Assessment of volumetric scale-up law for processing of a sustained release formulation on co-rotating hot-melt extruders

Renterghem, J. Van; Steene, S. Van de; Digkas, Tryfon; Richter, Margarethe; Vervaet, Chris; Beer, Thomas De

doi:10.1016/j.ijpharm.2019.118587

Cited by 9 publications

(3 citation statements)

References 10 publications

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“…Increasing the screw speed, together with an increase in the screw and barrel size will achieve exponential upscaling. Under volumetric scaling, the throughput can be increased to the power of 3 with an increase in outer screw diameter (D) 73 , 74 , yet the various relevant processing parameters are needed to be considered and optimized for the successful scale-up 75 , 76 . where Q is throughput, D is outer diameter of screw and N is screw rotation speed.…”

Section: Discussionmentioning

confidence: 99%

Biocomposite thermoplastic polyurethanes containing evolved bacterial spores as living fillers to facilitate polymer disintegration

Kim,

Noh,

White

et al. 2024

Nat Commun

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The field of hybrid engineered living materials seeks to pair living organisms with synthetic materials to generate biocomposite materials with augmented function since living systems can provide highly-programmable and complex behavior. Engineered living materials have typically been fabricated using techniques in benign aqueous environments, limiting their application. In this work, biocomposite fabrication is demonstrated in which spores from polymer-degrading bacteria are incorporated into a thermoplastic polyurethane using high-temperature melt extrusion. Bacteria are engineered using adaptive laboratory evolution to improve their heat tolerance to ensure nearly complete cell survivability during manufacturing at 135 °C. Furthermore, the overall tensile properties of spore-filled thermoplastic polyurethanes are substantially improved, resulting in a significant improvement in toughness. The biocomposites facilitate disintegration in compost in the absence of a microbe-rich environment. Finally, embedded spores demonstrate a rationally programmed function, expressing green fluorescent protein. This research provides a scalable method to fabricate advanced biocomposite materials in industrially-compatible processes.

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Section: Discussionmentioning

confidence: 99%

Biocomposite thermoplastic polyurethanes containing evolved bacterial spores as living fillers to facilitate polymer disintegration

Kim,

Noh,

White

et al. 2024

Nat Commun

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“…Such differences typically occur when using pilot plant or industrial data. With regard to an upscaling of the production processes [34], some efficiency gains can be expected. For comparison between PP-GF and the CA-compounds, energy consumption during extrusion is measured for all materials in compounding studies on the same extruder.…”

Section: Influence/variability Of Fibrillation and Compoundingmentioning

confidence: 99%

A Comparative Life Cycle Assessment of a New Cellulose-Based Composite and Glass Fibre Reinforced Composites

Liu,

Lask,

Kupfer

et al. 2023

J Polym Environ

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The use of renewable lightweight materials and the adoption of cleaner production are two effective approaches to reduce resource consumption, which contributes to meeting the industry’s environmental impact targets. In a previous study we found, that a miscanthus fibre reinforced cellulose acetate (CA-Miscanthus, 25 wt.%) can be a bio-based alternative to glass fibre reinforced polypropylene (PP-GF, 20 wt.%), as both materials exhibit similar mechanical properties. However, only limited information on the environmental benefits of using bio-based composites instead of their petroleum-based counterparts are available. In this study, we compare the environmental impact of ready to use compound of both materials in the cradle to gate system boundaries, including fibre cultivation, fractionation and refining, fibre pretreatment, and compounding. The functional unit is chosen based on the equivalent function of both materials. The environmental impact is determined using the Product Environmental Footprint (PEF) methodology. The results reveal that the CA-Mis composite has a higher environmental impact than the PP-GF composite in all categories observed, despite its biomass origin. As the primary reason for the high impact, the acetic anhydride use during CA production is identified. The study indicates that, though the bio-composite CA-Mis has mechanical properties comparable to PP-GF composites, it is not as eco-friendly as we initially assumed it to be.

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“…To increase the understanding of the process, 1D simulations can serve as a fairly easy to use option (15)(16)(17). This is especially important in early formulation processes in small scale, as viscous dissipation can be easily compensated by conducted heat or cooling from the barrel, which is not the case at larger scales; i.e., adiabatic conditions by geometric scale from small scale can be easily overlooked (15,18,19).…”

Section: Introductionmentioning

confidence: 99%

ASD Formation Prior to Material Characterization as Key Parameter for Accurate Measurements and Subsequent Process Simulation for Hot-Melt Extrusion

2022

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Process simulation facilitates scale-up of hot-melt extrusion (HME) and enhances proper understanding of the underlying critical process parameters. However, performing numeric simulations requires profound knowledge of the employed materials’ properties. For example, an accurate description of the compounds’ melt rheology is paramount for proper simulations. Hence, sample preparation needs to be optimized to yield results as predictive as possible. To identify the optimal preparation method for small amplitude oscillatory shear (SAOS) rheological measurements, binary mixtures of hydroxypropylmethylcellulose acetate succinate or methacrylic acid ethyl acrylate copolymer (Eudragit L100-55) together with the model drugs celecoxib and ketoconazole were prepared. The physical powder mixtures were introduced into the SAOS as a compressed tablet or a disk prepared via vacuum compression molding (VCM). Simulations with the derived parameters were conducted and compared to lab-scale extrusion trials. VCM was identified as the ideal preparation method resulting in the highest similarity between simulated and experimental values, while simulation based on conventional powder-based methods insufficiently described the HME process.

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Assessment of volumetric scale-up law for processing of a sustained release formulation on co-rotating hot-melt extruders

Cited by 9 publications

References 10 publications

Biocomposite thermoplastic polyurethanes containing evolved bacterial spores as living fillers to facilitate polymer disintegration

Biocomposite thermoplastic polyurethanes containing evolved bacterial spores as living fillers to facilitate polymer disintegration

A Comparative Life Cycle Assessment of a New Cellulose-Based Composite and Glass Fibre Reinforced Composites

ASD Formation Prior to Material Characterization as Key Parameter for Accurate Measurements and Subsequent Process Simulation for Hot-Melt Extrusion

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