Assessments of Valsartan in the presence of Nebivolol or Amlodipine in solid formulations and its discriminative dissolution behavior via RP‑HPLC and RP‑UPLC methods.

Application of two different spectrophotometric approaches for the determination of a new antihypertensive combination: Graphical and statistical representation of the data

“…The advanced concentration value method is a new approach derived from concentration value method which eliminate the use of regression equation and lets the recording of the concentration of the studied drug directly throw the spectrum with good accuracy and precision. The developed methods simple, accurate and also have the advantage of didn't require preceding treatment, complicated steps or use of organic harmful solvents like that usually used in the reported methods HPLC [9][10][11][12][13][14][15][16][17], LC-MS/MS [18], and spectrophotometry [19][20][21]. Although the use of ACV was easier and lower the manipulation steps, but in CC, obtaining the zero-order absorption spectrum ensures the drug profile and working at λmax ensured maximum accuracy and precision.…”

“…During the literature survey, many methods were found for the analysis of both NEB and VAL in its combined dosage form. Those methods include HPLC [9][10][11][12][13][14][15][16][17], LC-MS/MS [18], and spectrophotometry [19][20][21]. The aim of the study is to apply different approaches to determine the drug studied in its zeroorder absorption spectrum without interference from one another.…”