Assisted hatching—a meta-analysis of randomized controlled trials

Sallam, Hassan; Sadek, Sameh; Agameya, Abdel-Fattah

doi:10.1016/s0015-0282(03)02071-5

Cited by 24 publications

(42 citation statements)

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“…Randomized trials of assisted hatching on all embryos without any selection, revealed that there is no difference in the implantation and pregnancy rates between the treatment and control groups [7,66]. In a recently published meta-analysis of randomized controlled studies on assisted hatching for all patients treated with IVF/ICSI (13 studies out of 165 fitted the selection criteria); the results of the meta-analysis could not be accepted because of the heterogeneity of the studies which may be due to the different techniques used or due to different patient populations studied [70]. On the other hand, there is convincing evidence in the literature that assisted hatching may increase the implantation capability of some of the embryos.…”

Section: Results Of Ahmentioning

confidence: 99%

“…Sallam et al, concluded after conducting a series of sensitivity analyses, that assisted hatching improves the pregnancy rate, implantation rate and the ongoing pregnancy rate significantly for patients with poor prognosis treated with IVF/ICSI, particularly those with two or more previous failures [70].…”

Section: Results Of Ahmentioning

confidence: 99%

“…Pregnancy and implantation rates appear to be significantly increased by assisted hatching for women with unexplained recurrent implantation failure in at least two, and usually more, previous IVF cycles. However, it would of course be preferable to identify patients who would benefit from assisted hatching before they have unsuccessful IVF cycles [70] (Figs. 1, 2) The potential of AH in Advanced female age It is well established that IVF success rates decrease with advancing maternal age and many suggestions have been made to explain this reduction in fertility [71].…”

Section: Clinical Application Of Ahmentioning

confidence: 99%

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Assisted hatching in assisted reproduction: a state of the art

Hammadeh

Fischer-Hammadeh

Ali

2010

J Assist Reprod Genet

104

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The World Health Organization estimates that one in six couples experience some delay in conception and an increasing number require treatment by the assisted conception (AC) procedures of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).The implantation rate of embryos resulting from in vitro fertilization cycles is generally less than 20%. The exposure of oocytes and embryos to the artificial conditions of in vitro culture may have negative effects on the embryo's ability to undergo normal hatching, resulting in low rates of implantation following IVF and embryo transfer. Human embryos resulting from superovulation develop more slowly in vitro compared to embryos in vivo, manifest a relatively high degree of cytogenetic abnormalities and undergo cellular fragmentation. Artificially disrupting the zona pellucida is known as assisted hatching (AH) and there is some evidence that embryos that have undergone zona manipulation for assisted hatching tend to implant one day earlier than unhatched embryos. A variety of techniques have since been employed to assist embryo hatching, including partial mechanical zona dissection, zona drilling and zona thinning, making use of acid tyrodes, proteinases, piezon vibrator manipulators and lasers. This review will consider the impact of IVF conditions on zona pellucida physiology, zona hardening, different techniques of assisted hatching, who may benefit from assisted hatching and potential hazards.

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Section: Results Of Ahmentioning

confidence: 99%

Section: Results Of Ahmentioning

confidence: 99%

Section: Clinical Application Of Ahmentioning

confidence: 99%

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Assisted hatching in assisted reproduction: a state of the art

Hammadeh

Fischer-Hammadeh

Ali

2010

J Assist Reprod Genet

104

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“…Higher pregnancy and implantation rates have been reported in cycles with poor prognosis when assisted hatching was applied to transfer embryos (Sallam et al, 2003), although other studies claimed no difference in the outcome (Edirisinghe et al, 1999;Mercader et al, 2001). One study recommended routine application of assisted hatching to increase the implantation potential of embryos (Ali et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Impact of assisted hatching on ART outcome in women with endometriosis

Çiray

Bener²,

Karagenc³

et al. 2005

Human Reproduction

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BACKGROUND: Assisted hatching can improve the implantation rate in cycles with poor outcome. The impact of assisted hatching in embryos from women with endometriosis is not known. Therefore, the hypothesis that the implantation potential of embryos obtained from women with endometriosis can be improved with assisted hatching was tested. METHODS: In a prospective randomized study, transfer embryos obtained from 60 women with endometriosis were hatched using a laser system and compared to embryos obtained from patients with the same diagnosis which were left intact (n 5 30). RESULTS: The characteristics of cycles were similar between groups. The pregnancy (40% zona intact, 28.3% assisted hatching), and implantation rates (19.4% zona intact, 17.8% assisted hatching) did not differ in endometriosis cycles regardless of assisted hatching. CONCLUSION: Assisted hatching does not improve outcome in women with endometriosis undergoing assisted reproduction.

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“…With the pool of evidence, restricted group of cases were proposed to have favorable outcome with the AH (8)(9)(10). As a consequence, two meta-analysis demonstrated that AH have positive impact on cycle outcome for the patients with repeated implantation failures (11,12). Some different techniques for AH have been introduced up to date including chemical, mechanical, enzymatic, piezo-micromanipulation or laser.…”

Section: Introductionmentioning

confidence: 99%

Effect of Total versus Partial Assisted Hatching on the Clinical Pregnancy Rates in Assisted Reproduction Technology

Bilgiç

Özkaya

Abide

et al. 2019

Gynecol Obstet Reprod Med

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OBJECTIVE:The objective of this study was to investigate the effect of total or partial assisted hatching on the clinical pregnancy rates in assisted reproduction technology. STUDY DESIGN:This was a case-control study conducted from the beginning of January 2016 to the end of June 2017. A total of 404 cycles were included in this case-control study. Study population was divided into 3 groups: Group 1: Partial assisted hatching (n=118), Group 2: Total assisted hatching (n=81) and Control group (n=205). RESULTS:In women of all ages, clinical pregnancy rates were similar between groups with total or partial assisted hatching compared to control group (p>0.05). The rates were also similar in subgroups of women with blastocyst or cleavage stage embryo transfers (p>0.05). Partial or total embryo hatching did not result in favorable outcome compared to control group either in women over 35 or younger than 35 years of age (p>0.05). In whole study group pregnancy rate was significantly higher in group with blastocyst stage embryo transfers (22.4 % versus 48.8%, p<0.05) CONCLUSION: Partial or total assisted hatching do not have any impact on the clinical pregnancy rates, no significant impact was determined in subgroup of women either.

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Assisted hatching—a meta-analysis of randomized controlled trials

Cited by 24 publications

References 0 publications

Assisted hatching in assisted reproduction: a state of the art

Assisted hatching in assisted reproduction: a state of the art

Impact of assisted hatching on ART outcome in women with endometriosis

Effect of Total versus Partial Assisted Hatching on the Clinical Pregnancy Rates in Assisted Reproduction Technology

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