Assessment of Ventricular Function in Adults with Sickle Cell Disease: Role of Two-Dimensional Speckle-Tracking Strain

Ventricular global longitudinal strain is altered in children with sickle cell disease

“…This is the largest of only 8 studies to evaluate GLS in SCD and the third to evaluate it in children (Almeida et al , ; Ahmad et al , ; Blanc et al , ; Sengupta et al , ; Barbosa et al , ; Hammoudi et al , ; Braga et al , ; Tolba et al , ). In the two other paediatric studies to date, RVGLS was reported to be decreased in children compared with controls, but differences in evaluation technique or patient population may account for these discrepancies (Blanc et al , ; Tolba et al , ).…”

“…The increase in RVGLS did not associate with the number of lifetime vaso-occlusive events experienced, demonstrating that cardiac abnormalities may occur in the absence of classical markers of disease severity. This is the largest of only 8 studies to evaluate GLS in SCD and the third to evaluate it in children (Almeida et al, 2008;Ahmad et al, 2012;Blanc et al, 2012;Sengupta et al, 2012;Barbosa et al, 2014;Hammoudi et al, 2014;Braga et al, 2015;Tolba et al, 2017). In the two other paediatric studies to date, RVGLS was reported to be decreased in children compared with controls, but differences in evaluation technique or patient population may account for these discrepancies (Blanc et al, 2012;Tolba et al, 2017).…”

Added value of speckle tracking in the evaluation of cardiac function in patients with sickle cell disease

“…Compared to the LVEF, the LV‐GLS is less affected by changes in loading conditions, which makes it a potentially useful tool in patients with sickle cell disease (SCD), due to the chronic overload associated with SCD. However, in this population, studies are rare and results are conflicting (Ahmad et al , ; Sengupta et al , ; Barbosa et al , ; Hammoudi et al , ).…”

Altered Left Ventricular Twist Is Associated with Clinical Severity in Adults and Adolescents with Homozygous Sickle Cell Anemia

“…However, global RV longitudinal strain was still within the normal range in the individuals with SCD. Barbosa et al, 35 in a recent published study in which 90 adult patients with SCD underwent two-dimensional strain assessment, showed no difference in LV and RV systolic function compared with healthy controls. Rotational measures derived from speckletracking were not applied.…”