Assessment of variability of renal blood flow Doppler parameters during the menstrual cycle in women

Krejza, Jarosław; Ustymowicz, Andrzej; Szylak, A.; Tomaszewski, Michał; Hryniewicz, Andrzej; Jawad, Abbas F.

doi:10.1002/uog.1771

Cited by 9 publications

(4 citation statements)

References 39 publications

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“…However, we did not find any correlation between PI, menstrual cycle and sex hormones. In line with this finding, a study examining renal Doppler flow parameters in females between the follicular and the luteal phases of the menstrual cycle did not find differences in RRI, suggesting no impact of sex-related hormonal alterations on renal vascular properties [ 26 ]. However, RRI is also influenced by other systemic factors such as HR, BP and arterial stiffness [ 27 ].…”

Section: Discussionmentioning

confidence: 72%

Determinants of Renal Micro-Perfusion as Assessed with Contrast-Enhanced Ultrasound in Healthy Males and Females

Trillig

Damianaki

Hendriks-Balk

et al. 2023

JCM

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(1) Background: The renal microcirculation is essential to maintain the renal function, but its determinants in humans have been poorly studied. Contrast-enhanced ultrasound (CEUS) allows the non-invasive quantification of the cortical micro-perfusion at the bedside using the perfusion index (PI). The aims of this study were to assess whether differences exist in PI between healthy males and females and to identify clinical determinants associated with cortical micro-perfusion. (2) Methods: Healthy, normotensive volunteers (eGFR > 60 mL/min/1.73 m2, no albuminuria) underwent CEUS under standardized conditions with the destruction–reperfusion (DR) technique. The mean PI of four DR sequences was reported as the primary outcome measure (3) Results: A total of 115 subjects (77 females and 38 males) completed the study; the mean ± SD age was, respectively, 37.1 ± 12.2 and 37.1 ± 12.7 years in females and males, and the mean eGFR was 105.9 ± 15.1 and 91.0 ± 17.4 mL/min/1.73 m2. The PI (median) was higher in females than in males, i.e., 2705 (IQR 1641–3777) vs. 1965 (IQR 1294–3346) arbitrary units (a.u), p = 0.02). A correlation analysis showed positive associations between PI and eGFR, female sex, heart rate, plasma renin activity (PRA) and plasma aldosterone concentrations (PAC), negative associations with potassium, bicarbonate and systolic blood pressure, and no associations with age, body mass index and renal resistive index (RRI). In a multivariate linear regression analysis, only PRA remained significantly associated with PI. (4) Conclusions: Although the PI was higher among females, this association was no longer significant after adjustment for covariates. There was no difference in females tested during the follicular or the luteal phases. In conclusion, the PI was only weakly influenced by classic clinical variables, but was positively associated with PRA, suggesting that the renin–angiotensin system plays a role in the regulation of the cortical micro-perfusion in humans. Identifying which other factors contribute to the large variations in micro-perfusion across individuals needs further study.

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Section: Discussionmentioning

confidence: 72%

Determinants of Renal Micro-Perfusion as Assessed with Contrast-Enhanced Ultrasound in Healthy Males and Females

Trillig

Damianaki

Hendriks-Balk

et al. 2023

JCM

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“…Third, the present study dealt with males and females without distinguishing between sexes. Differences in haemodynamics might be present in females depending on the menstrual cycle (Krejza et al, 2005; Asbeutah et al, 2014). Fourth, comparisons with actual changes in plasma renin activity depending on the presence or absence of rest before sonographic examination were not investigated.…”

Section: Discussionmentioning

confidence: 99%

Influence of resting before sonographic examination on Doppler measurements of renal blood flow

Shibasaki

Kishino

Fujiwara

et al. 2020

Clin Physio Funct Imaging

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Renal artery stenosis (RAS) is the most common cause of secondary hypertension, via increases in plasma renin–angiotensin–aldosterone levels. Renal artery stenosis is diagnosed from blood examinations such as renin activity and from imaging examinations such as sonography. Patients are required to lie on the bed for 30 min before and during phlebotomy, since plasma renin activity is easily altered by posture. However, no such pre‐examination rest is required for sonography. The present study therefore investigated the possible influence of resting before examination on Doppler parameters used for the diagnosis of RAS. Subjects comprised 55 healthy young adults (24 males, 31 females; mean age, 22 ± 1 years). Sonographic measurements were made shortly after subjects entered the examination room and again after 30 min of rest lying on a bed. Median peak systolic velocity in the renal artery was significantly decreased after rest (106 cm/s, interquartile range (IQR) 96–121 cm/s) compared with before rest (120 cm/s, IQR 107–135 cm/s; p < .001). Median acceleration time in the intra‐renal segmental artery was also significantly shorter after rest (49 ms, IQR 38–54 ms) compared to before rest (50 ms, IQR 38–59 ms; p = .039). The present results suggest that serious consideration should be given regarding whether pre‐examination resting is needed to accurately interpret Doppler measurements of renal blood flow when diagnosing RAS from sonography.

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“…1). The peak-systolic, end-diastolic, and mean velocities were measured in 3 beats and the average values were used for analysis [8].…”

Section: Color Doppler Ultrasoundmentioning

confidence: 99%

Effects of intravenous bolus injection of nicorandil on renal artery flow velocity assessed by color Doppler ultrasound

Shimamoto

Kubo

Tanabe

et al. 2017

Journal of Cardiology

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Assessment of variability of renal blood flow Doppler parameters during the menstrual cycle in women

Abstract: Objective

Cited by 9 publications

References 39 publications

Determinants of Renal Micro-Perfusion as Assessed with Contrast-Enhanced Ultrasound in Healthy Males and Females

Determinants of Renal Micro-Perfusion as Assessed with Contrast-Enhanced Ultrasound in Healthy Males and Females

Influence of resting before sonographic examination on Doppler measurements of renal blood flow

Effects of intravenous bolus injection of nicorandil on renal artery flow velocity assessed by color Doppler ultrasound

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