Assessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

Young, Melissa; Ou, Jiangda; Duong, Minh-Cam; Luo, Hanqi; Beyh, Yara S.; Meng, Junling; Gernand, Alison D.; Roth, Daniel; Suchdev, Parminder S.

doi:10.1016/j.ajcnut.2022.10.018

Cited by 3 publications

(3 citation statements)

References 45 publications

(60 reference statements)

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“…Young et al 13 retrospectively analyzed the data of 9880 preschool children and 14,749 nonpregnant females from nutrition surveys and correlated inflammation biomarkers with 25(OH)D concentration without finding a significant association.…”

Section: Discussionmentioning

confidence: 99%

Is There an Association Between Inflammation and Serum-Vitamin D? – Results of a Retrospective Analysis of Hospitalized Geriatric Patients

Funk,

Trampisch,

Pourhassan

et al. 2024

CIA

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Purpose Vitamin D deficiency is a common finding in geriatric patients. The ESPEN micronutrient guideline states that vitamin D serum levels significantly decrease in the presence of inflammation and should be interpreted with caution. This is of great interest for hospital care and would imply a significant change to the current approach to hospitalized patients with suspected vitamin D deficiency. Patients and methods To evaluate the association of vitamin D and inflammation, we reanalyzed the data set of serum 25(OH)D-Levels of 687 consecutive geriatric hospitalized patients of a previously published study. Results We found that vitamin D deficiency (<20 ng/dl) was prevalent in 78.0% and vitamin D insufficiency (20–30 ng/dl) in 9.9% of patients. Sperman’s correlation showed a significant but very weak correlation (R = −0.100, P < 0.01) of serum vitamin D and C-reactive protein. However, linear regression with the inclusion of age and gender revealed no significant association (beta-coefficient −0.070; p=0.067). Conclusion In this study, we could not confirm a significant and clinically relevant association between serum vitamin D levels and inflammation, contrasting with a previous study. However, longitudinal studies need to be performed to draw a final conclusion.

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Section: Discussionmentioning

confidence: 99%

Is There an Association Between Inflammation and Serum-Vitamin D? – Results of a Retrospective Analysis of Hospitalized Geriatric Patients

Funk,

Trampisch,

Pourhassan

et al. 2024

CIA

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“…In the past few years, BRINDA has published a series of papers providing guidance on how to adjust micronutrient biomarkers, namely retinol binding protein (RBP) [ 8 , 9 ], serum retinol [ 8 , 9 ], serum ferritin [ 8 ], soluble transferrin receptor (sTfR) [ 10 ], serum zinc [ 11 ], serum and red blood cell (RBC) folate [ 12 ], serum B-12 [ 12 ], and vitamin D [ 13 ], using inflammation markers α-1-acid glycoprotein (AGP) and/or C-Reactive Protein (CRP) [ 6 ]. In this section, we will first present whether these micronutrient biomarkers should be adjusted for inflammation, and if so, by which inflammation markers (both AGP and CRP, only AGP, or only CRP).…”

Section: Brinda Inflammation Adjustment Methodsmentioning

confidence: 99%

“…To date, BRINDA has compiled a global micronutrient database with 30 datasets on preschool-age children (PSC) (n ¼ 20,000) from 26 countries and 24 datasets on nonpregnant women of reproductive age (WRA) (n ¼ 56,000) from 23 countries. Using its rich data source, BRINDA published a series of papers to provide methods to adjust for inflammation on key micronutrient biomarkers, such as biomarkers for vitamin A, iron, folate, vitamin B-12, zinc, and vitamin D [4,[6][7][8][9][10][11][12][13]. BRIN-DA's effort to systematically address the role of inflammation in assessing micronutrient status has been recognized by the international community and is included in WHO guidelines [14] and CDC's Micronutrient Manual and Toolkit [15].…”

Section: Introductionmentioning

confidence: 99%

A Practical Guide to Adjust Micronutrient Biomarkers for Inflammation Using the BRINDA Method

Luo¹,

Geng²,

Zeiler³

et al. 2023

The Journal of Nutrition

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Metabolism of vitamin D, Calcium and Phosphorus and their disorders in goats

Sakhniuk,

Hotsuliak

2023

Nauk. vìsn. vet. med.

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The review article presents materials on the metabolism of the mostcommon vitamins of group D ergocalciferol (D2), cholecalciferol (D3), aswell as essential macronutrients Ca and Phosphorus and their disorders ingoats. Since the primary forms of vitamin D (D2 and D3) are biologicallyinactive and must undergo several stages of hydroxylation to be activated,the biological role and importance for the body of active metabolites ofvitamin D3 25OH D3 (synthesised mainly in the liver under the influenceof hepatic cytochromes P450) and 1, 25(OH)2 D3 and 24,25(OH)2 D3 (theirsynthesis occurs via 1α-hydroxylase in the mitochondria of proximal cellsof the convoluted tubules of the kidneys).It is believed that the liver, while playing an important role in themetabolism of vitamin D and its metabolites and producing 25OH D3, isalso the only organ that synthesises DBP, which transports 25OH D3 totissues and maintains its concentration in the circulatory system.Vitamin D becomes biologically active only after the second stageof hydroxylation is completed. Renal 1α-hydroxylase (CYP27B1),regulated by parathyroid hormone (PTH), plays an important role inthe transformation of the extracellular substrate 25OH D3 to 1,25(OH)2D3, which exerts its effect on target cells and tissues by binding to thenuclear vitamin D receptor. Alternatively, 1,25(OH)2 D3 can bind to theplasma membrane VDR and induce non-genomic actions, in particular,stimulation of intestinal calcium transport.Vitamin D is a steroid substance that is essential for all vertebratesto maintain calcium and phosphorus metabolism within optimal limits, ahealthy skeleton, muscle contraction, modulation of cell growth and neuromuscular function. Calciferol also regulates the immune system, inhibits the development of pathological cells, angiogenesis and inflammatoryreactions. The active form of vitamin D, 1,25(OH)2 D3, stimulates intestinal absorption and renal Ca reabsorption and maintains its minimumphysiological level in the blood.Vitamin D deficiency in goats leads to a decrease in productivity, causesa decrease in intestinal and renal calcium reabsorption, which leads to theincrease in parathyroid hormone levels. This process leads to activation ofosteocytes and, as a result, accelerates bone demineralisation, causing thedevelopment of many diseases in adults, including nutritional and fibrousosteodystrophy, secondary osteodystrophy, endocrine dysfunction), as wellas rickets in young animals. The development of non-skeletal pathologies,in particular, inflammatory, neoplastic and autoimmune diseases, is also associated with cholecalciferol deficiency in the body. In addition, disordersof D-vitamin and calcium-phosphorus metabolism in goats cause the development of postpartum hypocalcaemia and postpartum hypophosphatemia.In the animal body, calcium and phosphorus homeostasis is maintained by a coordinated interaction of absorption and reabsorptionthrough the gastrointestinal tract and kidneys, as well as by storage and mobilization from bone tissue and is regulated mainly by biologically active cholecalciferol metabolites - 25OH D3, 1,25(OH)2 D3, as wellas parathyroid hormone (PTH; synthesised by the pineal glands) andcalcitonin (CT; produced by sparafollicular (light) thyroid C cells) andfibroblast growth factor-23 (FGF23).In contrast to monogastric animals, small ruminants do not modulaterenal calcium excretion in response to calcium limitation in the diet. Themobilization of Ca and P from the skeleton is stimulated by PTH throughosteoclast activation mediated by receptor activator of nuclear factor-κB(RANK). Vitamin D maintains Ca (by stimulating CaZB) and P homeostasis (the direct rapid action of 1,25(OH)2 D3 has been proven to have a directeffect on the absorption of these vital elements in the intestine, reabsorptionof these cations in the renal tubules and their mobilization from bone tissue).Phosphorus is a component of adenosine triphosphate (ATP) and nucleotides. Macroergic phosphate compounds, among which the main oneis adenosine triphosphate acid, provide both the accumulation of energyreserves and its consumption (ATP, ADP, creatine phosphate), affectingprotein, lipid, carbohydrate, mineral, and energy metabolism. An interaction between vitamin D and fibroblast growth factor 23 (FGF23), a bonehormone that causes the development of phosphaturia and reduces thesynthesis of 1,25(OH)2 D3, has been identified.Despite the multidirectionality of etiological factors, common to allforms of osteodystrophy is a disruption of the processes of bone formation and renewal, which is manifested by increased mobilization of calcium, phosphorus and other elements from bone tissue, so the pathologyis accompanied by osteomalacia, osteoporosis and osteofibrosis, and aviolation of the mechanism of maintaining their homeostasis.The main factors of osteodystrophy in animals are feeding disordersand physical inactivity, and the leading links in its pathogenesis are theimbalance between bone formation and resorption.The main methods for diagnosing disorders of D-vitamin and calcium-phosphorus metabolism in goats are clinical, physical, biochemical,enzyme-linked immunosorbent assays and pathological and morphological studies. Biochemical analysis in goat serum determines the content oftotal calcium, inorganic phosphorus, activity of alkaline phosphatase andits isozymes, and immunoassay the concentration of 25OH D3, 1,25(OH)2D3, calcitonin and parathyroid hormone. Keywords: goats, vitamin D, metabolites, metabolism, calcium,phosphorus, liver, kidneys.

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Assessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

Cited by 3 publications

References 45 publications

Is There an Association Between Inflammation and Serum-Vitamin D? – Results of a Retrospective Analysis of Hospitalized Geriatric Patients

Is There an Association Between Inflammation and Serum-Vitamin D? – Results of a Retrospective Analysis of Hospitalized Geriatric Patients

A Practical Guide to Adjust Micronutrient Biomarkers for Inflammation Using the BRINDA Method

Metabolism of vitamin D, Calcium and Phosphorus and their disorders in goats

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