Assisted reproductive technology and the risk of gestational diabetes mellitus: a systematic review and meta-analysis

Abstract

Background: The use of assisted reproductive technology (ART) is increasing worldwide, and observational studies have indicated that women who conceived by ART have an increased risk of pregnancy complications including gestational diabetes mellitus (GDM). We aimed to determine the risk of GDM among women who conceived with ART by systematic review and meta-analysis. Main text: A systematic literature search was conducted in ISI Web of Knowledge, MEDLINE, Scopus, and Embase through May 2017 for English-language articles using a list of keywords. All studies comparing GDM in women conceived by ART and those who conceived spontaneously were included. Data extraction was performed by two authors independently and discrepancies were resolved by discussion. In total, 48 studies with 91,487 pregnancies conceived through ART and 2,525,234 spontaneously conceived met the inclusion criteria. There was evidence of substantial heterogeneity among these studies (P < 0.001, I 2 = 98.6%). Random effects meta-analysis showed a significant increase in GDM among those who conceived by ART compared with those who conceived spontaneously (pooled relative risk = 1.51, 95% confidence interval = 1.18-1.93). Visual inspection of the funnel plot did not reveal any publication bias, which was supported by Egger's test and Begg's test. Conclusion: The findings of this systematic review indicate that the use of ART treatment is associated with a 1.51fold increase in GDM. Women need to be counselled carefully before undergoing ART treatment about the possibility and risk of GDM.

Substantially Altered Expression Profile of Diabetes/Cardiovascular/Cerebrovascular Disease Associated microRNAs in Children Descending from Pregnancy Complicated by Gestational Diabetes Mellitus—One of Several Possible Reasons for an Increased Cardiovascular Risk

“…Similarly, as other studies [ 258 , 259 , 260 ] we observed that infertility and an infertility treatment may be associated with an increased risk of GDM onset. The incidence of infertility and infertility treatment was significantly higher in groups of mothers with a GDM complicated course of gestation when compared to the group of mothers with normal pregnancies ( Table 2 ).…”

Intralipid infusion at time of embryo transfer in women with history of recurrent implantation failure: A systematic review and meta‐analysis

“…As it is argued to promote healthy implantation and placentation, IVI might reduce the risk of placenta mediated pregnancy complications (e.g. pre‐eclampsia) which are more common in women undergoing ART 32 . Planned long‐term follow‐up of randomized cohort is essential to precisely evaluate such protective effects and aid more robust evidence synthesis on ART add‐ons.…”

“…pre-eclampsia) which are more common in women undergoing ART. 32 Planned longterm follow-up of randomized cohort is essential to precisely evaluate such protective effects and aid more robust evidence synthesis on ART add-ons. Despite our meta-analysis results suggesting IVI intralipid increased both clinical pregnancy rate and live birth, the small number of studies makes it challenging to draw firm conclusions as to the benefit of intralipid.…”

Comparison of the performances of survival analysis regression models for analysis of conception modes and risk of type-1 diabetes among 1985–2015 Swedish birth cohort

“…Diabetic parents pose a higher risk of type-1 diabetes to their children independent of the conception method. This is plausible as a systematic review has reported a 51% significant increase in diabetes mellitus among parents who conceived by ART compared with those who conceived spontaneously [ 42 ].…”