Assessment of wheezing frequency and viral etiology on childhood and adolescent asthma risk

Anderson, Halie M.; Lemanske, Robert F.; Evans, Michael D.; Gangnon, Ronald E.; Pappas, T.E.; Grindle, Kristine A.; Bochkov, Yury A.; Gern, James E.; Jackson, Daniel J.

doi:10.1016/j.jaci.2016.07.031

Cited by 16 publications

(4 citation statements)

References 10 publications

(20 reference statements)

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“…In our study we explored the role of RANTES in the resolution of asthma. To this end we examined the effect of RV on RANTES levels, since RV is implicated in the pathogenesis of asthma as well as its exacerbations ( Kennedy et al., 2019 ; Anderson et al., 2017 ). RV infection in vitro is known to compromise the type 1 IFN and IFNγ response in PBMCs ( Papadopoulos et al., 2002 ).…”

Section: Discussionmentioning

confidence: 99%

Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma

Mirzakhani

Krause

et al. 2021

iScience

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Summary RANTES is implicated in allergic asthma and in T cell-dependent clearance of infection. RANTES receptor family comprises CCR1, CCR3, and CCR5, which are G-protein-coupled receptors consisting of seven transmembrane helices. Infections with respiratory viruses like Rhinovirus cause induction of RANTES production by epithelial cells. Here, we studied the role of RANTES in the peripheral blood mononuclear cells in cohorts of children with and without asthma and validated and extended this study to the airways of adults with and without asthma. We further translated these studies to a murine model of asthma induced by house dust mite allergen in wild-type RANTES and CCR5-deficient mice. Here we show an unpredicted therapeutic role of RANTES in the resolution of allergen-induced asthma by orchestrating the transition of effector GATA-3+CD4+ T cells into immune-regulatory-type T cells and inflammatory eosinophils into resident eosinophils as well as increased IL-10 production in the lung.

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Section: Discussionmentioning

confidence: 99%

Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma

Mirzakhani

Krause

et al. 2021

iScience

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“…(ii) Environmental factors. Environmental factors may also influence the incidence of disease caused by respiratory viral infection either alone or with other underlying factors such as asthma (50). These factors may include the number of siblings in family, environmental smoking exposure (51), air pollution, climatic conditions, or weather (52,53).…”

Section: Epidemiology and Clinical Presentation Of Acute Respiratory mentioning

confidence: 99%

Practical Guidance for Clinical Microbiology Laboratories: Viruses Causing Acute Respiratory Tract Infections

et al. 2018

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SUMMARYRespiratory viral infections are associated with a wide range of acute syndromes and infectious disease processes in children and adults worldwide. Many viruses are implicated in these infections, and these viruses are spread largely via respiratory means between humans but also occasionally from animals to humans. This article is an American Society for Microbiology (ASM)-sponsored Practical Guidance for Clinical Microbiology (PGCM) document identifying best practices for diagnosis and characterization of viruses that cause acute respiratory infections and replaces the most recent prior version of the ASM-sponsored Cumitech 21 document,Laboratory Diagnosis of Viral Respiratory Disease, published in 1986. The scope of the original document was quite broad, with an emphasis on clinical diagnosis of a wide variety of infectious agents and laboratory focus on antigen detection and viral culture. The new PGCM document is designed to be used by laboratorians in a wide variety of diagnostic and public health microbiology/virology laboratory settings worldwide. The article provides guidance to a rapidly changing field of diagnostics and outlines the epidemiology and clinical impact of acute respiratory viral infections, including preferred methods of specimen collection and current methods for diagnosis and characterization of viral pathogens causing acute respiratory tract infections. Compared to the case in 1986, molecular techniques are now the preferred diagnostic approaches for the detection of acute respiratory viruses, and they allow for automation, high-throughput workflows, and near-patient testing. These changes require quality assurance programs to prevent laboratory contamination as well as strong preanalytical screening approaches to utilize laboratory resources appropriately. Appropriate guidance from laboratorians to stakeholders will allow for appropriate specimen collection, as well as correct test ordering that will quickly identify highly transmissible emerging pathogens.

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“…Notably, it was reported that ~ 90% of children with RV wheezing illness in the third year had developed asthma by the sixth year [ 64 ]. The COAST birth cohort study revealed a significant role of RVs in pediatric wheezing illness and development of asthma [ 81 – 84 ]. RV was associated with asthma at 13 years as well as significantly reduced lung function measures compared to measures observed with exposure to other respiratory viruses.…”

Section: Clinical Studies: Rv and The Development Of Wheeze And Ahrmentioning

confidence: 99%

Modulation of airway hyperresponsiveness by rhinovirus exposure

Kennedy

Kurten

et al. 2018

Respir Res

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Rhinovirus (RV) exposure has been implicated in childhood development of wheeze evoking asthma and exacerbations of underlying airways disease. Studies such as the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) and Childhood Origins of ASThma (COAST) have identified RV as a pathogen inducing severe respiratory disease. RVs also modulate airway hyperresponsiveness (AHR), a key characteristic of such diseases. Although potential factors underlying mechanisms by which RV induces AHR have been postulated, the precise mechanisms of AHR following RV exposure remain elusive.A challenge to RV-related research stems from inadequate models for study. While human models raise ethical concerns and are relatively difficult in terms of subject recruitment, murine models are limited by susceptibility of infection to the relatively uncommon minor group (RV-B) serotypes, strains that are generally associated with infrequent clinical respiratory virus infections. Although a transgenic mouse strain that has been developed has enhanced susceptibility for infection with the common major group (RV-A) serotypes, few studies have focused on RV in the context of allergic airways disease rather than understanding RV-induced AHR. Recently, the receptor for the virulent RV-C CDHR3, was identified, but a dearth of studies have examined RV-C-induced effects in humans.Currently, the mechanisms by which RV infections modulate airway smooth muscle (ASM) shortening or excitation-contraction coupling remain elusive. Further, only one study has investigated the effects of RV on bronchodilatory mechanisms, with only speculation as to mechanisms underlying RV-mediated modulation of bronchoconstriction.

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Assessment of wheezing frequency and viral etiology on childhood and adolescent asthma risk

Cited by 16 publications

References 10 publications

Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma

Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma

Practical Guidance for Clinical Microbiology Laboratories: Viruses Causing Acute Respiratory Tract Infections

Modulation of airway hyperresponsiveness by rhinovirus exposure

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