patients being unaware of their disease, which warrants urgent adoption of early detection, treatment and prevention programs 3 . Patients with T1DM are at high risk of developing other autoimmune diseases, such as autoimmune thyroiditis (AIT), celiac disease, Addison's disease, vitiligo, celiac disease, autoimmune hepatitis, myasthenia gravis, and pernicious anemia 4,5 . Autoimmune thyroiditis (AIT) is the most common autoimmune disease associated with type 1 diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

Thyroid Peroxidase Autoantibodies and Thyroid Hormones in Children with Type1 Diabetes Mellitus in Najran Area, Saudi Arabia

2017

JCBSC

View full text Add to dashboard Cite

Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM)

Cited by 108 publications

References 337 publications

An inhibitor of fibroblast growth factor receptor-1 (FGFR1) promotes late-stage terminal differentiation from NGN3+ pancreatic endocrine progenitors

An inhibitor of fibroblast growth factor receptor-1 (FGFR1) promotes late-stage terminal differentiation from NGN3+ pancreatic endocrine progenitors

Unusual case of anti-N-methyl-D-aspartic acid-receptor (NMDA-R) encephalitis and autoimmune polyglandular syndrome (APS)

Thyroid Peroxidase Autoantibodies and Thyroid Hormones in Children with Type1 Diabetes Mellitus in Najran Area, Saudi Arabia

Contact Info

Product

Resources

About