Assignment of the Hepatocyte Growth Factor (HGF) to chromosome 7q22‐qter

Laguda, B; Selden, Clare; Jones, Michael D.; Hodgson, H. J. F.; Spurr, Nigel K.

doi:10.1111/j.1469-1809.1991.tb00415.x

Cited by 7 publications

(2 citation statements)

References 22 publications

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“…In addition, cloning the PTN gene has allowed us to localize it to chromosome 7q33-34, a region of the human chromosome about which relatively little is known. Interestingly, the hepatocyte growth factor (HGF) gene has also recently been localized to human chromosome 7q in the region of 22-qter (Laguda et al, 1991).…”

Section: Resultsmentioning

confidence: 99%

Cloning, nucleotide sequence, and chromosome localization of the human pleiotrophin gene

Milner¹,

Shah²,

Veile³

et al. 1992

Biochemistry

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Pleiotrophin (PTN), midkine (MK), and retinoic acid-induced heparin-binding (RI-HB) protein are members of a recently discovered family of developmentally regulated cytokines. We report here the cloning, sequencing, chromosomal localization, and structural organization of the genomic version of the human PTN gene and its comparison to the mouse MK gene. The PTN gene was found to be arranged in five exons and four introns, in a fashion similar to that of the mouse MK gene. Exon 1, as for MK, does not appear to encode amino acid sequence. As in the case of the MK gene, exon 2 encodes the hydrophobic leader sequence of PTN, which constitutes the beginning of gene translation. The signal peptide cleavage site of both genes lies toward the 3' end of exon 2. Exons 3 and 4 of PTN were most closely related to exons 3 and 4 of the MK gene; in particular, six of the ten cysteine residues were coded for in exon 3 and the remaining 4 in exon 4. The intron-exon splice junctions of both genes occurred through the same residues. The two genes were found to be less closely related in the fifth exon which encodes the highly basic C-terminal domains, the translation termination codon, and the polyadenylation signal of both cDNAs. We also report approximately 2000 bp of the 5' untranslated sequence of the PTN gene and the site of initiation of transcription in human placenta. PTN was localized to human chromosome 7q33-34 by fluorescence in situ hybridization. These data confirm the existence of a new gene family of developmentally regulated cytokines.

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Section: Resultsmentioning

confidence: 99%

Cloning, nucleotide sequence, and chromosome localization of the human pleiotrophin gene

Milner¹,

Shah²,

Veile³

et al. 1992

Biochemistry

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“…adenine analog, 5-fluorouracil, or 6-thioguanine [65]. Amplification at the long arm of chromosome 7 may result in upregulation of the c-Met oncongene and its ligand which are in close proximity on the same chromosome [66]. The c-Met gene product has been implicated in invasion, proliferation, and tumor angiogenesis [67].…”

Section: Genetic Aberrationsmentioning

confidence: 98%

The biological basis for modern treatment of chordoma

Diaz

Cusimano

2011

J Neurooncol

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Chordomas are rare malignant tumors arising in bone of the spheno-occiput, sacrum, and vertebral column which can cause neurological deficit. Current management of chordoma involves safe resection followed by radiation therapy. However, surgical resection is often subtotal and chordoma often recurs despite optimal therapy. Despite years of effort, effective adjuvant therapy for denovo, recurrent and metastatic chordoma are absent and 5-year survival is at best 65%. While no chemotherapeutic agent has been demonstrated to be effective against chordoma in vivo, a greater understanding of the genetics and molecular biology of chordoma is opening up avenues of investigation towards the rational development of targeted therapies. Although enthusiasm for the use of already established or new investigational agents will increase with greater understanding of chordoma biology, laboratory studies of these agents are important prior to incorporation into clinical human trials. The authors review the current state of knowledge regarding chordoma and offer insight into potential new therapies for this rare and challenging tumor.

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Hepatocyte growth factor—How do I know thee? Let me count the ways

LaBrecque¹

1992

Gastroenterology

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Assignment of the Hepatocyte Growth Factor (HGF) to chromosome 7q22‐qter

Abstract: The hepatocyte growth factor (HGF) is thought to be important in the growth of hepatocytes during normal foetal liver growth and following liver damage. The human gene encoding HGF has been mapped to chromosome 7 and shown to be localized in the region q22-qter.

Cited by 7 publications

References 22 publications

Cloning, nucleotide sequence, and chromosome localization of the human pleiotrophin gene

Cloning, nucleotide sequence, and chromosome localization of the human pleiotrophin gene

The biological basis for modern treatment of chordoma

Hepatocyte growth factor—How do I know thee? Let me count the ways

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