Assessment of tumor hypoxia by 62Cu-ATSM PET/CT as a predictor of response in head and neck cancer: a pilot study

Abstract

The results of this pilot study suggested that (62)Cu-ATSM uptake may be a predictive indicator of tumor response to chemoradiotherapy in patients with locally advanced head and neck cancer.

Positron emission tomography to assess hypoxia and perfusion in lung cancer

“…The short-lived radionuclides can be used for sequential measurements, whereas radionuclides with longer half lives do Table 2 for full names. Lewis et al [133] , Yuan et al [134] , Kersemans et al [135] , Matsumoto et al [136] Ballegeer et al [137] , Bowen et al [138] , Lewis et al [133] , Myerson et al [139] , O'Donoghue et al [72] Ballegeer et al [137] , Hansen et al [140] , Matsumoto et al [136] , McCall et al [66] , O'Donoghue et al [72] , Oh et al [74] , Yuan et al [134] Grigsby et al [141] , Tateishi et al [142] , Valtorta et al [143] , Weeks et al [144] Dence et al [145] , Kersemans et al [135] , Lewis et al [146] , Matsumoto et al [136] , O'Donoghue et al [72] Dehdashti et al [86] , Lohith et al [67] , Wong et al [80] , Zhang et al [81] Chao et al [147] , Dehdashti et al [148] , Dehdashti et al [149] , Dietz et al [150] , Grassi et al [151] , Grigsby et al [141] , Kositwattanarerk et al [152] , Laforest et al [153] , Lewis et al [154] , Minagawa et al [155] , Nyflot et al [156] [ Mahy et al [158] , Mahy et al …”

62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET in Human Gliomas: Comparative Study with [18F]Fluorodeoxyglucose and L-Methyl-[11C]Methionine PET

“…22 In line with these observations, several clinical studies on lung and cervical cancers have directly compared 62 Cu-ATSM-PET with FDG-PET and suggested that intratumoral distribution and uptake values may be different, depending on the histopathologic type of the tumor. 15,23 In addition, a previous study using a lung Cu-ATSM (T/B cutoff threshold Ն1.8), FDG (T/B cutoff threshold of Ն1.5), and MET (T/B cutoff threshold of Ն1.3). P values Ͻ .05 were considered to indicate statistical significance.…”

PET Imaging in Head and Neck Cancer Patients to Monitor Treatment Response: A Future Role for EGFR-Targeted Imaging

“…Pretreatment Cu-labeled (diacetyl-bis(N4-methylthiosemicarbazone)) ( 62 Cu-ATSM), for quantifying hypoxia, which was shown to have prognostic value for response to chemoradiotherapy, could be predicted by high pretreatment SUV max (>5.0; ref. 19). This was supported by results from another recent study in which high pretreatment 62 Cu-ATSM tumor uptake correlated with a reduced PFS (20).…”