Assessment tools for social cognition in epilepsy

Bauer, Júlia; Kegel, Lorena; Steiger, Bettina K.; Jokeit, Hennric

doi:10.1007/s10309-019-0260-z

Cited by 8 publications

(4 citation statements)

References 14 publications

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“…These results might be attributable to the implicit nature of the lexical decision paradigm and could point to independent processing of emotional information in reading, despite known altered explicit executive functioning in JME ( 37 , 39 , 40 , 47 ). In addition, this result could suggest rather unaffected implicit emotion processing in patients with JME and could emphasize the importance of a differentiation of the implicit and explicit nature of tasks used in studying emotion processing, considering that most tasks used are of explicit nature ( 25 – 27 , 29 , 95 – 98 ). Error rates revealed a significant main effect of negativity, driven by higher error rates in response to negative as compared to neutral words, and an interaction, showing higher error rates in response to words with high fear values and with negative valence compared to words with high fear values and neutral valence.…”

Section: Discussionmentioning

confidence: 84%

Emotional Word Processing in Patients With Juvenile Myoclonic Epilepsy

Rainer

Kronbichler²,

Kuchukhidze³

et al. 2022

Front. Neurol.

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ObjectiveAccording to Panksepp's hierarchical emotion model, emotion processing relies on three functionally and neuroanatomically distinct levels. These levels comprise subcortical networks (primary level), the limbic system (secondary level), and the neocortex (tertiary level) and are suggested to serve differential emotional processing. We aimed to validate and extend previous evidence of discrete and dimensional emotion processing in patient with juvenile myoclonic epilepsy (JME).MethodsWe recorded brain activity of patients with JME and healthy controls in response to lexical decisions to words reflecting the discrete emotion fear and the affective dimension negativity previously suggested to rely on different brain regions and to reflect different levels of processing. In all study participants, we tested verbal cognitive functions, as well as the relationship of psychiatric conditions, seizure types and duration of epilepsy and emotional word processing.ResultsIn support of the hierarchical emotion model, we found an interaction of discrete emotion and affective dimensional processing in the right amygdala likely to reflect secondary level processing. Brain activity related to affective dimensional processing was found in the right inferior frontal gyrus and is suggested to reflect tertiary level processing. Psychiatric conditions, type of seizure nor mono- vs. polytherapy and duration of epilepsy within patients did not have any effect on the processing of emotional words. In addition, no differences in brain activity or response times between patients and controls were observed, despite neuropsychological testing revealed slightly decreased verbal intelligence, verbal fluency and reading speed in patients with JME.SignificanceThese results were interpreted to be in line with the hierarchical emotion model and to highlight the amygdala's role in processing biologically relevant stimuli, as well as to suggest a semantic foundation of affective dimensional processing in prefrontal cortex. A lack of differences in brain activity of patients with JME and healthy controls in response to the emotional content of words could point to unaffected implicit emotion processing in patients with JME.

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Section: Discussionmentioning

confidence: 84%

Emotional Word Processing in Patients With Juvenile Myoclonic Epilepsy

Rainer

Kronbichler²,

Kuchukhidze³

et al. 2022

Front. Neurol.

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“…In terms of clinical practice recommendations, given the prevalence of ToM and FER impairments in adults with epilepsy ( 24 , 135 , 136 ), we encourage clinicians to be vigilant about indicators of social cognitive impairment in adult patients with TLE, and our results support inclusion of ToM and FER measures in routine neuropsychological testing in adult patients with TLE ( 137 ). Additional, given the diversity and complexity of current ToM and FER measures ( 21 , 138 , 139 ) and the fact that few ToM and FER measures have been adjusted and standardized specifically for patients with epilepsy ( 140 ), we propose the development of comprehensive, ecologically valid, and economically feasible standardized social cognitive assessment tools for patients with epilepsy. From a therapeutic perspective, interventions targeting social cognition may be an effective approach to address social difficulties in adults with TLE.…”

Section: Discussionmentioning

confidence: 99%

Theory of mind and facial emotion recognition in adults with temporal lobe epilepsy: A meta-analysis

Zhao

et al. 2022

Front. Psychiatry

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BackgroundMounting studies have investigated impairments in social cognitive domains (including theory of mind [ToM] and facial emotion recognition [FER] in adult patients with temporal lobe epilepsy (TLE). However, to date, inconsistent findings remain.MethodsA search of PubMed, Web of Science, and Embase databases was conducted until December 2021. Hedges g effect sizes were computed with a random-effects model. Meta-regressions were used to assess the potential confounding factors of between-study variability in effect sizes.ResultsThe meta-analysis included 41 studies, with a combined sample of 1,749 adult patients with TLE and 1,324 healthy controls (HCs). Relative to HCs, adult patients with TLE showed large impairments in ToM (g = −0.92) and cognitive ToM (g = −0.92), followed by medium impairments in affective ToM (g = −0.79) and FER (g = −0.77). Besides, no (statistically) significant differences were observed between the magnitude of social cognition impairment in adult with TLE who underwent and those who did not undergo epilepsy surgery. Meta-regressions exhibited that greater severity of executive functioning was associated with more severe ToM defects, and older age was associated with more severe FER defects.ConclusionsResults of this meta-analysis suggest that adult patients with TLE show differential impairments in the core aspects of social cognitive domains (including ToM and FER), which may help in planning individualized treatment with appropriate cognitive and behavioral interventions.

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“…NEmo 11 assesses sociocognitive processes using multimodal tasks based on dynamic and highly ecological stimulus material. The following NEmo subtests were used to evaluate emotion recognition in our participants (for more details, see Bauer et al 11 …”

Section: Methodsmentioning

confidence: 99%

Recognition and perception of emotions in juvenile myoclonic epilepsy

Rainer,

Kuchukhidze,

Trinka

et al. 2023

Epilepsia

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ObjectivePerception and recognition of emotions are fundamental prerequisites of human life. Patients with juvenile myoclonic epilepsy (JME) may have emotional and behavioral impairments which might influence socially desirable interactions. We aimed to investigate perception and recognition of emotions in patients with JME by means of neuropsychological tests and functional MRI (fMRI).MethodsSixty‐five patients with JME (median age 27 years, IQR 23–34) were prospectively recruited at the Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Salzburg, Austria. Patients were compared to 68 healthy controls (median age 24 years, IQR 21–31), matched for sex, age and education. All study participants underwent the Networks of Emotion Processing test battery (NEmo), an fMRI paradigm of “dynamic fearful faces”, structured interview for psychiatric and personality disorders and comprehensive neuropsychological testing.ResultsJME patients versus healthy controls, demonstrated significant deficits in emotion recognition in facial and verbal tasks of all emotions, especially fear. fMRI revealed decreased amygdala activation in JME patients as compared to healthy controls. Patients were at a higher risk of experiencing psychiatric disorders as compared to healthy controls. Cognitive evaluation revealed impaired attentional and executive functioning, namely psychomotor speed, tonic alertness, divided attention, mental flexibility, and inhibition of automated reactions. Duration of epilepsy correlated negatively with parallel prosodic and facial emotion recognition in NEmo. Deficits in emotion recognition were not associated with psychiatric comorbidities, impaired attention and executive functions, types of seizures and treatment.SignificanceThis prospective study demonstrated that as compared to healthy subjects, patients with JME had significant deficits in recognition and perception of emotions as shown by neuropsychological tests and fMRI. The results of this study may have importance for psychological/psychotherapeutical interventions in the management of patients with JME.

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Assessment tools for social cognition in epilepsy

Cited by 8 publications

References 14 publications

Emotional Word Processing in Patients With Juvenile Myoclonic Epilepsy

Emotional Word Processing in Patients With Juvenile Myoclonic Epilepsy

Theory of mind and facial emotion recognition in adults with temporal lobe epilepsy: A meta-analysis

Recognition and perception of emotions in juvenile myoclonic epilepsy

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