Assessment of Vascular Patency and Inflammation with Intravascular Optical Coherence Tomography in Patients with Superficial Femoral Artery Disease Treated with Zilver PTX Stents

Hoyt, Taylor; Feldman, Marc D.; Okutucu, Sercan; Lendel, Vasili; Marmagkiolis, Konstantinos; McIntosh, Victoria J.; Ateş, İsmail; Kose, Gulcan; Mego, David M.; Paixao, Andre; Iliescu, Cezar; Park, Jongwan; Shaar, Mohammad; Avci, Recep; McElroy, Austin; Dijkstra, Jouke; Milner, Thomas E.; Çilingiroğlu, Mehmet

doi:10.1016/j.carrev.2019.07.009

Cited by 1 publication

(1 citation statement)

References 46 publications

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“…In the S. aureus-infected group, a large number of PGRP and PTX-3 proteins were expressed in the vicinity of the acini. PGRP 24 and PTX-3 25 proteins are closely related to inflammation. The expression of PGRP and PTX-3 in the melatonin + S. aureus group was significantly lower than that in the S. aureus group (Figure 1N,O).…”

Section: Effects Of Melatonin On Pathology Induced By S Aureus In Vit...mentioning

confidence: 99%

Melatonin Maintains Homeostasis and Potentiates the Anti-inflammatory Response in Staphylococcus aureus-Induced Mastitis through microRNA-16b/YAP1

Chen

Wang

Guo

et al. 2022

J. Agric. Food Chem.

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Staphylococcus aureus is a highly infectious pathogen and is a considerable threat to food hygiene and safety. Although melatonin is thought to exert an ameliorative effect on bovine mastitis, the regulatory mechanisms are unclear. In this study, we first verified the therapeutic effect of melatonin against S. aureus in vitro and in vivo, a screening of differentially expressed miRNAs and mRNAs among the blank, and S. aureus and melatonin + S. aureus groups by high-throughput sequencing identified miR-16b and YAP1, which exhibited 1.95-fold upregulated and 1.05-fold downregulated expression, respectively. Moreover, epigenetic studies showed that S. aureus inhibited miR-16b expression by methylation (increased DNMT1 expression). Additionally, the DNMT1 expression level was significantly decreased by melatonin treatment, which might indicate that the inhibition of DNMT1 by melatonin reduces the effect of S. aureus on miR-16b. The flow cytometry, scanning and transmission electron microscopy, EdU assay, and cell morphology results indicated that miR-16b in bovine mammary epithelial cells (in vitro) and in mice (in vivo) can modulate the maintenance of homeostasis and potentiate the anti-inflammatory response. In addition, YAP1 was demonstrated to be the target gene of miR-16b through quantitative real-time polymerase chain reaction, western blot, RNA immunoprecipitation, and functional assays. This study indicates that melatonin inhibits S. aureus-induced inflammation via microRNA-16b/YAP1-mediated regulation, and these findings might provide a new strategy for the prevention of bovine mastitis, facilitating further studies good of zoonotic diseases caused by S. aureus infection.

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Section: Effects Of Melatonin On Pathology Induced By S Aureus In Vit...mentioning

confidence: 99%

Melatonin Maintains Homeostasis and Potentiates the Anti-inflammatory Response in Staphylococcus aureus-Induced Mastitis through microRNA-16b/YAP1

Chen

Wang

Guo

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

Assessment of Vascular Patency and Inflammation with Intravascular Optical Coherence Tomography in Patients with Superficial Femoral Artery Disease Treated with Zilver PTX Stents

Cited by 1 publication

References 46 publications

Melatonin Maintains Homeostasis and Potentiates the Anti-inflammatory Response in Staphylococcus aureus-Induced Mastitis through microRNA-16b/YAP1

Melatonin Maintains Homeostasis and Potentiates the Anti-inflammatory Response in Staphylococcus aureus-Induced Mastitis through microRNA-16b/YAP1

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