Assessment of Tumor Stiffness With Shear Wave Elastography in a Human Prostate Cancer Xenograft Implantation Model

Wang, Yiru; Yao, Binwei; Li, Hongfei; Zhang, Yan; Gao, Hanjing; Gao, Yabin; Peng, Ruiyun; Tang, Jie

doi:10.7863/ultra.16.03066

Cited by 29 publications

(25 citation statements)

References 43 publications

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“…9,10 Shear wave elastography (SWE) is another diagnostic technique that can assess prostate stiffness, which is higher in PCa than benign tissue. [11][12][13][14] However, we did not find a published report comparing multiparametric TRUS, including grayscale imaging, color Doppler imaging, CEUS, and SWE, with multiparametric MRI in the diagnosis of PCa during our literature review.…”

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confidence: 81%

Diagnostic Performance of Multiparametric Transrectal Ultrasound in Localized Prostate Cancer: A Comparative Study With Magnetic Resonance Imaging

Zhang

Tang

Luo

et al. 2018

J of Ultrasound Medicine

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Objectives-The aim of this study was to compare the diagnostic performance of multiparametric transrectal ultrasound (TRUS), including grayscale imaging, color Doppler imaging, shear wave elastography, and contrast-enhanced ultrasound, to that of multiparametric magnetic resonance imaging (MRI), including T2-weighted, diffusion-weighted, and dynamic contrast-enhanced MRI, in the diagnosis of localized prostate cancer (PCa; lesions at stage T2 or lower).Methods-Seventy-eight patients were prospectively enrolled, including 40 in a benign prostate group and 38 in a localized PCa group (≤T2). The diagnostic performance of multiparametric TRUS and multiparametric MRI in detecting localized PCa was analyzed with surgical and biopsy pathologic results as the references.Results-Multiparametric TRUS had higher sensitivity, negative predictive value, and accuracy than multiparametric MRI (97.4% versus 94.7%, 96.9% versus 92.3%, and 87.2% versus 76.9%, respectively) for detecting localized PCa. The mean area under the receiver operating characteristic curve AE SD for multiparametric TRUS was 0.874 AE 0.043 (95% confidence interval, 0.790-0.959), and it was 0.774 AE 0.055 (95% confidence interval, 0.666-0.881) for multiparametric MRI.Conclusions-Our results suggest that multiparametric TRUS has high diagnostic performance in the diagnosis of localized PCa. Multiparametric TRUS is compatible with multiparametric MRI in the detection of localized PCa (≤T2).

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confidence: 81%

Diagnostic Performance of Multiparametric Transrectal Ultrasound in Localized Prostate Cancer: A Comparative Study With Magnetic Resonance Imaging

Zhang

Tang

Luo

et al. 2018

J of Ultrasound Medicine

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“…Then the sections were immersed in Sirius Red solution (0.1% Sirius Red in saturated picric acid, pH 2.0) for 1 h, rinsed briefly in 0.01 M HCl solution and then in water for 1 min, counterstained with hematoxylin for 1 min, differentiated in acid alcohol solution, rehydrated and mounted. Slides were visualized under polarized light microscopy, and photomicrographs were taken with identical exposure settings for all sections, as previous described (Meruane et al, 2012 ; Wang et al, 2017 ).…”

Section: Methodsmentioning

confidence: 99%

The Superficial Dermis May Initiate Keloid Formation: Histological Analysis of the Keloid Dermis at Different Depths

et al. 2017

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Several studies have reported on certain aspects of the characteristics of different sites within a keloid lesion, but detailed studies on the keloid dermis at different depths within a keloid lesion are scarce. The aim of this study was to investigate the histology of the keloid dermis at different depths. This study included 19 keloid tissue samples that were collected from 19 patients and 19 normal skin samples, which were harvested from subjects without keloids or hypertrophic scar. Samples were studied by light microscopy using routine hematoxylin and eosin histochemical staining, and immunohistochemistry to detect CD20-positive B-lymphocytes and CD3-positive T-lymphocytes. Sirius Red histochemical staining was used to determine the type of collagen in keloid tissue and normal skin samples. The migratory properties of fibroblasts within the keloid dermis at different depths was compared, using an in vitro migration assay. The findings of this study showed that although the papillary and reticular dermis could be clearly distinguished in normal skin, three tissue layers were identified in the keloid dermis. The superficial dermis of keloid was characterized by active fibroblasts and lymphocytes; the middle dermis contained dense extracellular matrix (ECM) with large numbers fibroblasts, and the deep dermis was poorly cellular and characterized by hyalinized collagen bundles. In the keloid samples, from the superficial to the deep dermis, type I collagen increased and type III collagen decreased, and fibroblasts from the superficial dermis of the keloid were found to migrate more rapidly. In conclusion, the findings of this study showed that different depths within the keloid dermis displayed different biological features. The superficial dermis may initiate keloid formation, in which layer intralesional injection of pharmaceuticals and other treatments should be performed for keloid.

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“…41,42 Similarly, technologies such as elastography are helping clinicians visualize changes in prostate stiffness related to cancer. 43,44 While these technologies have created important advancements in understanding diseases of relatively homogeneous tissues (eye, prostate), heterogeneous tissues pose a significant challenge in determining stiffness related to pathology, disease or injury. The spine is such an example where changes in its stiffness may reflect specific conditions.…”

Section: Clinical Advances As a Results Of Assistive Technologiesmentioning

confidence: 99%

Clinicians’ Ability to Detect a Palpable Difference in Spinal Stiffness Compared With a Mechanical Device

Kawchuk

Miazga

Pagé

et al. 2019

Journal of Manipulative and Physiological Therapeutics

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Objective: To determine if the physiological limits of human palpation influence traditional examination procedures. Methods: In this study, the threshold at which a change in spinal stiffness was detected was quantified in 12 experienced clinicians by changing the differential stiffness in two inflatable targets until the clinician could no longer identify which was stiffer. In the second part of the study, clinicians were then asked to palpate pre-identified pairs of vertebrae in an asymptomatic volunteer and to identify the stiffer of the pair (T7&L3, T7&L4, L3&L4) while the biomechanical stiffness of each vertebral pair was quantified objectively by a validated instrument. Results: The mean stiffness detection threshold for the clinicians was 8%. Objective measurement of the stiffness differential between vertebral pairs was 30% for T7* & L3 and 20% for T7* & L4 and 10% for L3* & L4 (*denotes the stiffer of the pair). Ten of 12 clinicians correctly identified T7 as more stiff when compared to L3 and T7 as more stiff than L4. Alternatively, when the differential vertebral pair stiffness was similar to the stiffness detection threshold (~8%), clinicians were less successful in identifying the stiffer vertebra of the pair; 4/12 clinicians correctly identified L3 as being more stiff compared to L4. Conclusion: These results suggest that the physiological limits of human palpation may limit the ability of clinicians to identify small alterations in spine stiffness.

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Assessment of Tumor Stiffness With Shear Wave Elastography in a Human Prostate Cancer Xenograft Implantation Model

Abstract: Shear wave elastography is a novel useful technology for showing the elasticity of human prostate cancer xenograft implantation tumors. Collagen fibers, especially collagen type I, play a crucial role in the elasticity in the human prostate cancer xenograft implantation model.

Cited by 29 publications

References 43 publications

Diagnostic Performance of Multiparametric Transrectal Ultrasound in Localized Prostate Cancer: A Comparative Study With Magnetic Resonance Imaging

Diagnostic Performance of Multiparametric Transrectal Ultrasound in Localized Prostate Cancer: A Comparative Study With Magnetic Resonance Imaging

The Superficial Dermis May Initiate Keloid Formation: Histological Analysis of the Keloid Dermis at Different Depths

Clinicians’ Ability to Detect a Palpable Difference in Spinal Stiffness Compared With a Mechanical Device

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