Associação entre cultura de secreção vaginal, características sociodemográficas e manifestações clínicas de pacientes com diagnóstico de candidíase vulvovaginal

Rodrigues, Márcio Tavares; Gonçalves, Ana C.; Alvim, Mariana Carolina Tocantins; Filho, Didier Silveira Castellano; Zimmermmann, Juliana Barroso; Silva, Vânia Lúcia da; Diniz, Cláudio Galuppo

doi:10.1590/s0100-72032013001200005

Cited by 14 publications

(14 citation statements)

References 22 publications

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“…However, this difference in age between the group of women with VVC and the otherwise healthy group was not detected by other authors 1, 17, 19, 23. Similarly, use of hormonal contraception or intrauterine devices, vaginal pH ≤ 4.5, pregnancy and HIV infection, which are considered as risk factors for the development of VVC3, 5, 20, 26 were not significantly associated with VVC infection in our study.…”

Section: Discussioncontrasting

confidence: 77%

“…According to our study as well as that of Rodrigues and co-workers 23 the other variables such as marital status, educational level and skin color do not exert significant influence on the development of VVC. Moreover, Álvares and co-workers 4 state that the vaginal microbiota of black women has a lower incidence of bacterial species, and there would thus be a decrease in natural defenses against fungal growth, predisposing them to infection by Candida spp 4, 20…”

Section: Discussionsupporting

confidence: 57%

“…Among these, C. glabrata , described as the second most important species in cases of VVC due to its frequency10, 12, 15, 18, 23 and greater resistance to antifungals10, 22, 24 was found in 8.6% of symptomatic patients and in 14.3% of colonized patients in our study, which highlights the importance of laboratory tests for correct identification of the etiologic agent, although the clinical diagnosis of the disease is easily performed and commonly applied 2, 25…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Candida spp. in cervical-vaginal samples and the in vitro susceptibility of isolates

Brandolt

Klafke

Gonçalves

et al. 2017

Brazilian Journal of Microbiology

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Vulvovaginal candidiasis (VVC) is an infection of the genital mucosa caused by different species of the genus Candida. Considering the lack of data on this topic in the south of Brazil, this study aimed to assess the prevalence of Candida spp. in the cervical-vaginal mucosa of patients treated at a university hospital in southern Rio Grande do Sul, as well as the etiology and the susceptibility of the isolates against fluconazole, itraconazole, miconazole and nystatin. Samples were collected at the gynecology clinic of the Federal Hospital of the University of Rio Grande, and the isolates were identified using phenotypic and biochemical tests. The susceptibility analysis was performed according to the CLSI M27-A2 protocol. Of the 263 patients included, Candida spp. was isolated in 27%, corresponding to a prevalence of approximately 15% for both VVC and colonization. More than 60% of the isolates were identified as Candida albicans; C. non-albicans was isolated at a rate of 8.6% in symptomatic patients and 14.3% in asymptomatic patients. The prevalence of resistance against fluconazole and itraconazole was 42% and 48%, respectively; the minimal inhibitory concentration of miconazole ranged from 0.031 to 8 μg/mL, and that of nystatin ranged from 2 to >16 μg/mL. The high rate of resistance to triazoles observed in our study suggests the necessity of the association of laboratory exams to clinical diagnosis to minimize the practice of empirical treatments that can contribute to the development of resistance in the isolates.

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Section: Discussioncontrasting

confidence: 77%

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

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Prevalence of Candida spp. in cervical-vaginal samples and the in vitro susceptibility of isolates

Brandolt

Klafke

Gonçalves

et al. 2017

Brazilian Journal of Microbiology

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“…Compared to the literature, it is observed that this frequency is considerably lower than those reported in other studies (usually at a frequency greater than 30%) 9,15,16 . This was probably because the sample population included in this study was of women attending the outpatient clinic of General Gynecology, which were forwarded by Health Services of the municipality, after screening by the primary care network gynecologist, requiring gynecological interventions (hysterectomy, perineoplasty with sling).…”

Section: Discussioncontrasting

confidence: 81%

Candida Species in the Genital Tract of Women Attending a University Hospital for Gynecological Interventions

Felix

Menezes

Berardi

et al. 2017

BJMHH

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| Introduction: Vulvovaginal candidiasisoccurs in about 75% of all women during reproductive age, and around half of those will have at least one recurrent episode. Objectives: To evaluate the occurrence of Candida species in the genital tract of women attending a clinic of Gynecology and Obstetrics at the University Hospital for gynecological interventions, related to signs and symptoms of infection and also to evaluate the susceptibility to antifungal agents of the Candida isolates. Methods and materials: Samples of vaginal secretions were taken of 128 women during gynecological and colposcopic examination, through sterile swab, to carry out culture for fungi. Susceptibility tests were performed for fluconazole, itraconazole, voriconazole, nystatin and amphotericin B. Results: Twenty (15.6%) patients had positive culture for yeasts identified as: C. albicans (57.1%), C. glabrata (19%), C. parapsilosis complex (4.8%), C. lipolytica (4.8%), Trichosporon sp (9.5%), and Rhodotorula sp (4.8%). Ninety women (70.3%) reported no symptoms and 38 (29.6%) were symptomatic. The most frequent complaints were: discharge, vulval itching, and dyspareunia. All isolates were susceptible to the antifungal agents tested, except for some isolates of C. parapsilosis complex, which showed in vitro resistance to itraconazole. Conclusions: Although Candida species were isolated in only some of the women, C. albicans was the most common species. The more frequent complaints were discharge and vulvar itching. Most of the isolates were susceptible to the antifungals tested.

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“…Porém, têm-se observado um aumento na frequência das espécies não albicans, especialmente Candida glabrata 1,2,4,8 . A maior preocupação reside no fato de que essas outras espécies tendem a ser mais resistentes aos antifúngicos 1,9,10 , considerado um importante fator de recorrência 10 .…”

Section: Abstract: Vulvovaginal Candidiasis Women Treatment Phototherapyunclassified

Tratamento Da Candidíase Vulvovaginal E Novas Perspectivas Terapêuticas: Uma Revisão Narrativa

Leal¹,

Lima²,

Klein³

et al. 2016

RPF

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Introdução: A candidíase vulvovaginal (CVV) é um processo infeccioso do trato geniturinário inferior feminino causada pelo fungo Candida. No Brasil, é o segundo diagnóstico mais comum em ginecologia e tem ocasionado preocupação dos profissionais da saúde devido ao crescente número de casos recorrentes. A dificuldade na abordagem terapêutica da CVV aponta para a relevância do desenvolvimento de estudos que abordem as atuais terapias utilizadas para esta infecção e suas limitações, atentando os profissionais da área a desenvolver a visão crítica acerca do tema e buscar modificações no manejo clínico. Objetivo: Este estudo visa descrever o panorama atual dos tratamentos da CVV e as novas perspectivas terapêuticas. Estratégia Metodológica: Foi desenvolvida uma revisão de literatura contendo artigos em língua inglesa e portuguesa acerca dos atuais tratamentos existentes para CVV e possíveis perspectivas terapêuticas. Resultados: Nota-se que os casos de CVV, principalmente os recorrentes, têm apresentado limitação na resposta aos tratamentos medicamentosos atuais e por isto há uma crescente busca por inovações terapêuticas. Dentre as novas possibilidades, o Diodo Emissor de Luz (LED) azul 405 nm é uma possível modalidade de tratamento, no entanto, necessita-se de mais estudos que comprovem sua eficácia. Conclusão: A terapia antifúngica atual tem apresentado limitações, principalmente nos casos de recorrência e isto fortalece a necessidade de busca de novas modalidades terapêuticas que sejam capazes de tratar o processo infeccioso inibindo os mecanismos de resistência do microorganismo.

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Associação entre cultura de secreção vaginal, características sociodemográficas e manifestações clínicas de pacientes com diagnóstico de candidíase vulvovaginal

Abstract: Despite the high culture positivity and clinical data characteristic of VVC, the symptoms were not pathognomonic. C. albicans is the most prevalent species, but other species are also involved in VVC etiology, such as the emergence of C. lusitaniae.

Cited by 14 publications

References 22 publications

Prevalence of Candida spp. in cervical-vaginal samples and the in vitro susceptibility of isolates

Prevalence of Candida spp. in cervical-vaginal samples and the in vitro susceptibility of isolates

Candida Species in the Genital Tract of Women Attending a University Hospital for Gynecological Interventions

Tratamento Da Candidíase Vulvovaginal E Novas Perspectivas Terapêuticas: Uma Revisão Narrativa

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