Assistive Technology for Promoting Physical and Mental Exercise to Delay Progression of Cognitive Degeneration in Patients with Dementia

Chilukoti, N.; Early, Kevin E.; Sandhu, Shawn; Riley-Doucet, Cheryl; Debnath, Debatosh

doi:10.1109/biocas.2007.4463352

Cited by 19 publications

(20 citation statements)

References 10 publications

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“…In America, this disease is considered as one of the ten causes of mortality. In a study recently conducted in Hopkins university, it has been estimated that in 2050 from each 85 individuals from the earth population, one will be diagnosed with Alzheimer's disease [13]. Micro-array technology is a very powerful method Zahedan J Res Med Sci.…”

Section: Discussionmentioning

confidence: 99%

A Gene Expression Profile of Alzheimer’s Disease Using Microarray Technology

Barati

Ebrahim

2016

Zahedan J Res Med Sci

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Background: Alzheimer's disease is a form of dementia in old age. Alzheimer's disease is an incurable disease, usually shows its symptoms in the seventh decade of human life. This disease can exist in an individual for years without visible symptoms. The causes of this disease is still unknown although many studies have been done on this disease. Alzheimer's disease appears in an old individual based on genetic and accidental factors. Objectives: According to the importance of Alzheimer's disease and lack of a definite treatment for this disease, we decided to identify the effecting genes on this disease by using Micro-array technology. Methods: In this analytical study, Microarray technology was used to identify genes with over and down expression in patients diagnosed with Alzheimer's disease and finally, we introduced up-and down-regulated genes by using Bayes T test. Results: XIST gene, with 8.68652 over expression showed the highest level of over-expression while COL5A2 had 4.561804 downexpression which showed the most changes. Conclusions: Findings of this study, validate the previous assumptions and the only difference is in the expression level of genes which is normal due to differences in the sample.

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Section: Discussionmentioning

confidence: 99%

A Gene Expression Profile of Alzheimer’s Disease Using Microarray Technology

Barati

Ebrahim

2016

Zahedan J Res Med Sci

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“…In America, this disease is considered as one of the ten causes of mortality. In a study recently conducted in Hopkins university, it was estimated that in 2050 from each 85 individuals from the earth population, one will be diagnosed with Alzheimer disease (18). Micro-array technology is a very powerful method providing the opportunity to study the expression of thousands of genes simultaneously and identify thousands of protein interactions (19).…”

Section: Discussionmentioning

confidence: 99%

Identification of Genes Involved in the Early Stages of Alzheimer Disease Using a Neural Network Algorithm

Barati

Ebrahimi

2016

Gene Cell Tissue

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Alzheimer disease is one form of dementia in old age. Alzheimer disease, the incurable disease, which is usually in the seventh decade of human life, shows its symptoms. The disease may be present for years without clinical symptoms. The current study identified the genes with altered expression in patients with Alzheimer disease. The important sequence of each gene in Alzheimer disease was found and introduced as a biomarker of this disease. The present study used microarray libraries related to Alzheimer disease. Finally, the data were weighted using 10 data mining methods, including methods such as support vector machine (SVM), deviation, information gain ratio and the Gini coefficient. Sequences with least two algorithm weights above 0.5 were selected as the most important sequences. Then, a neural network algorithm (neural net, auto multilayer perceptron and perceptron) was run on 11 data bases from the weighted perceptron algorithm, resulting in a careful 97% best performance.

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“…Not one article thematized the relationship between nurses and nursing and disabled people in relation to neuro-advancements, something needed given the contentious debate around the neurotechnology of cochlear implant and certain controversies around brain-computer interfaces. Within the 597 abstracts, the term "assistive technolog*" (AT), obtained n = 8 hit counts, of which n = 6 classified virtual reality as an assistive technology whereby the focus was on therapeutic outcome improvement and prevention of health problems [209][210][211][212][213][214]. In the studies, the following issues were considered by some researchers in relation to assistive technologies: overall usability [209,213,215], effectiveness [211,212,214], user acceptance [213], and financial feasibility [215].…”

Section: Narrative Around Disabled People: Newspapersmentioning

confidence: 99%

“…Within the 597 abstracts, the term "assistive technolog*" (AT), obtained n = 8 hit counts, of which n = 6 classified virtual reality as an assistive technology whereby the focus was on therapeutic outcome improvement and prevention of health problems [209][210][211][212][213][214]. In the studies, the following issues were considered by some researchers in relation to assistive technologies: overall usability [209,213,215], effectiveness [211,212,214], user acceptance [213], and financial feasibility [215]. However, the only role outlined for nurses was in assisting in the use of the technology with patients and no further ethical and social implications were analyzed outside of the medical scope and purpose of such technologies.…”

Section: Narrative Around Disabled People: Newspapersmentioning

confidence: 99%

Neuro-Advancements and the Role of Nurses as Stated in Academic Literature and Canadian Newspapers

Deloria

Wolbring

2019

Societies

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Neurosciences and neurotechnologies (from now on called neuro-advancements) constantly evolve and influence all facets of society. Neuroethics and neuro-governance discourses focus on the impact of neuro-advancements on individuals and society, and stakeholder involvement is identified as an important aspect of being able to deal with such an impact. Nurses engage with neuro-advancements within their occupation, including neuro-linked assistive technologies, such as brain-computer interfaces, cochlear implants, and virtual reality. The role of nurses is multifaceted and includes being providers of clinical and other health services, educators, advocates for their field and their clients, including disabled people, researchers, and influencers of policy discourses. Nurses have a stake in how neuro-advancements are governed, therefore, being influencers of neuroethics and neuro-governance discourses should be one of these roles. Lifelong learning and professional development could be one mechanism to increase the knowledge of nurses about ethical, social, and legal issues linked to neuro-advancements, which in turn, would allow nurses to provide meaningful input towards neuro-advancement discussions. Disabled people are often the recipients of neuro-advancements and are clients of nurses, therefore, they have a stake in the way nurses interact with neuro-advancements and influence the sociotechnical context of neuro-advancements, which include neuro-linked assistive devices. We performed a scoping review to investigate the role of narrative around nurses in relation to neuro-advancements within academic literature and newspapers. We found minimal engagement with the role of nurses outside of clinical services. No article raised the issue of nurses having to be involved in neuro-ethics and neuro-governance discussions or how lifelong learning could be used to gain that competency. Few articles used the term assistive technology or assistive device and no article covered the engagement of nurses with disabled people within a socio-technical context. We submit that the role narrative falls short of what is expected from nurses and shows shortcomings at the intersection of nurses, socio-technical approaches to neuro-assistive technologies and other neuro-advancements and people with disabilities. Neuro-governance and neuroethic discourses could be a useful way for nurses and disabled people to co-shape the socio-technical context of neuro-advancements, including neuro-assistive technologies. Lifelong learning initiatives should be put in place to provide the knowledge necessary for nurses to take part in the neuroethics and neuro-governance discussion.

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Assistive Technology for Promoting Physical and Mental Exercise to Delay Progression of Cognitive Degeneration in Patients with Dementia

Cited by 19 publications

References 10 publications

A Gene Expression Profile of Alzheimer’s Disease Using Microarray Technology

A Gene Expression Profile of Alzheimer’s Disease Using Microarray Technology

Identification of Genes Involved in the Early Stages of Alzheimer Disease Using a Neural Network Algorithm

Neuro-Advancements and the Role of Nurses as Stated in Academic Literature and Canadian Newspapers

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