Assessment of Yqh translocations.

Abstract

Two initially presumed Yqh translocations, one to Xp and another to 21p, were assessed by conventional banding procedures, 5-azacytidine treatment, electron microscopy, and fluorescence in situ hybridisation. While the Yqh nature of the heterochromatic block from Xp was confirmed, this was not the case with the 21ph + variant. In conclusion, conventional banding techniques are insufficient to diagnose Y;G translocations.

Prenatal detection of a de novo Yqh-acrocentric translocation

“…Follow-up at 7 months showed normal growth and development. We have shown that conventional cytogenetics and molecular cytogenetics are complimentary techniques in diagnosis of rare chromosomal rearrangement involving chromosome Y [17]. While conventional CBG banding demonstrated that the extra material translocated onto the acrocentric chromosome was heterochromatic in nature, molecular techniques identified the chromosome Y origin of the heterochromatic material.…”

A Prevalent Y;15 Translocation in the Ethiopian Beta Israel Community in Israel

“…In the case of autosomes, the short arms of the acrocentric chromosomes, mainly of chromosome 15, are most frequently involved in the rearrangement, whereas the distal short arm of the X chromosome is the most common acceptor site in sex chromosomes [Fernández et al, 1994]. Hsu [1994] reviewed the results of 50 cases of postnatal Y;A translocations.…”