Assignment&lt;footref rid="foot01"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/footref&gt; of an ionotropic glutamate receptor-like gene (GRINL1A) to human chromosome 15q22.1by in situ hybridization

Roginski, Raymond S.; Raj, Bhaskara K. Mohan; Finkernagel, Scott; Sciorra, Leonard J.

doi:10.1159/000056971

Cited by 8 publications

(13 citation statements)

References 4 publications

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“…The rat Grinl1a cDNA was isolated as previously described (Roginski et al, 2001). Appropriate primers were synthesized by our institutional DNA core facility.…”

Section: Methodsmentioning

confidence: 99%

“…Fluorescent in situ hybridization, microscopy and imaging were performed as previously described (Roginski et al, 2001). Each in situ hybridization was performed with 35.5 ng biotin-labeled BAC probe.…”

Section: Methodsmentioning

confidence: 99%

“…An intron-containing version of this gene, GRINL1A, has been previously isolated and mapped to human chromosome 15q22.1 (Roginski et al, 2001). The GRINL1B genomic sequence is nearly identical to the GRINL1A cDNA sequence (AF326773); that is, the GRINL1B gene is devoid of introns.…”

Section: Rationale and Significancementioning

confidence: 99%

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Assignment<footref rid="foot01">1</footref> of GRINL1B, a glutamate receptor-like processed gene, to human chromosome 4q12 by in situ hybridization

Raj¹,

Roginski²,

Finkernagel

et al. 2001

Cytogenet Genome Res

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“…The rat Grinl1a cDNA was isolated as previously described (Roginski et al, 2001). Appropriate primers were synthesized by our institutional DNA core facility.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Assignment<footref rid="foot01">1</footref> of GRINL1B, a glutamate receptor-like processed gene, to human chromosome 4q12 by in situ hybridization

Raj¹,

Roginski²,

Finkernagel

et al. 2001

Cytogenet Genome Res

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“…The rat Grinl1a cDNA (accession no. AF326772) was obtained as described in Roginski et al (2001). Primer 21303 (5)-GTTGAGGCGCCAGGAGA-GACTTTTGC, bases 120-145 of AF326772) ends eight bases upstream from the intron (located between bases 152 and 153), while primer 14279 (5)-GGCAATGGTGTCTGAGATCTTTTTACCTTTGTC, bases 175-207 antisense) matches the antisense strand beginning 23 bases downstream.…”

Section: Methodsmentioning

confidence: 99%

“…Glu receptors play major roles in synaptic plasticity as well as in brain injury and neurodegenerative diseases. Recently, a new ionotropic glutamate receptor-like gene, GRINL1A, was identified in the rat and human genomes and mapped to human chromosome 15q22.1 (Roginski et al, 2001). Here we report the identification and genetic linkage mapping of Grinl1a, the mouse orthologue.…”

Section: Rationale and Significancementioning

confidence: 99%

The mouse orthologue of the human ionotropic glutamate receptor-like gene (GRINL1A) maps<footref rid="foot01">1</footref> to mouse chromosome 9

Wydner

Raj

Sciorra

et al. 2001

Cytogenet Genome Res

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Polymorphisms in the GAD2 gene‐region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders

Unschuld

Ising

Specht

et al. 2009

American J of Med Genetics Pt B

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Glutamate decarboxylase (GAD) is the rate limiting enzyme for conversion of glutamic acid to gamma-aminobutyric acid (GABA). The GAD 65 kDa isoform is encoded by the gene GAD2 and is mainly expressed in synaptic terminals. It serves as an apoenzyme, which shows enhanced availability in situations of stress, responding to short-term demands for GABA. We analyzed 18 single nucleotide polymorphisms (SNPs) in the GAD2-gene region for associations with psychiatric diagnosis and behavioral inhibition (BI) derived from the personality traits neuroticism and extraversion as defined by the Eysenck Personality Questionaire (EPQ). A total of 268 patients with anxiety disorder (AD), 541 with unipolar depression (MD), and 541 healthy controls were included. We observe associations for five tag-SNPs with BI in the AD- and control samples as well as two additional case-control associations in the MD-sample. The associated SNPs lie within a 16KB linkage disequilibrium-block, including putative 5' GAD2-promoter-elements as well as the 3' end of the gene MYO3A. Using open access mRNA-expression data, we could show that BI-associated SNPs appear to be associated with differences in MYO3A- but not GAD2 lymphoblastoid-mRNA expression levels. These results support earlier studies that suggest associations of polymorphisms within the GAD2 locus with anxiety and affective disorders. However, data from expression studies imply that these polymorphisms could tag functional effects on the neighboring gene MYO3A, which is also expressed in the brain, including the cingulate cortex and the amygdala.

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Assignment<footref rid="foot01"><sup>1</sup></footref> of an ionotropic glutamate receptor-like gene (GRINL1A) to human chromosome 15q22.1by in situ hybridization

Cited by 8 publications

References 4 publications

Assignment<footref rid="foot01"><sup>1</sup></footref> of GRINL1B, a glutamate receptor-like processed gene, to human chromosome 4q12 by in situ hybridization

Assignment<footref rid="foot01"><sup>1</sup></footref> of GRINL1B, a glutamate receptor-like processed gene, to human chromosome 4q12 by in situ hybridization

The mouse orthologue of the human ionotropic glutamate receptor-like gene (GRINL1A) maps<footref rid="foot01"><sup>1</sup></footref> to mouse chromosome 9

Polymorphisms in the GAD2 gene‐region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders

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