Using 2001 and 2016 land use (LU) data and three developed deforestation LU scenarios, namely Deforest I, II and III, the possible impacts of the ongoing land use land cover change (LULCC) over West Africa (WA) and the uncertainty regarding the impacts on regional climate were assessed. Twelve Weather Research and Forecasting (WRF) model simulations were configured with the default and integrated MODIS satellite dataset for two sets of 3 months (December-February DJF 2011-2012 and July-September JAS 2012) over WA. Between 2001 and 2016, changes that occurred in precipitation, tempera-ture and dew point temperature due to LULCC are mostly not significant at the 95% level with a decrease of 0.8, 0.0 and 0.1%, respectively. Deforest I, II and III caused significant changes with an increase of 44.4, 44.7, 41.5%; 0.8, 0.9, 1.1%; and 0.3, 0.1, −0.2%, respectively, for precipitation, temperature and dew point temperature. Precipitation was lower in the simulation with 2016