Assessment of Zinc-Bound Phosphate-Based Glass-Coated Denture-Relining Material with Antifungal Efficacy for Inhibiting Denture Stomatitis

Abstract

This study investigated the surface properties, biocompatibility, and antifungal activity against Candida albicans of a denture-relining material coated with zinc-bound phosphate-based glass. First, zinc-bound phosphate-based glass was fabricated. A polymerized denture-relining disk was coated with zinc-bound phosphate-based glass (2%, 4%, and 6%). The surface properties of the control and experimental groups were measured, including the wettability, microhardness, color difference, and gloss. The biocompatibility was evaluated using the MTT assay according to ISO 10993-5. The antifungal activity was investigated by counting the number of colony-forming units of Candida albicans. The results were analyzed using a one-way ANOVA and Tukey’s test (p = 0.05). The results of this study indicate that, despite the antimicrobial effect of zinc-bound phosphate-based glass, a coated denture-relining material does not degrade the surface properties and biocompatibility. Therefore, this novel material is considered promising for use as a dental material with antimicrobial properties that can potentially prevent denture stomatitis.

Poly (Methyl Methacrylate)-Containing Silver-Phosphate Glass Exhibits Potent Antimicrobial Activity without Deteriorating the Mechanical and Biological Properties of Dental Prostheses

“…Silver disrupts bacterial cell membranes and the functions of crucial metabolic proteins and enzymes [ 17 ]. Phosphate glass can be used as a carrier for silver ions [ 7 , 19 ]. Previous studies demonstrate that silver-phosphate glass has bactericidal properties against various pathogens, such as Staphylococcus epidermidis , Enterococcus faecalis , and Streptococcus mutans [ 18 , 21 ].…”

“…Moreover, with the development of a new dental prosthesis, a suitable polymer is also developed [ 5 ]. Although PMMA is the most widely used material for denture bases because of its good aesthetics, low absorption and solubility, and nontoxicity to the human body, it has the disadvantage of having poor antimicrobial properties [ 1 , 6 , 7 ]. For materials intended for dental applications, it is important to consider the adhesion of various microorganisms present in the oral cavity to the material [ 8 , 9 ].…”

“…Recently, a method for stably binding metal ions and slowly dissolving them over time to induce an antimicrobial effect has been developed, and studies using this method on glass are being actively conducted [ 18 , 19 ]. The addition of antimicrobial substances to glass has an inhibitory effect on bacterial and fungal growth [ 7 ]. Phosphate-based glass controls the dissolution rate of the phosphate ions by slowly releasing the ions over a long period [ 20 ].…”