Associação entre a suscetibilidade à exposição solar e a ocorrência de câncer de pele em albinos

Moreira, Shirlei Cristina; Rocha, Luciane de Melo; Santo, Layla Damasceno do Espírito; Moreira, Lilia Maria Azevedo

doi:10.9771/cmbio.v12i1.6717

Cited by 6 publications

(7 citation statements)

References 4 publications

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“…The site of tumors was preferentially the head and neck (43%), followed by the trunk (37%) and limbs (20%), mirroring the tendency of greater prevalence in areas most exposed to the sun 11, 12, 24, 68, 83, 96, 97, 104, 110. Reporting similar results to those of the present study, another investigation carried out in Bahia, Brazil showed that of the albinos with skin cancer ( n = 22), 56% had basal cell carcinoma 48 Figure 6Morbimortality associated with skin cancer.…”

Section: Climatic Factors and Skin Cancer In Albinismsupporting

confidence: 90%

“…Reports of studies carried out in Bahia, data from the Association of Persons Living with Albinism in Bahia* State [APALBA] (*http://apalba-albinosdabahia.blogspot.com), informal global references, and the practical experience of the authors indicate that albinos in Brazil, even in major urban centers, suffer prejudice and social exclusion, as well as limited access to specialized medical healthcare and resources. These factors contribute to an increase in the morbimortality associated with the condition, including actinic damage and skin cancer 44, 45, 46, 47, 48…”

Section: Albinism Types and Epidemiologymentioning

confidence: 99%

“…Using the Yates test, a significant relationship between use of sunscreen and absence of development of skin tumors was determined. Among those albinos who had used sunscreens since childhood, only two (11%) had developed skin cancer 48 …”

Section: Climatic Factors and Skin Cancer In Albinismmentioning

confidence: 99%

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Albinism: epidemiology, genetics, cutaneous characterization, psychosocial factors

Marçon

Maia

2019

Anais Brasileiros de Dermatologia

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Oculocutaneous albinism is an autosomal recessive disease caused by the complete absence or decrease of melanin biosynthesis in melanocytes. Due to the reduction or absence of melanin, albinos are highly susceptible to the harmful effects of ultraviolet radiation and are at increased risk of actinic damage and skin cancer. In Brazil, as in other parts of the world, albinism remains a little known disorder, both in relation to epidemiological data and to phenotypic and genotypic variation. In several regions of the country, individuals with albinism have no access to resources or specialized medical care, and are often neglected and deprived of social inclusion. Brazil is a tropical country, with a high incidence of solar radiation during the year nationwide. Consequently, actinic damage and skin cancer occur early and have a high incidence in this population, often leading to premature death. Skin monitoring of these patients and immediate therapeutic interventions have a positive impact in reducing the morbidity and mortality associated with this condition. Health education is important to inform albinos and their families, the general population, educators, medical professionals, and public agencies about the particularities of this genetic condition. The aim of this article is to present a review of the epidemiological, clinical, genetic, and psychosocial characteristics of albinism, with a focus in skin changes caused by this rare pigmentation disorder.

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Section: Climatic Factors and Skin Cancer In Albinismsupporting

confidence: 90%

Section: Albinism Types and Epidemiologymentioning

confidence: 99%

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Albinism: epidemiology, genetics, cutaneous characterization, psychosocial factors

Marçon

Maia

2019

Anais Brasileiros de Dermatologia

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“…Informal references and the authors' experience have indicated that patients with albinism in Brazil, even in large centers, are targets of prejudice and social exclusion and have restricted access to specialized medical care and resources. These factors contribute to the increased morbidity and mortality associated with the condition, which includes actinic damage and skin cancer [19,20].…”

Section: Introductionmentioning

confidence: 99%

Dermatological and Epidemiological Profiles of Patients with Albinism in São Paulo, Brazil, between 2010 and 2017: A Cross-Sectional Study

et al. 2019

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Introduction: Oculocutaneous albinism is an autosomal recessive disease caused by complete absence of or decrease in melanin biosynthesis in melanocytes. Due to the reduction or absence of melanin, albinos are highly susceptible to the harmful effects of ultraviolet radiation and are at greater risk of actinic damage and skin cancer. There are no epidemiological data on the incidence of albinism in Brazil. Objective: To analyze the clinical and epidemiological profile of patients with albinism treated by the Pró-Albino Program of the Dermatology Clinic of Santa Casa de Misericórdia from its beginning in 2010 until 2017. Methods: In this cross-sectional study, the records of all consecutive albino patients admitted to the service in the study period were reviewed. Sociodemographic data, family history, and dermatological clinical data were collected. Results: Between March 2010 and April 2017, 191 patients were admitted, of whom 109 were female (57.07%) and the age range was 0-92 years, with > 30% under the age of 18 years. Consanguinity among that enable the diagnosis and early treatment of these lesions, health education, and the use of photoprotective measures can reduce morbidity and mortality and improve the quality of life of patients with this rare genetic condition.

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“…Studies associating sun exposure and the occurrence of cancer in albino skin lesions treated in a public centre of cancer treatment in the state of Bahia shows that the average age of albinos with cancer was 42.8 years, significantly increased when compared to the average of 65, one year for individuals without albinism (MOREIRA et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Taxa elevada de albinismo oculocutâneo no estado da Bahia, região nordeste do Brasil

et al. 2020

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Taxa elevada de albinismo oculocutâneo no estado da Bahia, região nordeste do BrasilHigh rate of oculocutaneous albinism in the state of Bahia, northeastern of Brazil A B S T R A C TOculocutaneous albinism (OCA) is a detrimental genetic trait that affects the production of melanin, resulting in hypopigmentation of the skin, eyes and hair, with a worldwide distribution but higher prevalence in the African continent. In this article we aim to analyze the OCA distribution in cities of state of Bahia, northeastern Brazil, with high rate of African descent. This study had a descriptive and exploratory approach and used a convenience sample consisted of 481 subjects of both sexes, aged 1-65 years registered in Albinism Association of the State of Bahia (APALBA). It was found high rates of albinism in 34 of these cities, in individuals of different age groups, suggesting a founder effect and also the role of random processes as internal migration, family size, fertility, as well as economic, natural and cultural factors. The occurrence of quilombola communities in some of these cities was also associated with high rates of black population and the increased frequency of albinism. Although the lack of melanin provides greater susceptibility to skin cancer for people with albinism, natural selection does not act against the albinism gene to a severe level. Advances in public health, allied to greater attention to albinism, are factors which may contribute to reduce the deleterious consequences of the disorder.

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Associação entre a suscetibilidade à exposição solar e a ocorrência de câncer de pele em albinos

Cited by 6 publications

References 4 publications

Albinism: epidemiology, genetics, cutaneous characterization, psychosocial factors

Albinism: epidemiology, genetics, cutaneous characterization, psychosocial factors

Dermatological and Epidemiological Profiles of Patients with Albinism in São Paulo, Brazil, between 2010 and 2017: A Cross-Sectional Study

Taxa elevada de albinismo oculocutâneo no estado da Bahia, região nordeste do Brasil

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