Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 Tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo

Krug, Roland; Carballido‐Gamio, Julio; Burghardt, Andrew J.; Kazakia, Galateia J.; Hyun, Benedict; Jobke, Björn; Banerjee, Suchandrima; Huber, Markus; Link, Thomas M.; Majumdar, Sharmila

doi:10.1007/s00198-007-0495-9

Cited by 70 publications

(85 citation statements)

References 27 publications

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“…First, partial volume effects, produced when imaging trabeculae that are smaller than the spatial resolution, may confound and overestimate measures of bone microarchitecture such as BVTV and Tb.Th (9,20). However, studies have demonstrated that "apparent" histomorphometric measures derived from MRI correlate well with measures derived through the use of higher-resolution modalities, such as micro-computed tomography, wherein partial volume effects are mitigated (21). Second, the 195 m in-plane resolution limited our ability to resolve cortical bone, which is more porous in individuals with type 2 DM (47).…”

Section: Pritchard Et Almentioning

confidence: 99%

“…It has been argued, however, that the resolution of MRIs limits the accurate assessment of such 2-D variables because the images are acquired at the current limits of clinical spatial resolution and can be confounded by partial volume effects (20). However, MRI-based assessment of microarchitecture has proven to be promising because these "apparent" 2-D measures derived using MRI correlate well with measures derived by direct histomorphometry and higher resolution imaging (9,14,21).…”

Section: Introductionmentioning

confidence: 99%

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Association of larger holes in the trabecular bone at the distal radius in postmenopausal women with type 2 diabetes mellitus compared to controls

Pritchard¹,

Giangregorio²,

Atkinson³

et al. 2011

Arthritis Care & Research

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Objective. Adults with type 2 diabetes mellitus (DM) have an elevated fracture risk despite normal areal bone mineral density (aBMD). The study objective was to compare trabecular bone microarchitecture of postmenopausal women with type 2 DM and women without type 2 DM.Methods. An extremity 1T magnetic resonance imaging system was used to acquire axial images (195 ؋ 195 ؋ 1,000 m 3 voxel size) of the distal radius of women recruited from outpatient clinics or by community advertisement. Image segmentation yielded geometric, topologic, and stereologic outcomes, i.e., number and size of trabecular bone network holes (marrow spaces), endosteal area, trabecular bone volume fraction, nodal and branch density, and apparent trabecular thickness, separation, and number. Lumbar spine (LS) and proximal femur BMD were measured with dual x-ray absorptiometry. Microarchitectural differences were assessed using linear regression and adjusted for percent body fat, ethnicity, timed up-and-go test, Charlson Index, and calcium and vitamin D intake; aBMD differences were adjusted for body mass index (BMI). Results. Women with type 2 DM (n ‫؍‬ 30, mean ؎ SD age 71.0 ؎ 4.8 years) had larger holes (؉13.3%; P ‫؍‬ 0.001) within the trabecular bone network than women without type 2 DM (n ‫؍‬ 30, mean ؎ SD age 70.7 ؎ 4.9 years). LS aBMD was greater in women with type 2 DM; however, after adjustment for BMI, LS aBMD did not differ between groups. Conclusion. In women with type 2 DM, the average hole size within the trabecular bone network at the distal radius is greater compared to controls. This may explain the elevated fracture risk in this population.

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Section: Pritchard Et Almentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of larger holes in the trabecular bone at the distal radius in postmenopausal women with type 2 diabetes mellitus compared to controls

Pritchard¹,

Giangregorio²,

Atkinson³

et al. 2011

Arthritis Care & Research

View full text Add to dashboard Cite

show abstract

“…High correlation has been found also for trabecular number and spacing by comparing 3.0 T MR and high resolution pQCT. Histomorphometry and other different structural analysis techniques applied to both modalities provide different absolute values but high correlation (r > 0.8) for all bone structure parameters [34] . Micro-MR units with special high-field-strength (7 T, 11 T or higher) are used in experimental settings to obtain highresolution MR images of small animals in vivo or bone specimens in vitro.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

“…MRderived structural dimensions are similar, but not identical, to histological or microcomputed tomography (CT) dimensions and a twodimensional rather than threedimensional approach is applied [34,35] . A magnetic susceptibility difference of about 3 ppm existing between bone and marrow leads to signal dampening at the bonemarrow interface and, as a result, an artificial overestimation of trabecular dimension occurs.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

“…High field strengths and improved coil technology have made it possible to achieve an inplane resolution of about 150 µm [33] . However, because of current signaltonoise con straints, minimal slice thickness is usually about 500 µm [34] . Although this resolution is larger than trabe cular thickness, trabecular spacing (8001000 µm) is still much larger than the size of a single MR voxel, so that trabecular parameters can be reasonably measured or estimated with MRI.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

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Fractal lacunarity of trabecular bone and magnetic resonance imaging: New perspectives for osteoporotic fracture risk assessment

Alimazighi¹

2015

WJO

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Osteoporosis represents one major health condition for our growing elderly population. It accounts for severe morbidity and increased mortality in postmenopausal women and it is becoming an emerging health concern even in aging men. Screening of the population at risk for bone degeneration and treatment assessment of osteoporotic patients to prevent bone fragility fractures represent useful tools to improve quality of life in the elderly and to lighten the related socio-economic impact. Bone mineral density (BMD) estimate by means of dualenergy X-ray absorptiometry is normally used in clinical practice for osteoporosis diagnosis. Nevertheless, BMD alone does not represent a good predictor of fracture risk. From a clinical point of view, bone microarchitecture seems to be an intriguing aspect to characterize bone alteration patterns in aging and pathology. The widening into clinical practice of medical imaging techniques and the impressive advances in information technologies together with enhanced capacity of power calculation have promoted proliferation of new methods to assess changes of trabecular bone architecture (TBA) during aging and osteoporosis. Magnetic resonance imaging (MRI) has recently arisen as a useful tool to measure bone structure in vivo . In particular, high-resolution MRI techniques have introduced new perspectives for TBA characterization by non-invasive non-ionizing methods. However, texture analysis methods have not found favor with clinicians as they produce quite a few parameters whose interpretation is difficult. The introduction in biomedical field of paradigms, such as theory of complexity, chaos, and fractals, suggests new approaches and provides innovative tools to develop computerized methods that, by producing a limited number of parameters sensitive to pathology onset and progression, would speed up their application into clinical practice. Complexity of living beings and fractality of several physio-anatomic structures suggest fractal analysis as a promising approach to quantify morphofunctional changes in both aging and pathology. In this particular context, fractal lacunarity seems to be the proper tool to characterize TBA texture as it is able to describe both discontinuity of bone network and sizes of bone marrow spaces, whose changes are an index of bone fracture risk. In this paper, an original method of MRI texture analysis, based on TBA fractal lacunarity is described and discussed in the light of new perspectives for early diagnosis of osteoporotic fractures.

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Evaluation of trabecular microarchitecture in nonosteoporotic postmenopausal women with and without fracture

Kijowski

Tuite

Kruger

et al. 2012

Journal of Bone and Mineral Research

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Purpose To compare microscopic magnetic resonance imaging (μMRI) parameters of trabecular micro-architecture between postmenopausal women with and without fracture who have normal or osteopenic bone mineral density (BMD) on dual-energy x-ray absorptiometry (DXA). Methods The study included 36 post-menopausal Caucasian women 50 years of age and older with normal or osteopenic BMD (T-scores better than −2.5 at the lumbar spine, proximal femur, and one-third radius on DXA). Eighteen women had a history of low-energy fracture, while 18 women had no history of fracture and served as an age, race, and ultra-distal radius BMD-matched control group. A three-dimensional fast large-angle spin-echo (FLASE) sequence with 137 μm × 137 μm × 400 μm resolution was performed through the non-dominant wrist of all 36 women using the same 1.5T scanner. The high resolution images were used to measure trabecular bone volume fraction, trabecular thickness, surface-to-curve ratio, and erosion index. Wilcoxon signed rank tests were used to compare differences in BMD and μMRI parameters between post-menopausal women with and without fracture. Results Post-menopausal women with fracture had significantly lower (p<0.05) trabecular bone volume fraction and surface-to-curve ratio and significantly higher (p<0.05) erosion index than post-menopausal women without fracture. There was no significant difference between post-menopausal women with and without fracture in trabecular thickness (p=0.80) and BMD of the spine (p=0.21), proximal femur (p=0.19), one-third radius (p=0.47), and ultra-distal radius (p=0.90). Conclusions Post-menopausal women with normal or osteopenic BMD who had a history of low energy fracture had significantly different (p<0.05) μMRI parameters than an age, race, and ultra-distal radius BMD-matched control group of postmenopausal women with no history of fracture. Our study suggests that μMRI can be used to identify individuals without a DXA-based diagnosis of osteoporosis who have impaired trabecular micro-architecture and thus a heretofore-unappreciated elevated fracture risk.

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Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 Tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo

Abstract: Both imaging modalities were found to perform equally well regarding trabecular bone measurements.

Cited by 70 publications

References 27 publications

Association of larger holes in the trabecular bone at the distal radius in postmenopausal women with type 2 diabetes mellitus compared to controls

Association of larger holes in the trabecular bone at the distal radius in postmenopausal women with type 2 diabetes mellitus compared to controls

Fractal lacunarity of trabecular bone and magnetic resonance imaging: New perspectives for osteoporotic fracture risk assessment

Evaluation of trabecular microarchitecture in nonosteoporotic postmenopausal women with and without fracture

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