Assessment of vascular remodeling under antiangiogenic therapy using DCE‐MRI and vessel size imaging

Zwick, Stefan; Strecker, Ralph; Kiselev, Valerij G.; Gall, Peter; Huppert, Jochen; Palmowski, Moritz; Lederle, Wiltrud; Woenne, Eva C.; Hengerer, Arne; Taupitz, Matthias; Semmler, Willi; Kießling, Fabian

doi:10.1002/jmri.21710

Cited by 62 publications

(62 citation statements)

References 29 publications

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“…Several recent studies have reported that vessel size imaging can successfully characterize cerebral tumor vascularization with elevated MVD and relatively stable VSI (Kiselev et al, 2005;Ungersma et al, 2010;Valable et al, 2008;Zwick et al, 2009). This novel technique has recently been applied to animal ischemic stroke models (Bosomtwi et al, 2008;Lin et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Vessel Size Imaging Reveals Pathological Changes of Microvessel Density and Size in Acute Ischemia

Schmidt

Villringer

et al. 2011

J Cereb Blood Flow Metab

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The aim of this study was to test the feasibility of vessel size imaging with precise evaluation of apparent diffusion coefficient and cerebral blood volume and to apply this novel technique in acute stroke patients within a pilot group to observe the microvascular responses in acute ischemic tissue. Microvessel density-related quantity Q and mean vessel size index (VSI) were assessed in 9 healthy volunteers and 13 acute stroke patients with vessel occlusion within 6 hours after symptom onset. Our results in healthy volunteers matched with general anatomical observations. Given the limitation of a small patient cohort, the median VSI in the ischemic area was higher than that in the mirrored region in the contralateral hemisphere (P < 0.05). Decreased Q was observed in the ischemic region in 2 patients, whereas no obvious changes of Q were found in the remaining 11 patients. In a patient without recanalization, the VSI hyperintensity in the subcortical area matched well with the final infarct. These data reveal that different observations of microvascular response in the acute ischemic tissue seem to emerge and vessel size imaging may provide useful information for the definition of ischemic penumbra and have an impact on future therapeutic approaches.

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Section: Introductionmentioning

confidence: 99%

Vessel Size Imaging Reveals Pathological Changes of Microvessel Density and Size in Acute Ischemia

Schmidt

Villringer

et al. 2011

J Cereb Blood Flow Metab

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“…For noninvasive assessment of angiogenesis, magnetic resonance imaging (MRI) techniques such as dynamic contrast-enhanced MRI (DCE-MRI) and vessel size imaging (VSI) can be applied to assess vascular changes such as vessel remodeling by the calculation of quantitative biomarkers (13,14). DCE-MRI is widely used in preclinical cancer research as well as in oncologic patients, including applications in bone metastases, whereas VSI is a comparatively new technique (15,16).…”

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confidence: 99%

Drug-Induced Vessel Remodeling in Bone Metastases as Assessed by Dynamic Contrast Enhanced Magnetic Resonance Imaging and Vessel Size Imaging: A LongitudinalIn vivoStudy

Bäuerle

Merz

Komljenovic

et al. 2010

Clinical Cancer Research

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Purpose: The aim of this study was to assess the antiangiogenic treatment effects of zoledronic acid (ZA) and sunitinib malate (SM) noninvasively in experimental breast cancer bone metastases by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and vessel size imaging.Experimental Design: Nude rats bearing bone metastases after inoculation of MDA-MB-231 breast cancer cells were treated with ZA (40 μg/kg weekly; n = 8 rats), SM (20 mg/kg daily; n = 8 rats), or their combination (ZA and SM; n = 8 rats) and compared with sham-treated controls (n = 10 rats). Vascular changes in bone metastases were longitudinally imaged in vivo using DCE-MRI [amplitude (A) and exchange rate coefficient (k ep )] and vessel size imaging [blood volume (BV) and vessel size index (VI)]. In addition, antiresorptive and antitumor changes were assessed in these lesions by flat-panel volumetric computed tomography as well as morphologic MRI and diffusion-weighted imaging.Results: In bone metastases, significant changes in A, k ep , BV, and VI in accordance with decreased blood volume and vessel permeability as well as with increased mean vessel diameters were observed after application of ZA and SM as compared with controls. In this longitudinal study, antiangiogenic changes preceded the inhibition of osteolysis and antitumor effects after treatment.Conclusions: These results indicate vessel remodeling in breast cancer bone metastases on ZA and SM treatment and implicate substantial effects on imaging and treatment of malignant bone lesions. Clin Cancer Res; 16(12); 3215-25. ©2010 AACR.

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“…Due to the interest in studying vasculature and its morphologic changes resulting from various pathologies and treatments, these vascular imaging techniques have been explored in a variety of anatomies and pathologies, including brain tumor vasculature in mice (21,22) and rats (23,24), the vasculature of xenograft tumors in mice (25), and vascularization of human brain tumors using a gadoliniumbased contrast agent rather than a USPIO agent (26). The USPIO vessel imaging technique has also been used for detecting changes in blood volume and VSI due to antiangiogenic treatment (27,28).…”

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Vessel imaging with viable tumor analysis for quantification of tumor angiogenesis

Pacheco²,

et al. 2011

Magnetic Resonance in Med

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*Imaging of tumor microvasculature has become an important tool for studying angiogenesis and monitoring antiangiogenic therapies. Ultrasmall paramagnetic iron oxide contrast agents for indirect imaging of vasculature offer a method for quantitative measurements of vascular biomarkers such as vessel size index, blood volume, and vessel density (Q). Here, this technique is validated with direct comparisons to ex vivo micro-computed tomography angiography and histologic vessel measurements, showing significant correlations between in vivo vascular MRI measurements and ex vivo structural vessel measurements. The sensitivity of the MRI vascular parameters is also demonstrated, in combination with a multispectral analysis technique for segmenting tumor tissue to restrict the analysis to viable tumor tissue and exclude regions of necrosis. It is shown that this viable tumor segmentation increases sensitivity for detection of significant effects on blood volume and Q by two antiangiogenic therapeutics [anti-vascular endothelial growth factor (anti-VEGF) and anti-neuropilin-1] on an HM7 colorectal tumor model. Anti-vascular endothelial growth factor reduced blood volume by 36 6 3% (p < 0.0001) and Q by 52 6 3% (p < 0.0001) at 48 h post-treatment; the effects of anti-neuropilin-1 were roughly half as strong with a reduction in blood volume of 18 6 6% (p < 0.05) and a reduction in Q of 33 6 5% (p < 0.05) at 48 h post-treatment. Magn Reson Med 63:1637-1647,

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Assessment of vascular remodeling under antiangiogenic therapy using DCE‐MRI and vessel size imaging

Cited by 62 publications

References 29 publications

Vessel Size Imaging Reveals Pathological Changes of Microvessel Density and Size in Acute Ischemia

Vessel Size Imaging Reveals Pathological Changes of Microvessel Density and Size in Acute Ischemia

Drug-Induced Vessel Remodeling in Bone Metastases as Assessed by Dynamic Contrast Enhanced Magnetic Resonance Imaging and Vessel Size Imaging: A LongitudinalIn vivoStudy

Vessel imaging with viable tumor analysis for quantification of tumor angiogenesis

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